Feasibility study of an Integrated Program for Aerospace vehicle Design (IPAD). Volume 6: IPAD system development and operation

The strategy of the IPAD implementation plan presented, proposes a three phase development of the IPAD system and technical modules, and the transfer of this capability from the development environment to the aerospace vehicle design environment. The system and technical module capabilities for each phase of development are described. The system and technical module programming languages are recommended as well as the initial host computer system hardware and operating system. The cost of developing the IPAD technology is estimated. A schedule displaying the flowtime required for each development task is given. A PERT chart gives the developmental relationships of each of the tasks and an estimate of the operational cost of the IPAD system is offered

The effects of multiple aerospace environmental stressors on human performance

An extended Fitt's law paradigm reaction time (RT) task was used to evaluate the effects of acceleration on human performance in the Dynamic Environment Simulator (DES) at Armstrong Laboratory, Wright-Patterson AFB, Ohio. This effort was combined with an evaluation of the standard CSU-13 P anti-gravity suit versus three configurations of a 'retrograde inflation anti-G suit'. Results indicated that RT and error rates increased 17 percent and 14 percent respectively from baseline to the end of the simulated aerial combat maneuver and that the most common error was pressing too few buttons

Probing the IGM/Galaxy Connection IV: The LCO/WFCCD Galaxy Survey of 20 Fields Surrounding UV Bright Quasars

We publish the survey for galaxies in 20 fields containing ultraviolet bright quasars (with z_em 0.1 to 0.5) that can be used to study the association between galaxies and absorption systems from the low-z intergalactic medium (IGM). The survey is magnitude limited (R~19.5 mag) and highly complete out to 10' from the quasar in each field. It was designed to detect dwarf galaxies (L ~ 0.1 L*) at an impact parameter rho 1Mpc (z=0.1) from a quasar. The complete sample (all 20 fields) includes R-band photometry for 84718 sources and confirmed redshifts for 2800 sources. This includes 1198 galaxies with 0.005 < z < (z_em - 0.01) at a median redshift of 0.18, which may associated with IGM absorption lines. All of the imaging was acquired with cameras on the Swope 40" telescope and the spectra were obtained via slitmask observations using the WFCCD spectrograph on the Dupont 100" telescope at Las Campanas Observatory (LCO). This paper describes the data reduction, imaging analysis, photometry, and spectral analysis of the survey. We tabulate the principal measurements for all sources in each field and provide the spectroscopic dataset online.Comment: Accepted to the Astrophysical Journal Supplements; 20 pages, only 6 figures shown in this version. See http://www.ucolick.org/~xavier/WFCCDOVI/index.html for a full-length manuscript and other supportive materia

Discrete element modeling and fibre optical measurements for fluidized bed spray granulation

Spout fluidized beds are frequently used for the production of granules or\ud particles through granulation. The products find application in a large variety of\ud applications, for example detergents, fertilizers, pharmaceuticals and food. Spout fluidized\ud beds have a number of advantageous properties, such as a high mobility of the particles,\ud which prevents undesired agglomeration and yields excellent heat transfer properties. The\ud particle growth mechanism in a spout fluidized bed as function of particle-droplet\ud interaction has a profound influence on the particle morphology and thus on the product\ud quality. Nevertheless, little is known about the details of the granulation process. This is\ud mainly due to the fact that the granulation process is not visually accessible. In this work\ud we use fundamental, deterministic models to enable the detailed investigation of\ud granulation behaviour in a spout fluidized bed. A discrete element model is used\ud describing the dynamics of the continuous gas-phase and the discrete droplets and\ud particles. For each element momentum balances are solved. The momentum transfer\ud among each of the three phases is described in detail at the level of individual elements.\ud The results from the discrete element model simulations are compared with local\ud measurements of particle volume fractions as well as particle velocities by using a novel\ud fibre optical probe in a fluidized bed of 400 mm I.D. Simulations and experiments were\ud carried out for two different cases using Geldart B type aluminium oxide particles: a\ud freely bubbling fluidized bed and a spout fluidized bed with the presence of droplets. It is\ud demonstrated how the discrete element model can be used to obtain information about the\ud interaction of the discrete phases, i.e. the growth zone in a spout fluidized bed. Eventually\ud this kind of information can be used to obtain closure information required in more coarse\ud grained model

Comparison of fibre optical measurements and discrete element simulations for the study of granulation in a spout fluidized bed

Spout fluidized beds are frequently used for the production of granules or particles through granulation. The products find application in a large variety of applications, for example detergents, fertilizers, pharmaceuticals and food. Spout fluidized beds have a number of advantageous properties, such as a high mobility of the particles, which prevents undesired agglomeration and yields excellent heat transfer properties. The particle growth mechanism in a spout fluidized bed as function of particle-droplet interaction has a profound influence on the particle morphology and thus on the product quality. Nevertheless, little is known about the details of the granulation process. This is mainly due to the fact that the granulation process is not visually accessible. In this work we use fundamental, deterministic models to enable the detailed investigation of granulation behaviour in a spout fluidized bed. A discrete element model is used describing the dynamics of the continuous gas-phase and the discrete droplets and particles. For each element momentum balances are solved. The momentum transfer among each of the three phases is described in detail at the level of individual elements. The results from the discrete element model simulations are compared with local measurements of particle volume fractions as well as particle velocities by using a novel fibre optical probe in a fluidized bed of 400 mm I.D. Simulations and experiments were carried out for three different cases using Geldart B type aluminium oxide particles: a freely bubbling fluidized bed; a spout fluidized bed without the presence of droplets and a spout fluidized bed with the presence of droplets. It is demonstrated how the discrete element model can be used to obtain information about the interaction of the discrete phases, i.e. the growth zone in a spout fluidized bed. Eventually this kind of information can be used to obtain closure information required in more coarse grained models

Rapid Oxidation Characterization of Ultra-High Temperature Ceramics

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65673/1/j.1551-2916.2007.01861.x.pd

Rho iso-alpha acids from hops inhibit the GSK-3/NF-κB pathway and reduce inflammatory markers associated with bone and cartilage degradation

<p>Abstract</p> <p>Background</p> <p><it>Rho </it>iso-alpha acids (RIAA) from hops have been shown to have anti-inflammatory properties. To understand the mechanisms, we evaluated the effect of RIAA in cell signaling pathways and inflammatory markers using various in vitro models. We also investigated their therapeutic effect in mice with collagen-induced arthritis.</p> <p>Methods</p> <p>The LPS-stimulated RAW 264.7 macrophages were used to evaluate the effect of RIAA on the NF-κB and MAPK signaling pathways; phosphorylation of ERK1/2, p38 and JNK was assessed by western blotting and NF-κB binding by electrophoretic mobility shift assays. Effect on the NF-κB activity was evaluated by the luciferase reporter assays in LPS-stimulated RAW 264.7 cells. GSK-3α/β kinase activity was measured in cell-free assays. The inhibitory effect of RIAA on inflammatory markers was assessed by measuring nitric oxide in LPS-stimulated RAW 264.7 cells, RANKL-mediated TRAP activity in transformed osteoclasts, and TNF-α/IL-1β-mediated MMP-13 expression in SW1353 cells. Mice with collagen-induced arthritis were fed with RIAA for 2 weeks. Symptoms of joint swelling, arthritic index and joint damage were assessed.</p> <p>Results</p> <p>RIAA selectively inhibited the NF-κB pathway while having no effect on ERK1/2, p38 and JNK phosphorylation in LPS-stimulated RAW 264.7 cells. RIAA also inhibited GSK-3α/β kinase activity and GSK-3β dependent phosphorylation of β-catenin in RAW 264.7 cells. In addition, RIAA inhibited NF-κB-mediated inflammatory markers in various cell models, including nitric oxide in LPS-stimulated RAW 264.7 cells, RANKL-mediated TRAP activity in transformed osteoclasts, and TNF-α/IL-1β-mediated MMP-13 expression in SW1353 human chondrosarcoma cells. Finally, in a mouse model of collagen-induced arthritis, RIAA ameliorated joint damage as evidenced by significant reduction of the arthritis index and histology score; at 250 mg/kg-body weight, RIAA had efficacy similar to that of 20 mg/kg-body weight of celecoxib.</p> <p>Conclusion</p> <p>RIAA may have potential as an anti-inflammatory therapeutic.</p

Late glacial palaeoclimate investigations at King Arthur’s Cave and Sun Hole Cave.

King Arthur’s Cave (Wye Valley) and Sun Hole Cave (Cheddar Gorge) currently provide the earliest dates for a human presence in the British Isles after the Last Glacial Maximum. The earliest phase of activity at these sites has been dated to c. 15.2 to 14.6 thousand years cal. BP, which spans the onset of the Late Glacial Interstadial, a major global climate transition characterised by rapidly warming temperatures. Here we present stable isotope data from horse (Equus ferus) teeth found in the zooarchaeological assemblages at the sites. We also report two new radiocarbon dates on specimens from King Arthur’s Cave. The Equus tooth enamel provides a record of climatic conditions during the animals’ tooth formation. Evidence of human modification of the teeth (cut marks and fractures) chronologically tie these palaeoclimatic records to the earliest post-LGM archaeology at the two sites, thus informing on the climatic and environmental context under which human activity in these areas took place. Results indicate that people were present at the two sites during a period of climatic warming, with temperatures perhaps only marginally colder than present day conditions. However, suboptimal environmental conditions are suggested and may indicate changing vegetation dynamics within the local landscape

Warm-Hot Gas in and around the Milky Way: Detection and Implications of OVII Absorption toward LMC X-3

X-ray absorption lines of highly-ionized species such as OVII at about zero redshift have been firmly detected in the spectra of several active galactic nuclei. However, the location of the absorbing gas remains a subject of debate. To separate the Galactic and extragalactic contributions to the absorption, we have obtained Chandra LETG-HRC and FUSE observations of the black hole X-ray binary LMC X--3. A joint analysis of the detected OVII and Ne IX Kalpha lines, together with the non-detection of the OVII Kbeta and OVIII Kalpha lines, gives the measurements of the temperature, velocity dispersion, and hot oxygen column density. The X-ray data also allow us to place a 95% confidence lower limit to the Ne/O ratio as 0.14. The OVII line centroid and its relative shift from the Galactic OI Kalpha absorption line, detected in the same observations, are inconsistent with the systemic velocity of LMC X--3 ($+310 {\rm km s^{-1}}$). The far-UV spectrum shows OVI absorption at Galactic velocities, but no OVI absorption is detected at the LMC velocity at $> 3\sigma$ significance. Both the nonthermal broadening and the decreasing scale height with the increasing ionization state further suggest an origin of the highly-ionized gas in a supernova-driven galactic fountain. In addition, we estimate the warm and hot electron column densities from our detected OVII Kalpha line in the LMC X--3 X-ray spectra and from the dispersion measure of a pulsar in the LMC vicinity. We then infer the O/H ratio of the gas to be $\gtrsim 8 \times 10^{-5}$, consistent with the chemically-enriched galactic fountain scenario. We conclude that the Galactic hot interstellar medium should in general substantially contribute to zero-redshift X-ray absorption lines in extragalactic sources.Comment: 11 pages, accepted for publication in Ap

The Deuterium, Oxygen, and Nitrogen Abundance Toward LSE 44

We present measurements of the column densities of interstellar DI, OI, NI, and H2 made with FUSE, and of HI made with IUE toward the sdO star LSE 44, at a distance of 554+/-66 pc. This target is among the seven most distant Galactic sight lines for which these abundance ratios have been measured. The column densities were estimated by profile fitting and curve of growth analyses. We find D/H = (2.24 +1.39 -1.32)E-5, D/O = (1.99 +1.30 -0.67)E-2, D/N = (2.75 +1.19 -0.89)E-1, and O/H = (1.13 +0.96 -0.71)E-3 (2 sigma). Of the most distant Galactic sight lines for which the deuterium abundance has been measured LSE 44 is one of the few with D/H higher than the Local Bubble value, but D/O toward all these targets is below the Local Bubble value and more uniform than the D/H distribution. (Abstract abridged.)Comment: 20 pages, including 9 figures. Accepted for publication in Ap