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A tale of one city: intra-institutional variations in migrating VLE platform
City University London committed in 2009 to make Moodle the Virtual Learning Environment (VLE) at the core of a new Strategic Learning Environment (SLE) comprised of VLE, externally facing website and related systems such as video streaming and virtual classrooms. Previously, the WebCT VLE had been separate from most of the other systems at the institution with very limited connections to other tools. Each of the schools within the institution was able to pursue their own strategy and timeframe for the migration and embedding of Moodle within their subject areas, within an absolute limit of 2 years. This paper outlines the approaches taken by the various schools, highlighting similarities and differences, and draws out common aspects from the project to make recommendations for institutions seeking to undertake similar migrations
Controlled DNA compaction within chromatin: the tail-bridging effect
We study the mechanism underlying the attraction between nucleosomes, the
fundamental packaging units of DNA inside the chromatin complex. We introduce a
simple model of the nucleosome, the eight-tail colloid, consisting of a charged
sphere with eight oppositely charged, flexible, grafted chains that represent
the terminal histone tails. We demonstrate that our complexes are attracted via
the formation of chain bridges and that this attraction can be tuned by
changing the fraction of charged monomers on the tails. This suggests a
physical mechanism of chromatin compaction where the degree of DNA condensation
can be controlled via biochemical means, namely the acetylation and
deacetylation of lysines in the histone tails.Comment: 4 pages, 5 figures, submitte
Temperature and orientation dependence of kinetic roughening during homoepitaxy: A quantitative x-ray-scattering study of Ag
URL:http://link.aps.org/doi/10.1103/PhysRevB.54.17938
DOI:10.1103/PhysRevB.54.17938Kinetic roughening during homoepitaxial growth was studied for Ag(111) and Ag(001). For Ag(111), from 150 to 500 K, the rms roughness exhibits a power law, σ∝tβ over nearly three decades in thickness. β≈1/2 at low temperatures, and there is an abrupt transition to smaller values above 300 K. In contrast, Ag(001) exhibits layer-by-layer growth with a significantly smaller β. These results are the first to establish the evolution of surface roughness quantitatively for a broad thickness and temperature range, as well as for the case where growth kinetics are dominated by a step-ledge diffusion barrier.Support is acknowledged from the University of Missouri Research Board, the NSF under Contract Nos. DMR-9202528 and DMR-9623827, and the Midwest Superconductivity Consortium ~MISCON! under DOE Grant No. DE-FG02-90ER45427. The SUNY X3 beamline is supported by the DOE under Contract No. DE-FG02-86ER45231, and the NSLS is supported by the DOE, Div. of Materials Sciences and Div. of Chemical Sciences. One of us
~W.C.E.! acknowledges support from the GAANN program of the U.S. Department of Education. We thank Ian Robinson for the Ag~111! crystal
Exact Analytical Bit Error Rates for Multiple Access Chaos-Based Communication Systems
Path integral Monte Carlo simulations of silicates
We investigate the thermal expansion of crystalline SiO in the --
cristobalite and the -quartz structure with path integral Monte Carlo
(PIMC) techniques. This simulation method allows to treat low-temperature
quantum effects properly. At temperatures below the Debye temperature, thermal
properties obtained with PIMC agree better with experimental results than those
obtained with classical Monte Carlo methods.Comment: 27 pages, 10 figures, Phys. Rev. B (in press
Rate- and State-Dependent Friction Law and Statistical Properties of Earthquakes
In order to clarify how the statistical properties of earthquakes depend on
the constitutive law characterizing the stick-slip dynamics, we make an
extensive numerical simulation of the one-dimensional spring-block model with
the rate- and state-dependent friction law. Both the magnitude distribution and
the recurrence-time distribution are studied with varying the constitutive
parameters characterizing the model. While a continuous spectrum of seismic
events from smaller to larger magnitudes is obtained, earthquakes described by
this model turn out to possess pronounced ``characteristic'' features.Comment: Minor revisions are made in the text and in the figures. Accepted for
publication in Europhys. Letter
Bifurcation Boundary Conditions for Switching DC-DC Converters Under Constant On-Time Control
Sampled-data analysis and harmonic balance analysis are applied to analyze
switching DC-DC converters under constant on-time control. Design-oriented
boundary conditions for the period-doubling bifurcation and the saddle-node
bifurcation are derived. The required ramp slope to avoid the bifurcations and
the assigned pole locations associated with the ramp are also derived. The
derived boundary conditions are more general and accurate than those recently
obtained. Those recently obtained boundary conditions become special cases
under the general modeling approach presented in this paper. Different analyses
give different perspectives on the system dynamics and complement each other.
Under the sampled-data analysis, the boundary conditions are expressed in terms
of signal slopes and the ramp slope. Under the harmonic balance analysis, the
boundary conditions are expressed in terms of signal harmonics. The derived
boundary conditions are useful for a designer to design a converter to avoid
the occurrence of the period-doubling bifurcation and the saddle-node
bifurcation.Comment: Submitted to International Journal of Circuit Theory and Applications
on August 10, 2011; Manuscript ID: CTA-11-016
Effects on the immune system associated with living near a pesticide dump site.
In this paper, we report results of the second phase of a larger study designed to evaluate the effects on the immune system of living near a Superfund site containing organochlorine pesticides, volatile organic compounds, and metals. Phase II was conducted to determine whether living near the site, consisting of six locations in Aberdeen, North Carolina, is associated with higher plasma organochlorine levels, immune suppression, or DNA damage. Each of 302 residents of Aberdeen and neighboring communities provided a blood specimen, underwent a skin test, and answered a questionnaire. Blood specimens were analyzed for organochlorine pesticides, immune markers, and micronuclei. Of 20 organochlorines tested, only DDE was detected in the blood of participants (except for one individual). Age-adjusted mean plasma DDE levels were 4.05 ppb for Aberdeen residents and 2.95 ppb (p = 0.01) for residents of neighboring communities. Residents of 40-59 years of age who lived within a mile of any site, but particularly the Farm Chemicals site, had higher plasma DDE levels than residents who lived farther away. Residents who lived near the Farm Chemicals site before versus after 1985 also had higher plasma DDE levels. Overall, there were few differences in immune markers between residents of Aberdeen and the neighboring communities. However, residents who lived closer to the dump sites had statistically significantly lower mitogen-induced lymphoproliferative activity than residents who lived farther away (p < 0.05). Residential location was not consistently associated with frequency of micronuclei or skin test responses. Although some statistically significant differences in immune markers were noted in association with residential location, the magnitude of effects are of uncertain clinical importance
Crystal-like high frequency phonons in the amorphous phases of solid water
The high frequency dynamics of low- (LDA) and high-density amorphous-ice
(HDA) and of cubic ice (I_c) has been measured by inelastic X-ray Scattering
(IXS) in the 1-15 nm^{-1} momentum transfer (Q) range. Sharp phonon-like
excitations are observed, and the longitudinal acoustic branch is identified up
to Q = 8nm^{-1} in LDA and I_c and up to 5nm^{-1} in HDA. The narrow width of
these excitations is in sharp contrast with the broad features observed in all
amorphous systems studied so far. The "crystal-like" behavior of amorphous
ices, therefore, implies a considerable reduction in the number of decay
channels available to sound-like excitations which is assimilated to low local
disorder.Comment: 4 pages, 3 figure
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