LISP based simulation generators for modeling complex space processes

The development of a simulation assistant for modeling discrete event processes is presented. Included are an overview of the system, a description of the simulation generators, and a sample process generated using the simulation assistant

Cultural Aspects of Consultation-Liaison Psychiatry

Culture influences thoughts, emotions, and behaviors in individuals, groups, and communities, and thus it can have a significant impact on the illness behavior and the practice of health care. Increasingly culturally competent medical practice is the goal for patients of diverse ethnic or cultural background

Association between genetic variant on chromosome 12p13 and stroke survival and recurrence: a one year prospective study in Taiwan

<p>Abstract</p> <p>Background</p> <p>The association between ischemic stroke and 2 single nucleotide polymorphisms (SNPs) on chromosome 12p13, rs12425791 and rs11833579 appears inconsistent across different samples. These SNPs are close to the ninjurin2 gene which may alter the risk of stroke by affecting brain response to ischemic injury. The purpose of this study was to investigate the association between these two SNPs and ischemic stroke risk, as well as prognostic outcomes in a Taiwanese sample.</p> <p>Methods</p> <p>We examined the relations of these two SNPs to the odds of new-onset ischemic stroke, ischemic stroke subtypes, and to the one year risk of stroke-related death or recurrent stroke following initial stroke in a case-control study. A total of 765 consecutive patients who had first-ever ischemic stroke were compared to 977 stroke-free, age-matched controls. SNPs were genotyped by Taqman fluorescent allelic discrimination assay. The association between ischemic stroke and SNPs were analyzed by multivariate logistic regression. Cox proportional hazard model was used to assess the effect of individual SNPs on stroke-related mortality or recurrent stroke.</p> <p>Results</p> <p>There was no significant association between SNP rs12425791 and rs11833579 and ischemic stroke after multiple testing corrections. However, the marginal significant association was observed between SNP rs12425791 and large artery atherosclerosis under recessive model (OR, 2.30; 95%CI, 1.22-4.34; q-value = 0.062). Among the 765 ischemic stroke patients, 59 died or developed a recurrent stroke. After adjustment for age, sex, vascular risk factors and baseline stroke severity, Cox proportional hazard analysis indicated that the hazard ratios were 2.76 (95%CI, 1.34-5.68; q-value, 0.02) and 2.15 (95%CI, 1.15-4.02; q-value, 0.03) for individuals with homozygous variant allele of rs12425791 and rs11833579, respectively.</p> <p>Conclusions</p> <p>This is a precedent study that found genetic variants of rs12425791 and rs11833579 on chromosome 12p13 are independent predictors of stroke-related mortality or stroke recurrence in patients with incident ischemic stroke in Taiwan. Further study is needed to explore the details of the physiological function and the molecular mechanisms underlying the association of this genetic locus with ischemic stroke.</p

Molecular epidemiology and evolutionary genetics of Mycobacterium tuberculosis in Taipei

<p>Abstract</p> <p>Background</p> <p>The control of tuberculosis in densely populated cities is complicated by close human-to-human contacts and potential transmission of pathogens from multiple sources. We conducted a molecular epidemiologic analysis of 356 <it>Mycobacterium tuberculosis </it>(MTB) isolates from patients presenting pulmonary tuberculosis in metropolitan Taipei. Classical antibiogram studies and genetic characterization, using mycobacterial interspersed repetitive-unit-variable-number tandem-repeat (MIRU-VNTR) typing and spoligotyping, were applied after culture.</p> <p>Methods</p> <p>A total of 356 isolates were genotyped by standard spoligotyping and the strains were compared with in the international spoligotyping database (SpolDB4). All isolates were also categorized using the 15 loci MIRU-VNTR typing method and combin with <it>NTF </it>locus and RD deletion analyses.</p> <p>Results</p> <p>Of 356 isolates spoligotyped, 290 (81.4%) displayed known spoligotypes and 66 were not identified in the database. Major spoligotypes found were Beijing lineages (52.5%), followed by Haarlem lineages (13.5%) and EAI plus EAI-like lineages (11%). When MIRU-VNTR was employed, 140 patterns were identified, including 36 clusters by 252 isolates and 104 unique patterns, and the largest cluster comprised 95 isolates from the Beijing family. The combination of spoligotyping and MIRU-VNTR revealed that 236 (67%) of the 356 isolates were clustered in 43 genotypes. Strains of the Beijing family was more likely to be of modern strain and a higher percentage of multiple drug resistance than other families combined (P = 0.08). Patients infected with Beijing strains were younger than those with other strains (mean 58.7 vs. 64.2, p = 0.02). Moreover, 85.3% of infected persons younger than 25 years had Beijing modern strain, suggesting a possible recent spread in the young population by this family of TB strain in Taipei.</p> <p>Conclusion</p> <p>Our data on MTB genotype in Taipei suggest that MTB infection has not been optimally controlled. Control efforts should be reinforced in view of the high prevalence of the Beijing strain in young population and association with drug resistance.</p

Psicoterapia desde la transculturalidad y la migración

The nature of intercultural psychotherapy for patients of different ethnic-cultural background, including migrants or refugees, is elaborated on the subjects of: orientation to psychotherapy, communication in therapy, the art of using an interpreter, therapist-patient relationship, relevant understanding of the problems, and the goal of psychotherapy to be aimed for. The emphasis is laid for the need of culture-competent therapy for every patient but particular attention and effort is needed when the patients have wide cultural gap with the therapists, such as migrant or ethnic minority.La naturaleza de la psicoterapia para pacientes de diferente origen étnico y cultural, incluyendo inmigrantes y refugiados, se elabora a partir de: la orientación de la psicoterapia, la comunicación en la terapia, la utilización de un intérprete, la relación terapeuta-paciente, la comprensión de los problemas y el objetivo perseguido por la psicoterapia. El énfasis se pone en la necesidad de la terapia cultural competente para cada paciente pero se requiere particular atención y esfuerzo cuando existe una amplia distancia cultural con los terapeutas, tal como sucede con los inmigrantes o las minorías étnicas

Efficient robust speech recognition with empirical mode decomposition using an FPGA chip with dual core

The purpose of this paper is to accelate the computing speed of Empirical Mode Decomposition (EMD) based on multi-core embedded systems for robust speech recognition. A reconfigurable chip, Field Programmable Gate Array (FPGA), is used for the implementation of the designed system. This paper applies EMD to discompose some noised speech signals into several Intrinsic Mode Functions (IMFs). These IMFs will be combined to recover the original speech by multiplying their corresponding weights which were trained by Genetic Algorithms (GA). After applying Empirical Mode Decomposition (EMD), we obtain a cleaner speech for recognition. Due to the complexity of the computation of the EMD, a dual-core architecture of embedded system on FPGA is proposed to accelerate the computing speed of EMD for robust speech recognition. This will enhance the efficiency of embedded speech recognition system

Integrating Citizen Scientist Data into the Surveillance System for Avian Influenza Virus, Taiwan

The continuing circulation and reassortment with low-pathogenicity avian influenza Gs/Gd (goose/Guangdong/1996)-like avian influenza viruses (AIVs) has caused huge economic losses and raised public health concerns over the zoonotic potential. Virologic surveillance of wild birds has been suggested as part of a global AIV surveillance system. However, underreporting and biased selection of sampling sites has rendered gaining information about the transmission and evolution of highly pathogenic AIV problematic. We explored the use of the Citizen Scientist eBird database to elucidate the dynamic distribution of wild birds in Taiwan and their potential for AIV exchange with domestic poultry. Through the 2-stage analytical framework, we associated nonignorable risk with 10 species of wild birds with >100 significant positive results. We generated a risk map, which served as the guide for highly pathogenic AIV surveillance. Our methodologic blueprint has the potential to be incorporated into the global AIV surveillance system of wild birds