How University Departmens respond to the Rise of Academic Entrepreneurship? The Pasteur's Quadrant Explanation

This paper examines how universities can develop a new organizational structure to cope with the rise of academic entrepreneurship. By deploying the Pasteurian quadrant framework, knowledge creation and knowledge utilization in universities are measured. The relationships between university antecedents, Pasteurian orientation, and research performance are analyzed. A survey of university administrators and faculty members collected 634 responses from faculty members in 99 departments among 6 universities. The findings indicate that university antecedents of strategic flexibility and balancing commitment contribute to a greater Pasteurian orientation in university departments. The higher degree of Pasteurian orientation has significantly positive impacts on the performance both of knowledge creation and knowledge utilization. Moreover, the Pasteurian orientation acts as a mediator between university antecedents and research performance. Using cluster analysis, the departments are categorized into four groups. The differences between university- and department- factors in these four groups are examined and discussed. We conclude that not all university departments should move toward the Pasteurian group, and there are specific organizational and disciplinary factors resulting in mobility barriers among groups. Policies to encourage academic entrepreneurship should consider these mobility barriers, along with this new governance of science.Academic entrepreneurship, Pasteur’s quadrant, research excellence, research commercialization

On monitoring of multiple non-linear profiles

Most state-of-the-art profile monitoring methods involve studies of one profile. However, a process may contain several sensors or probes that generate multiple profiles over time. Quality characteristics presented in multiple profiles may be related multiple aspects of product or process quality. Existing charting methods for simultaneous monitoring of each multiple profile may result in high false alarm rates. Or worse, they cannot correctly detect potential relationship changes among profiles. In this study, we propose two approaches to detect process shifts in multiple non-linear profiles. A simulation study was conducted to evaluate the performance of the proposed approaches in terms of average run length under different process shift scenarios. Pros and cons of the proposed methods are discussed. A guideline for choosing the proposed methods is introduced. In addition, a hybrid method combining the salient points of both approaches is explored. Finally, a real-world data-set from a vulcanisation process is used to demonstrate the implementation of the proposed methods

How do students from different disciplines perceive the concept of “data”?: A visual elicitation method

Transforming the iSquare draw-and-write technique into the dSquare draw-and-tell approach, we conducted synchronous online visual-elicitation inter-views with 37 college students in six different disciplines to examine how they perceived the concept of “data.” The preliminary findings showed that students across disciplines tend to use group diagrams to present ICT and print materials in their dSquares. When explaining their drawings, students typically relate to functional purposes in academic contexts. While students typically use data in coursework or other work-related contexts in a positive way, students in different disciplines consider data in different original forms and use different types of metaphors to express the concept of data. While science students tend to include files or lab tools and describe data processing through the tools, humanities and social science students tend to include texts or secondary sources and describe data processing or application through personal thinking. Future research suggestions are provided based on the findings

Water Resources Management in Practices at National Pingtung University of Science and Technology Campus

NPUST was the top Taiwan university for the 9th consecutive year on the UI GreenMetric World University Ranking, and placed 27th out of 1,050 schools from 85 countries. This achievement is the result of our commitments to sustainable development. NPUST has been building green transportation for carbon and air pollution reduction, green energy system for effective use of electricity generated by renewable energy, and campus waste water recycling system for the goal of zero discharge. We also implement policies on waste reduction and waste sorting and recycling, as well as encourage planting in school campus. The practice of water resources management is crucial in various aspects that contribute to this sustainable campus. The sustainable management strategies include water consumption management, water conservation and water saving, and water recycling management. In this paper, we are going to share our practical experience in waste water treatment, recycling system set-up, waste water reuse, sustainable development for water resources and how we implement the policies on water saving at campus and spread water resources knowledge. The information is prov

A DESIGN OF OPTIMUM SCREENING PROCEDURE USING SURROGATE VARIABLE

[[abstract]]In this article, a new profit function based on a surrogate variable of its performance variable is provided to develop an optimum screening procedure for manufacturing. The optimum screening procedure helps producers set up the mean level of manufacturing and the screening limits of a surrogate variable to reach a maximum expected profit per unit. The proposed method is useful when the products in the manufacturing process are classified into different grades and sold in two alternate markets. A cement-packing example is used to illustrate the proposed method, and a numerical study is conducted to evaluate the effects of cost components and distribution parameters on the expected profit per unit. The proposed screening procedure provides a significant improvement over existing methods in term of higher expected profit per unit.[[notice]]補正完畢[[journaltype]]國外[[booktype]]紙本[[countrycodes]]SG

Transgenic mice exhibiting inducible and spontaneous Cre activities driven by a bovine keratin 5 promoter that can be used for the conditional analysis of basal epithelial cells in multiple organs

<p>Abstract</p> <p>Background</p> <p>Cre/<it>lox</it>P-mediated genetic modification is the most widely used conditional genetic approach used in the mouse. Engineered Cre and the mutated ligand-binding domain of estrogen receptor fusion recombinase (CreER^T) allow temporal control of Cre activity.</p> <p>Results</p> <p>In this study, we have generated two distinct transgenic mouse lines expressing CreER^T, which show 4-hydroxytamoxifen (4-OHT)-inducible and spontaneous (4-OHT-independent) Cre activities, referred to <it>Tg(BK5-CreER</it>^<it>T</it><it>)I </it>and <it>Tg(BK5-CreER</it>^<it>T</it><it>)S</it>, respectively. The transgenic construct is driven by the bovine Keratin 5 promoter, which is active in the basal epithelial lineage of stratified and pseudo-stratified epithelium across multiple organs. Despite the difference in 4-OHT dependency, the <it>Tg(BK5-CreER</it>^<it>T</it><it>)I </it>and <it>Tg(BK5-CreER</it>^<it>T</it><it>)S </it>mouse lines shared similar Cre-mediated recombination among various organs, except for unique mammary epithelial Cre activity in <it>Tg(BK5-CreER</it>^<it>T</it><it>)S </it>females.</p> <p>Conclusion</p> <p>These two new transgenic mouse lines for the analysis of basal epithelial function and for the genetic modification have been created allowing the identification of these cell lineages and analysis of their differentiation during embryogenesis, during perinatal development and in adult mice.</p

Surface scattering mechanisms of tantalum nitride thin film resistor

In this letter, we utilize an electrical analysis method to develop a TaN thin film resistor with a stricter spec and near-zero temperature coefficient of resistance (TCR) for car-used electronic applications. Simultaneously, we also propose a physical mechanism mode to explain the origin of near-zero TCR for the TaN thin film resistor (TFR). Through current fitting, the carrier conduction mechanism of the TaN TFR changes from hopping to surface scattering and finally to ohmic conduction for different TaN TFRs with different TaN microstructures. Experimental data of current–voltage measurement under successive increasing temperature confirm the conduction mechanism transition. A model of TaN grain boundary isolation ability is eventually proposed to influence the carrier transport in the TaN thin film resistor, which causes different current conduction mechanisms

Glial βii spectrin contributes to paranode formation and maintenance

Action potential conduction along myelinated axons depends on high densities of voltage-gated Na channels at the nodes of Ranvier. Flanking each node, paranodal junctions (paranodes) are formed between axons and Schwann cells in the peripheral nervous system (PNS) or oligodendrocytes intheCNS. Paranodal junctions contribute to both no deassembly and maintenance. Despitetheir importance, the molecular mechanisms responsible for paranode assembly and maintenance remain poorly understood. βII spectrin is expressed in diverse cells and is an essential part of the submembranous cytoskeleton. Here, we show that Schwann cell βII spectrin is highly enriched at paranodes. To elucidate the roles of glial βII spectrin, we generated mutant mice lacking βII spectrin in myelinating glial cells by crossing mice with a floxed allele of Sptbn1 with Cnp-Cre mice, and analyzed both male and female mice. Juvenile (4 weeks) and middle-aged (60 weeks) mutant mice showed reduced grip strength and sciatic nerve conduction slowing, whereas no phenotype was observed between 8 and 24 weeks of age. Consistent with these findings, immunofluorescence microscopy revealed disorganized paranodes in the PNS and CNS of both postnatal day 13 and middle-aged mutant mice, but not in young adult mutant mice. Electron microscopy confirmed partial loss of transverse bands at the paranodal axoglial junction in the middle-aged mutant mice in both the PNS and CNS. These findings demonstrate that a spectrin-based cytoskeleton in myelinating glia contributes to formation and maintenance of paranodal junctions.Fil: Susuki, Keiichiro. Baylor College of Medicine; Estados UnidosFil: Zollinger, Daniel R.. Baylor College of Medicine; Estados UnidosFil: Chang, Kae Jiun. Baylor College of Medicine; Estados UnidosFil: Zhang, Chuansheng. Baylor College of Medicine; Estados UnidosFil: Huang, Claire Yu Mei. Baylor College of Medicine; Estados UnidosFil: Tsai, Chang Ru. Baylor College of Medicine; Estados UnidosFil: Galiano, Mauricio Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina. Baylor College of Medicine; Estados UnidosFil: Liu, Yanhong. Baylor College of Medicine; Estados UnidosFil: Benusa, Savannah D.. Virginia Commonwealth University; Estados UnidosFil: Yermakov, Leonid M.. Wright State University; Estados UnidosFil: Griggs, Ryan B.. Wright State University; Estados UnidosFil: Dupree, Jeffrey L.. Virginia Commonwealth University; Estados UnidosFil: Rasband, Matthew N.. Baylor College of Medicine; Estados Unido

miRNA arm selection and isomiR distribution in gastric cancer

BACKGROUND: MicroRNAs (miRNAs) are small non-protein-coding RNAs. miRNA genes need several biogenesis steps to form function miRNAs. However, the precise mechanism and biology involved in the mature miRNA molecules are not clearly investigated. In this study, we conducted in-depth analyses to examine the arm selection and isomiRs using NGS platform. METHODS: We sequenced small RNAs from one pair of normal and gastric tumor tissues with Solexa platform. By analyzing the NGS data, we quantified the expression profiles of miRNAs and isomiRs in gastric tissues. Then, we measured the expression ratios of 5p arm to 3p arm of the same pre-miRNAs. And, we used Kolmogorov-Smirnov (KS) test to examine isomiR pattern difference between tissues. RESULTS: Our result showed the 5p arm and 3p arm miRNA derived from the same pre-miRNAs have different tissue expression preference, one preferred normal tissue and the other preferred tumor tissue, which strongly implied that there could be other mechanism controlling mature miRNA selection in addition to the known hydrogen-bonding selection rule. Furthermore, by using the KS test, we demonstrated that some isomiR types preferentially occur in normal gastric tissue but other types prefer tumor gastric tissue. CONCLUSIONS: Arm selections and isomiR patterns are significantly varied in human cancers by using deep sequencing NGS data. Our results provided a novel research topic in miRNA regulation study. With advanced bioinformatics and molecular biology studies, more robust conclusions and insight into miRNA regulation can be achieved in the near future

New Graduate Nurses’ Clinical Competence, Clinical Stress, and Intention to Leave: A Longitudinal Study in Taiwan

This longitudinal research study aimed to develop a pregraduation clinical training program for nursing students before graduation and evaluate its effect on students’ self-perceived clinical competence, clinical stress, and intention to leave current job. A sample of 198 students returned the questionnaires before and after the program. They were followed up at 3, 6, and 12 months after graduation. Results showed that posttest clinical competence was significantly higher than pretest competence, positively related to clinical competence at 3 and 12 months, and negatively related to clinical stress at 3 months. The clinical competence at 3 months was positively related to clinical competence at 6 and 12 months, and clinical competence at 6 months was related to intention to leave at 12 months. Intention to leave at 6 months was positively related to intention to leave at 3 and 12 months. Clinical stress at 3 months was positively related to clinical stress at 6 and 12 months, but not related to intention to leave at any time points. The training program improved students’ clinical competence. The stressful time that was correlated with new graduate nurses’ intention to leave their job was between the sixth and twelfth months after employment