Design and Development of Personal GeoServices for Universities

Personal GeoServices are emerging as an interaction paradigm linking users to information rich environments like a university campus or to Big Data sources like the Internet of Things by delivering spatially intelligent web-services. OpenStreetMap (OSM) constitutes a valuable source of spatial base-data that can be extracted, integrated, and utilised with such heterogeneous data sources for free. In this paper, we present a Personal GeoServices application built on OSM spatial data and university-specific business data for staff, faculty, and students. While generic products such as Google Maps and Google Earth enable basic forms of spatial exploration, the domain of a university campus presents specific business information needs, such as “What classes are scheduled in that room over there?” and “How can I get to Prof. Murray’s office from here?” Within the framework of the StratAG project (www.StratAG.ie), an eCampus Demonstrator was developed for the National University of Ireland Maynooth (NUIM) to assist university users in exploring and analysing their surroundings within a detailed data environment. This work describes this system in detail, discussing the usage of OSM vector data, and providing insights for developers of spatial information systems for personalised visual exploration of an area

On some multiplicity and mixed multiplicity formulas (Forum Math. 26(2014), 413-442)

This paper gives the additivity and reduction formulas for mixed multiplicities of multi-graded modules $M$ and mixed multiplicities of arbitrary ideals, and establishes the recursion formulas for the sum of all the mixed multiplicities of $M.$ As an application of these formulas we get the recursion formulas for the multiplicity of multi-graded Rees modules

Developing Historic Building Information Modelling Guidelines and Procedures for Architectural Heritage in Ireland

Cultural heritage researchers have recently begun applying Building Information Modelling (BIM) to historic buildings. The model is comprised of intelligent objects with semantic attributes which represent the elements of a building structure and are organised within a 3D virtual environment. Case studies in Ireland are used to test and develop the suitable systems for (a) data capture/digital surveying/processing (b) developing library of architectural components and (c) mapping these architectural components onto the laser scan or digital survey to relate the intelligent virtual representation of a historic structure (HBIM). While BIM platforms have the potential to create a virtual and intelligent representation of a building, its full exploitation and use is restricted to narrow set of expert users with access to costly hardware, software and skills. The testing of open BIM approaches in particular IFCs and the use of game engine platforms is a fundamental component for developing much wider dissemination. The semantically enriched model can be transferred into a WEB based game engine platform

Monitoring Deformations of a Wooden Church Tower by Laser Scanning

Churches are part of heritage structures that take an important role in Europe's cultural identity. As such, these structures must be protected to prevent catastrophic collapse and any damage must be reported timely to establish planning to maintenance and restoration. This can be achievable when the churches are monitored periodically with regular intervals. However, this monitoring strategy has not been available in most of the Europe’s churches for a number of reasons, complexity of the structures and limited budget are just two of them. Laser scanning has been widely used in capturing rich three-dimensional (3D) topographic data of visible surfaces of a structure with high accuracy. This paper presents a methodology to determine the shape and possible deviation from verticality of the church’s tower for monitoring deformation using a terrestrial laser scanner. The 500-year old wooden tower of St. Bavo Church in Haarlem, Netherlands is selected as a case study. First, point clouds of the tower captured from different views are registered into the same coordinate system. Second, a RANSAC method is employed to extract point clouds of a whole façades of the tower. Next, a point and surface-based method is proposed to compute the deformation of the surface from its data points. The results indicate that there is slightly different deformation between the tower facades in the same story and in neighbour stories. Moreover, the maximum total relative deformation at Story 7 of the tower by 0.63m

Clinical value of prostate segmentation and volume determination on MRI in benign prostatic hyperplasia

Benign prostatic hyperplasia (BPH) is a nonmalignant pathological enlargement of the prostate, which occurs primarily in the transitional zone. BPH is highly prevalent and is a major cause of lower urinary tract symptoms in aging males, although there is no direct relationship between prostate volume and symptom severity. The progression of BPH can be quantified by measuring the volumes of the whole prostate and its zones, based on image segmentation on magnetic resonance imaging. Prostate volume determination via segmentation is a useful measure for patients undergoing therapy for BPH. However, prostate segmentation is not widely used due to the excessive time required for even experts to manually map the margins of the prostate. Here, we review and compare new methods of prostate volume segmentation using both manual and automated methods, including the ellipsoid formula, manual planimetry, and semiautomated and fully automated segmentation approaches. We highlight the utility of prostate segmentation in the clinical context of assessing BPH

Assessing unmodified 70-mer oligonucleotide probe performance on glass-slide microarrays

BACKGROUND: Long oligonucleotide microarrays are potentially more cost- and management-efficient than cDNA microarrays, but there is little information on the relative performance of these two probe types. The feasibility of using unmodified oligonucleotides to accurately measure changes in gene expression is also unclear. RESULTS: Unmodified sense and antisense 70-mer oligonucleotides representing 75 known rat genes and 10 Arabidopsis control genes were synthesized, printed and UV cross-linked onto glass slides. Printed alongside were PCR-amplified cDNA clones corresponding to the same genes, enabling us to compare the two probe types simultaneously. Our study was designed to evaluate the mRNA profiles of heart and brain, along with Arabidopsis cRNA spiked into the labeling reaction at different relative copy number. Hybridization signal intensity did not correlate with probe type but depended on the extent of UV irradiation. To determine the effect of oligonucleotide concentration on hybridization signal, 70-mers were serially diluted. No significant change in gene-expression ratio or loss in hybridization signal was detected, even at the lowest concentration tested (6.25 μm). In many instances, signal intensity actually increased with decreasing concentration. The correlation coefficient between oligonucleotide and cDNA probes for identifying differentially expressed genes was 0.80, with an average coefficient of variation of 13.4%. Approximately 8% of the genes showed discordant results with the two probe types, and in each case the cDNA results were more accurate, as determined by real-time PCR. CONCLUSIONS: Microarrays of UV cross-linked unmodified oligonucleotides provided sensitive and specific measurements for most of the genes studied

Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin

Regulatory T cells (Tregs) are required to establish immune tolerance to commensal microbes. Tregs accumulate abruptly in the skin during a defined window of postnatal tissue development. However, the mechanisms mediating Treg migration to neonatal skin are unknown. Here we show that hair follicle (HF) development facilitates the accumulation of Tregs in neonatal skin and that upon skin entry these cells localize to HFs, a primary reservoir for skin commensals. Further, germ-free neonates had reduced skin Tregs indicating that commensal microbes augment Treg accumulation. We identified Ccl20 as a HF-derived, microbiota-dependent chemokine and found its receptor, Ccr6, to be preferentially expressed by Tregs in neonatal skin. The Ccl20-Ccr6 pathway mediated Treg migration in vitro and in vivo. Thus, HF morphogenesis, commensal microbe colonization, and local chemokine production work in concert to recruit Tregs into neonatal skin, thereby establishing this tissue Treg niche early in life

Toward a client-centered benchmark for self-sufficiency: Evaluating the ‘process’ of becoming job ready.

The purpose of this study is to evaluate how service providers, clients, and graduates of a job training program define the term self-sufficiency (SS). This community-engaged, mixed method study qualitatively analyzes focus group data from each group and quantitatively examines survey data obtained from participants of the program. Findings reveal that psychological transformation as a ‘process’ represents the emic definition of SS—psychological SS—but each dimension of the concept is reflected in varying degrees by group. Provider and participant views are vastly different from the outcome-driven policy and funder definitions. Implications for benchmarking psychological SS as an empowerment-based ‘process’ measure of job readiness in workforce development evaluation are discussed

The phylodynamics of SARS-CoV-2 during 2020 in Finland

Finland has had a low incidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infections as compared to most European countries. Here we report the origins and turnover of SARS-CoV-2 lineages circulating in Finland in 2020. SARS-CoV-2 introduced to Finland in January 2020 and spread rapidly across southern Finland during spring. We observed rapid turnover among Finnish lineages during this period. Clade 20C became the most prevalent among sequenced cases and was replaced by other strains in fall 2020. Bayesian phylogeographic reconstructions suggested 42 independent introductions into Finland during spring 2020, mainly from Italy, Austria, and Spain, which might have been the source for a third of cases. The investigations of the original introductions of SARS-CoV-2 to Finland during the early stages of the pandemic and of the subsequent lineage dynamics could be utilized to assess the role of transboundary movements and effects of early intervention and public health measures.Peer reviewe

Introductory programming: a systematic literature review

As computing becomes a mainstream discipline embedded in the school curriculum and acts as an enabler for an increasing range of academic disciplines in higher education, the literature on introductory programming is growing. Although there have been several reviews that focus on specific aspects of introductory programming, there has been no broad overview of the literature exploring recent trends across the breadth of introductory programming. This paper is the report of an ITiCSE working group that conducted a systematic review in order to gain an overview of the introductory programming literature. Partitioning the literature into papers addressing the student, teaching, the curriculum, and assessment, we explore trends, highlight advances in knowledge over the past 15 years, and indicate possible directions for future research