Teaching SIFT for Source Evaluation in Asynchronous One-Credit information Literacy Courses

With an awareness of growing issues in teaching source evaluation, the authors explored new methods to incorporate this skill into one-credit asynchronous information literacy courses. The authors discovered improvements in student performance when using SIFT and identified key strategies for its implementation to achieve best results

Bolstering Mission Success: Lessons Learned for Small Satellite Developers Adhering to Manned Spaceflight Requirements

This paper is meant to impart critical knowledge to new and upcoming spacecraft developers (universities, high schools, research centers, young commercial companies, etc.) regarding lessons learned that they can implement to create successful spacecraft missions. This perspective comes from NanoRacks, a “space access provider”, where we’ve gained enormous expertise on how to design and build to requirements driven by human-rated spaceflight. As we all know, operating in space is only half of the battle

A novel integrated Sachs-Wolfe effect from Early Dark Energy

We study the nonlinear effects of minimally coupled, massless, cosmological scalar fields on the cosmic microwave background (CMB). These fields can exhibit post-recombination parametric resonance and subsequent nonlinear evolution leading to novel contributions to the gravitational potential. We compute the resulting contributions to the CMB temperature anisotropies through the time-variation of the gravitational potential (i.e., the integrated Sachs-Wolfe (ISW) effect). We find that fields that constitute 5% of the total energy density and become dynamical at $z_c \simeq 10^{4}$ can produce marginally observable ISW signals at multipoles $\ell \simeq 2000$. Fields that become dynamical at earlier times and/or have initial displacements at a flatter part of their potential, produce ISW contributions that are significantly larger and at higher multipoles. We calculate these dynamics and the resulting evolution of gravitational perturbations using analytic estimates alongside detailed nonlinear lattice simulations, which couple scalar fields and cosmological fluids to a perturbed metric. Finally, we discuss the possibility of detecting these features with future high-resolution CMB observations.Comment: 12 pages, 6 figures, comments welcom

Medical Therapies for Uterine Fibroids - A Systematic Review and Network Meta-Analysis of Randomised Controlled Trials

BACKGROUND: Uterine fibroids are common, often symptomatic and a third of women need repeated time off work. Consequently 25% to 50% of women with fibroids receive surgical treatment, namely myomectomy or hysterectomy. Hysterectomy is the definitive treatment as fibroids are hormone dependent and frequently recurrent. Medical treatment aims to control symptoms in order to replace or delay surgery. This may improve the outcome of surgery and prevent recurrence. PURPOSE: To determine whether any medical treatment can be recommended in the treatment of women with fibroids about to undergo surgery and in those for whom surgery is not planned based on currently available evidence. STUDY SELECTION: Two authors independently identified randomised controlled trials (RCT) of all pharmacological treatments aimed at the treatment of fibroids from a list of references obtained by formal search of MEDLINE, EMBASE, Cochrane library, Science Citation Index, and ClinicalTrials.gov until December 2013. DATA EXTRACTION: Two authors independently extracted data from identified studies. DATA SYNTHESIS: A Bayesian network meta-analysis was performed following the National Institute for Health and Care Excellence-Decision Support Unit guidelines. Odds ratios, rate ratios, or mean differences with 95% credible intervals (CrI) were calculated. RESULTS AND LIMITATIONS: A total of 75 RCT met the inclusion criteria, 47 of which were included in the network meta-analysis. The overall quality of evidence was very low. The network meta-analysis showed differing results for different outcomes. CONCLUSIONS: There is currently insufficient evidence to recommend any medical treatment in the management of fibroids. Certain treatments have future promise however further, well designed RCTs are needed

Gamemaster: Gamify Learning without Feeling Fake

Have you ever considered gamification as part of your pedagogy but didn\u27t trust the results or didn\u27t trust yourself to stay authentic? Join my game session! Together, we\u27ll discover how gamification can improve your classroom atmosphere and student learning when approached honestly (and how it can totally bomb when you\u27re faking). We\u27ll explore other successful games, both educational and commercial, to discover your style of fun and explore engaging game mechanics. Before we\u27re done, you\u27ll have more than a high score -- you\u27ll have a game tailored made for your coursework and your individuality

Navigating AI: Responsible Curriculum Integration of ChatGPT and Evolving AI

As AI becomes more ubiquitous, educators must ensure that their students are equipped with the necessary knowledge and skills to navigate this emerging technology responsibly. This workshop will provide educators of all technical expertise a practical understanding on Generative AI as well as a framework for integrating such technology into curricula. Participants will discover key concepts, discuss critical issues, and experiment with ChatGPT. By the end of the workshop, educators will better understand how to navigate the complex landscape of AI alongside colleagues and students and may even have instructional materials to use next semester

Modulating glioma-mediated myeloid-derived suppressor cell development with sulforaphane.

Glioblastoma is the most common primary tumor of the brain and has few long-term survivors. The local and systemic immunosuppressive environment created by glioblastoma allows it to evade immunosurveillance. Myeloid-derived suppressor cells (MDSCs) are a critical component of this immunosuppression. Understanding mechanisms of MDSC formation and function are key to developing effective immunotherapies. In this study, we developed a novel model to reliably generate human MDSCs from healthy-donor CD14+ monocytes by culture in human glioma-conditioned media. Monocytic MDSC frequency was assessed by flow cytometry and confocal microscopy. The resulting MDSCs robustly inhibited T cell proliferation. A cytokine array identified multiple components of the GCM potentially contributing to MDSC generation, including Monocyte Chemoattractive Protein-1, interleukin-6, interleukin-8, and Macrophage Migration Inhibitory Factor (MIF). Of these, Macrophage Migration Inhibitory Factor is a particularly attractive therapeutic target as sulforaphane, a naturally occurring MIF inhibitor derived from broccoli sprouts, has excellent oral bioavailability. Sulforaphane inhibits the transformation of normal monocytes to MDSCs by glioma-conditioned media in vitro at pharmacologically relevant concentrations that are non-toxic to normal leukocytes. This is associated with a corresponding increase in mature dendritic cells. Interestingly, sulforaphane treatment had similar pro-inflammatory effects on normal monocytes in fresh media but specifically increased immature dendritic cells. Thus, we have used a simple in vitro model system to identify a novel contributor to glioblastoma immunosuppression for which a natural inhibitor exists that increases mature dendritic cell development at the expense of myeloid-derived suppressor cells when normal monocytes are exposed to glioma conditioned media

Probing regolith-covered surfaces in low gravity

The surfaces of many planetary bodies, including asteroids, moons, and planets, are composed of rubble-like grains held together by varying levels of gravitational attraction and cohesive forces. Future instrumentation for operation on, and interacting with, such surfaces will require efficient and effective design principles and methods of testing. Here we present results from the EMPANADA experiment (Ejecta-Minimizing Protocols for Applications Needing Anchoring or Digging on Asteroids) which flew on several reduced gravity parabolic flights. EMPANADA studies the effects of the insertion of a flexible probe into a granular medium as a function of ambient gravity. This is done for an idealized 2D system as well as a more realistic 3D sample. To quantify the dynamics inside the 2D granular material we employ photoelasticity to identify the grain-scale forces throughout the system, while in 3D experiments we use simulated regolith. Experiments were conducted at three different levels of gravity: martian, lunar, and microgravity. In this work, we demonstrate that the photoelastic technique provides results that complement traditional load cell measurements in the 2D sample, and show that the idealized system exhibits similar behaviour to the more realistic 3D sample. We note that the presence of discrete, stick-slip failure events depends on the gravitational acceleration