5,470 research outputs found
Comparative Analysis Of Zebrafish And Planarian Model Systems For Developmental Neurotoxicity Screens Using An 87-Compound Library
There is a clear need to establish and validate new methodologies to more quickly and efficiently screen chemicals for potential toxic effects, particularly on development. The emergence of alternative animal systems for rapid toxicology screens presents valuable opportunities to evaluate how systems complement each other. In this article, we compare a chemical library of 87-compounds in two such systems, developing zebrafish and freshwater planarians, by screening for developmental neurotoxic effects. We show that the systems’ toxicological profiles are complementary to each other, with zebrafish yielding more detailed morphological endpoints and planarians more behavioral endpoints. Overall, zebrafish was more sensitive to this chemical library, yielding 86/87 hits, compared to 50/87 hits in planarians. The difference in sensitivity could not be attributed to molecular weight, Log Kow or the bioconcentration factor. Of the 87 chemicals, 28 had previously been evaluated in mammalian developmental neuro- (DNT), neuro- or developmental toxicity studies. Of the 28, 20 were hits in the planarian, and 27 were hits in zebrafish. Eighteen of the 28 had previously been identified as DNT hits in mammals and were highly associated with activity in zebrafish and planarian behavioral assays in this study. Only 1 chemical (out of 28) was a false negative in both zebrafish and planarian systems. Differences in endpoint coverage and system sensitivity illustrate the value of a dual systems approach to rapidly query a large chemical-bioactivity space and provide weight-of-evidence for prioritization of chemicals for further testing
Review of finite fields: Applications to discrete Fourier, transforms and Reed-Solomon coding
An attempt is made to provide a step-by-step approach to the subject of finite fields. Rigorous proofs and highly theoretical materials are avoided. The simple concepts of groups, rings, and fields are discussed and developed more or less heuristically. Examples are used liberally to illustrate the meaning of definitions and theories. Applications include discrete Fourier transforms and Reed-Solomon coding
Excitation spectroscopy of single quantum dots at tunable positive, neutral and negative charge states
We present a comprehensive study of the optical transitions and selection
rules of variably charged single self-assembled InAs/GaAs quantum dots. We
apply high resolution polarization sensitive photoluminescence excitation
spectroscopy to the same quantum dot for three different charge states: neutral
and negatively or positively charged by one additional electron or hole. From
the detailed analysis of the excitation spectra, a full understanding of the
single-carrier energy levels and the interactions between carriers in these
levels is extracted for the first time.Comment: 8 pages, 5 figure
Measuring shell resonances of spherical acoustic resonators
International audienceCoupling between gas and shell is a concern in the experiment used at LNE-CNAM to determine the Boltzmann constant kB by an acoustic method. As the walls of real resonators are not perfectly ridig, some perturbations occur in the frequency range of the acoustic resonances measured within helium gas contained in the caivity. As a contribution for a better understanding of the phenomenon, we have built an experiment to measure the shell modes of the spherical resonators in use in our laboratory. We report here a work in progress to assess these modes using a hammer blow method together with modal analysis. The study is carried out with air-filled, copper-walled, half-litre quasi-spherical resonator in the frequency range from 1 Hz to 20 kHz. Our results show that the shell modes expand into multiple resonances of similar modal shape, including the "breathing" mode. We confirm the observations reported in other works [4,6] of shell perturbations at other frequencies than the breathing frequency
Investigation of phonon behavior in Pr2NiMnO6 by micro-Raman spectroscopy
The temperature dependence of phonon excitations and the presence of spin
phonon coupling in polycrystalline Pr2NiMnO6 samples were studied using
micro-Raman spectroscopy and magnetometry. Magnetic properties show a single
ferromagnetic-to-paramagnetic transition at 228 K and a saturation
magnetization close to 4.95 \muB/f.u.. Three distinct Raman modes at 657, 642,
and 511 cm-1 are observed. The phonon excitations show a clear hardening due to
anharmonicity from 300 K down to 10 K. Further, temperature dependence of the
657 cm-1 mode shows only a small softening. This reflects the presence of a
relatively weak spin-phonon coupling in Pr2NiMnO6 contrary to other double
perovskites previously studied.Comment: 10 pages, 4 fig
Powertrain modelling for engine stop-start dynamics and control of micro/mild hybrid construction machines
Engine stop-start control is considered as the key technology for micro/mild hybridisation of vehicles and machines. To utilize this concept, especially for construction machines, the engine is desired to be started in such a way that the operator discomfort can be minimized. To address this issue, this paper aims to develop a simple powertrain modelling approach for engine stop-start dynamic analysis and an advanced engine start control scheme newly applicable for micro/mild hybrid construction machines. First, a powertrain model of a generic construction machine is mathematically developed in a general form which allows to investigate the transient responses of the system during the engine cranking process. Second, a simple parameterisation procedure with a minimum set of data required to characterise the dynamic model is presented. Third, a model- based adaptive controller is designed for the starter to crank the engine quickly and smoothly without the need of fuel injection while the critical problems of machine noise, vibration and harshness can be eliminated. Finally, the advantages and effectiveness of the proposed modelling and control approaches have been validated through numerical simulations. The results imply that with the limited data set for training, the developed model works better than a high fidelity model built in AMESim while the adaptive controller can guarantee the desired cranking performance
The Effect of Neonatal Leptin Antagonism in Male Rat Offspring Is Dependent upon the Interaction between Prior Maternal Nutritional Status and Post-Weaning Diet
Epidemiological and experimental studies report associations between overweight mothers and increased obesity risk in offspring. It is unclear whether neonatal leptin regulation mediates this association between overweight mothers and offspring obesity. We investigated the effect of neonatal treatment with a leptin antagonist (LA) on growth and metabolism in offspring of mothers fed either a control or a high fat diet. Wistar rats were fed either a control (CON) or a high fat diet (MHF) during pregnancy and lactation. Male CON and MHF neonates received either saline (S) or a rat-specific pegylated LA on days 3, 5, and 7. Offspring were weaned onto either a control or a high fat (hf) diet. At day 100, body composition, blood glucose, β-hydroxybutyrate and plasma leptin and insulin were determined. In CON and MHF offspring, LA increased neonatal bodyweights compared to saline-treated offspring and was more pronounced in MHF offspring. In the post-weaning period, neonatal LA treatment decreased hf diet-induced weight gain but only in CON offspring. LA treatment induced changes in body length, fat mass, body temperature, and bone composition. Neonatal LA treatment can therefore exert effects on growth and metabolism in adulthood but is dependent upon interactions between maternal and post-weaning nutrition
Cosmological hydrodynamical simulations of galaxy clusters: X-ray scaling relations and their evolution
We analyse cosmological hydrodynamical simulations of galaxy clusters to
study the X-ray scaling relations between total masses and observable
quantities such as X-ray luminosity, gas mass, X-ray temperature, and .
Three sets of simulations are performed with an improved version of the
smoothed particle hydrodynamics GADGET-3 code. These consider the following:
non-radiative gas, star formation and stellar feedback, and the addition of
feedback by active galactic nuclei (AGN). We select clusters with , mimicking the typical selection of
Sunyaev-Zeldovich samples. This permits to have a mass range large enough to
enable robust fitting of the relations even at . The results of the
analysis show a general agreement with observations. The values of the slope of
the mass-gas mass and mass-temperature relations at are 10 per cent lower
with respect to due to the applied mass selection, in the former case,
and to the effect of early merger in the latter. We investigate the impact of
the slope variation on the study of the evolution of the normalization. We
conclude that cosmological studies through scaling relations should be limited
to the redshift range , where we find that the slope, the scatter, and
the covariance matrix of the relations are stable. The scaling between mass and
is confirmed to be the most robust relation, being almost independent of
the gas physics. At higher redshifts, the scaling relations are sensitive to
the inclusion of AGNs which influences low-mass systems. The detailed study of
these objects will be crucial to evaluate the AGN effect on the ICM.Comment: 24 pages, 11 figures, 5 tables, replaced to match accepted versio
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