Overheating Risks and Adaptation Strategies of Energy Retrofitted Historic Buildings under the Impact of Climate Change: Case Studies in Alpine Region

Energy retrofits can enhance the liveability and efficiency of historic buildings while preserving their historic and aesthetic values. However, measures like improved insulation and airtightness may increase their vulnerability to overheating and climate change may further worsen their performance in the future. This paper investigates indoor overheating risks brought by climate change in retrofitted historic buildings and proposes effective adaptation strategies. Firstly, local weather conditions are analysed to identify homogenous climatic zones. For each climatic zone, "a business-as-usual" emissions scenario is adopted, and most representative regional climate models are selected to obtain hourly output of future climate projection. A comparative study is adopted where typical alpine residential buildings, "Portici house", are simulated with regard to future energy use and indoor thermal state using the dynamic model in EnergyPlus. Energy use and indoor thermal conditions are compared before and after energy retrofit, as well as under present and future climate conditions. The results demonstrate that retrofit interventions could significantly improve energy efficiency of historic buildings in both present and future scenarios. A change in climate together with retrofit interventions will, however, result in higher risk of indoor overheating in South Tyrol. Potential negative side effects of energy retrofit could be controlled by adopting adequate shading and ventilation approaches that minimise, or eliminate, the risk of overheating during high temperature periods while optimising historic buildings' energy performance

Thermal Modeling of a Historical Building Wall: Using Long-Term Monitoring Data to Understand the Reliability and the Robustness of Numerical Simulations

Thermal modeling of building components plays a crucial role in designing energy efficiency measures, assessing living comfort, and preventing building damages. The accuracy of the modeling process strongly depends on the reliability of the physical models and the correct selection of input parameters, especially for historic buildings where uncertainties on wall composition and material properties are higher. This work evaluates the reliability of building thermal modeling and identifies the input parameters that most affect the simulation results. A monitoring system is applied to a historic building wall to measure the temperature profile. The long-term dataset is compared with the result of a simulation model. A sensitivity analysis is applied for the determination of the influential input parameters. A two-step optimization is performed to calibrate the numerical model: the first optimization step is based on an optimized selection of the database materials, while the second optimization step uses a particle swarm algorithm. The results indicate that the output of the simulation model is largely influenced by the coefficients describing the coupling with the boundary conditions and by the thermal conductivities of the materials. Very good results are obtained already after the first optimization step ((Formula presented.) while the second optimization step improves further the agreement ((Formula presented.). The parameter values reported in the datasheets do not match those found through optimization. Even with extensive optimization using an algorithm, starting with monitoring data is insufficient to identify material parameter values

Applied Research of the hygrothermal behaviour of an internally insulated historicwall without vapour barrier: In situ measurements and dynamic simulations

The hygrothermal behaviour of an internally insulated historic wall is still hard to predict, mainly because the physical characteristics of the materials composing the historic wall are unknown. In this study, the hygrothermal assessment of an internally thermal insulated masonry wall of an historic palace located in Ferrara, in Italy, is shown. In situ non-destructive monitoring method is combined with a hygrothermal simulation tool, aiming to better analyse and discuss future refurbishment scenarios. In this context, the original U-value of the wall (not refurbished) is decreased from 1.44W/m2K to 0.26W/m2K (10 cm stone wool). Under the site specific conditions of this wall, not reached by the sun or rain, it was verified that even in the absence of vapour barrier, no frost damage is likely to occur and the condensation risk is very limited. Authors proposed further discussion based on simulation. The results showed that the introduction of a second gypsum board to the studied technology compensated such absence, while the reduction of the insulation material thickness provides a reduction of RH peaks in the interstitial area by 1%; this second solution proved to be more efficient, providing a 3% RH reduction and the avoidance of further thermal losses

Congenital Hypothyroidism Long‐Term Follow‐up Project: Navigating the Rough Waters of a Multi‐Center, Multi‐State Public Health Project

The Region 4 Midwest Genetics Collaborative, made up of seven regional states (Illinois, Indiana, Kentucky, Michigan, Minnesota, Ohio, and Wisconsin), brought together pediatric endocrinologists, state laboratory experts, public health follow‐up specialists, and parents of children with congenital hypothyroidism (CH) to identify the three‐year follow‐up management and education patterns of primary care clinicians and pediatric endocrinologists in the care of children diagnosed with CH by state newborn screening (NBS) programs. Among a number of challenges, each state had different NBS methods, data systems, public health laws, and institutional review board (IRB) requirements. Furthermore, the diagnosis of CH was complicated by the timing of the NBS sample, the gestational age, weight, and co‐morbidities at delivery. There were 409 children with CH identified through NBS in 2007 in the seven state region. The clinician of record and the parents of these children were invited to participate in a voluntary survey. Approximately 64 % of clinician surveys were collected with responses to questions relating to treatment, monitoring practices, educational resources, genetic counseling, and services provided to children with confirmed CH and their families. Nearly one‐quarter (24 %) of parents surveyed responded to questions relating to treatment, education, genetic counseling, resources, and services they received or would like to receive. De‐identified data from six of the seven states were compiled for analysis, with one state being unable to obtain IRB approval within the study timeline. The data from this collaborative effort will improve state follow‐up programs and aid in developing three‐year follow‐up guidelines for children diagnosed with CH. To aid in the facilitation of similar public health studies, this manuscript highlights the challenges faced, and focuses on the pathway to a successful multi‐state public health endeavor.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/147153/1/jgc40464.pd

Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells

The major-histocompatibility-complex-(MHC)-class-I-related molecule MR1 can present activating and non-activating vitamin-B-based ligands to mucosal-associated invariant T cells (MAIT cells). Whether MR1 binds other ligands is unknown. Here we identified a range of small organic molecules, drugs, drug metabolites and drug-like molecules, including salicylates and diclofenac, as MR1-binding ligands. Some of these ligands inhibited MAIT cells ex vivo and in vivo, while others, including diclofenac metabolites, were agonists. Crystal structures of a T cell antigen receptor (TCR) from a MAIT cell in complex with MR1 bound to the non-stimulatory and stimulatory compounds showed distinct ligand orientations and contacts within MR1, which highlighted the versatility of the MR1 binding pocket. The findings demonstrated that MR1 was able to capture chemically diverse structures, spanning mono- and bicyclic compounds, that either inhibited or activated MAIT cells. This indicated that drugs and drug-like molecules can modulate MAIT cell function in mammals

Mucosal-associated invariant T cells augment immunopathology and gastritis in chronic helicobacter pyloriInfection

Mucosal-associated invariant T (MAIT) cells produce inflammatory cytokines and cytotoxic granzymes in response to by-products of microbial riboflavin synthesis. Although MAIT cells are protective against some pathogens, we reasoned that they might contribute to pathology in chronic bacterial infection. We observed MAIT cells in proximity to Helicobacter pylori bacteria in human gastric tissue, and so, using MR1-tetramers, we examined whether MAIT cells contribute to chronic gastritis in a mouse H. pylori SS1 infection model. Following infection, MAIT cells accumulated to high numbers in the gastric mucosa of wild-type C57BL/6 mice, and this was even more pronounced in MAIT TCR transgenic mice or in C57BL/6 mice where MAIT cells were preprimed by Ag exposure or prior infection. Gastric MAIT cells possessed an effector memory Tc1/Tc17 phenotype, and were associated with accelerated gastritis characterized by augmented recruitment of neutrophils, macrophages, dendritic cells, eosinophils, and non-MAIT T cells and by marked gastric atrophy. Similarly treated MR1−/− mice, which lack MAIT cells, showed significantly less gastric pathology. Thus, we demonstrate the pathogenic potential of MAIT cells in Helicobacter-associated immunopathology, with implications for other chronic bacterial infections

What are the implications of climate change for retrofitted historic buildings? A literature review

Historic buildings account for more than one-quarter of Europe's existing building stock and are going to be crucial in the achievement of future energy targets. Although a drastic reduction in carbon emissions would slow climate change, an alteration in the climate is already certain. Therefore, the impact of climate change on retrofitted historic buildings should be considered in terms of occupants' comfort, heritage conservation, and energy performance. Inappropriate interventions might weaken the potential of traditional climate adaptive solutions, such as thermal mass and night cooling, leading to higher risks of overheating in a warming climate. Similarly, retrofit solutions will change the moisture dynamics of historic envelopes, which might lead to moisture damages when combined with more extreme precipitation events. This paper reviews recent literature that provides evidence of climate change's impact on retrofitted buildings, reveals potential future risks, and thereby sheds light on new factors influencing the decision-making process in the retrofit of historic buildings

Assessing the impact of climate change on energy retrofit of alpine historic buildings: Consequences for the hygrothermal performance

Climate change will affect future hygrothermal performance of buildings. This could lead to higher risks regarding energy optimization, thermal comfort and historic building conservation depending on the local climate, building construction and retrofit solutions adopted. This paper explores the risks brought by climate change on a typical residential historic building of South Tyrol. The results obtained show that, although the climate warming will reduce the future heating energy demand, an improvement of buildings' energy performance will still be necessary to increase sustainability and ensure their continued use. Natural ventilation would suffice to prevent overheating in the studied location, but a further analysis is needed for warmer alpine regions. Regarding the moisture-related risks for the historic construction, mould growth should be considered when retrofitting a wooden wall and frost damage should be carefully studied in the case of sandstone walls