Neuropharmacological aspects of cognitive neurorehabilitation in epilepsy.

The role of CNS neuromodulators in cognitive neurorehabilitation can be related to two main issues: 1) the negative impact on cognition of drug categories prescribed for different neurologic symptoms, such as spasticity, extrapyramidal symptoms, or epileptic seizures; 2) their possible role in neuroprotection and amelioration of the cognitive status of the patient, especially attention and memory. This paper reviews different pharmacological aspects of cognitive neurorehabilitation in epilepsy

Performance Analysis of Hybrid and Full Electrical Vehicles Equipped with Continuously Variable Transmissions

The main aim of this paper is to study the potential impacts in hybrid and full electrical vehicles performance by utilising continuously variable transmissions. This is achieved by two stages. First, for Electrical Vehicles (EVs), modelling and analysing the powertrain of a generic electric vehicle is developed using Matlab/Simulink-QSS Toolkit, with and without a transmission system of varying levels of complexity. Predicted results are compared for a typical electrical vehicle in three cases: without a gearbox, with a Continuously Variable Transmission (CVT), and with a conventional stepped gearbox. Second, for Hybrid Electrical Vehicles (HEVs), a twin epicyclic power split transmission model is used. Computer programmes for the analysis of epicyclic transmission based on a matrix method are developed and used. Two vehicle models are built-up; namely: traditional ICE vehicle, and HEV with a twin epicyclic gearbox. Predictions for both stages are made over the New European Driving Cycle (NEDC).The simulations show that the twin epicyclic offers substantial improvements of reduction in energy consumption in HEVs. The results also show that it is possible to improve overall performance and energy consumption levels using a continuously variable ratio gearbox in EVs

Stellar abundances and molecular hydrogen in high-redshift galaxies -the far-ultraviolet view

FUSE spectra of star-forming regions in nearby galaxies are compared to composite spectra of Lyman-break galaxies (LBGs), binned by strength of Lyman alpha emission and by mid-UV luminosity. Several far-UV spectral features, including lines dominated by stellar wind and by photospheric components, are very sensitive to stellar abundances. Their measurement in Lyman-break galaxies is compromised by the strong interstellar absorption features, allowing in some cases only upper limits. The derived C and N abundances in the LBGs are no higher than half solar (scaled to oxygen abundance for comparison with emission-line analyses), independent of the strength of Lyman alpha emission. P V absorption indicates abundances as low as 0.1 solar, with an upper limit near 0.4 solar in the reddest and weakest-emission galaxies. Unresolved interstellar absorption components would further lower the derived abundances. Trends of line strength, and derived abundances, are stronger with mid-UV luminosity than with Lyman-alpha strength. H2 absorption in the Lyman and Werner bands is very weak in the LBGs. Template H2 absorption spectra convolved to appropriate resolution show that strict upper limits N(H2)< 10^18 cm^-2 apply in all cases, with more stringent values appropriate for the stronger-emission composites and for mixes of H2 level populations like those on Milky Way sight lines. Since the UV-bright regions are likely to be widespread in these galaxies, these results rule out massive diffuse reservoirs of H2, and suggest that the dust/gas ratio is already fairly large at z~3.Comment: Astron J., in press (June 2006

General models of Einstein gravity with a non-Newtonian weak-field limit

We investigate Einstein theories of gravity, coupled to a scalar field \vphi and point-like matter, which are characterized by a scalar field-dependent matter coupling function e^{H(\vphi)}. We show that under mild constraints on the form of the potential for the scalar field, there are a broad class of Einstein-like gravity models -characterized by the asymptotic behavior of H- which allow for a non-Newtonian weak-field limit with the gravitational potential behaving for large distances as ln r. The Newtonian term GM/r appears only as sub-leading. We point out that this behavior is also shared by gravity models described by f(R) Lagrangians. The relevance of our results for the building of infrared modified theories of gravity and for modified Newtonian dynamics is also discussed.Comment: 9 page

Transcriptome Analysis of CD4+ T Cells in Coeliac Disease Reveals Imprint of BACH2 and IFNγ Regulation

peer-reviewedData Availability: The raw sequencing reads (FASTQ files) and sequence read counts mapped to UCSC hg19 for each of the 74 transcriptomes sequenced in this study have been deposited at Gene Expression Omnibus (GEO) accession GSE69549.This project was funded by Science Foundation Ireland Grant number 09/IN.1/B2640 to RM.Genetic studies have to date identified 43 genome wide significant coeliac disease susceptibility (CD) loci comprising over 70 candidate genes. However, how altered regulation of such disease associated genes contributes to CD pathogenesis remains to be elucidated. Recently there has been considerable emphasis on characterising cell type specific and stimulus dependent genetic variants. Therefore in this study we used RNA sequencing to profile over 70 transcriptomes of CD4+ T cells, a cell type crucial for CD pathogenesis, in both stimulated and resting samples from individuals with CD and unaffected controls. We identified extensive transcriptional changes across all conditions, with the previously established CD gene IFNy the most strongly up-regulated gene (log2 fold change 4.6; Padjusted = 2.40x10-11) in CD4+ T cells from CD patients compared to controls. We show a significant correlation of differentially expressed genes with genetic studies of the disease to date (Padjusted = 0.002), and 21 CD candidate susceptibility genes are differentially expressed under one or more of the conditions used in this study. Pathway analysis revealed significant enrichment of immune related processes. Co-expression network analysis identified several modules of coordinately expressed CD genes. Two modules were particularly highly enriched for differentially expressed genes (P</iframe

Preliminary report on IUE spectra of the Crab Nebula

The Crab Nebula is marginally observable with the IUE. Observations of the optically brightest filamentary regions, made with IUE in August 1979, show the C IV lambda 1549, He II lambda 1640, and C III lambda 1909 emission lines. The intensities of these lines were compared with the visual wavelength data. It appears that carbon is not overabundant in the Crab; carbon/oxygen is approximately normal and oxygen is slightly scarcer than normal as a fraction of the total mass

Tempted to Text: College Students’ Mobile Phone Use During a Face-to-Face Interaction With a Close Friend

We examined whether emerging adults would engage in mobile phone use (MPU) when given the opportunity to socialize face-to-face with a close friend in a laboratory setting. Sixty-three U.S. college student friendship dyads rated their friendship quality in an online survey before coming into the laboratory together. When they arrived for their appointment, they were asked to wait together in a room for 5 min. A hidden camera recorded each dyad. Friends then separately rated the quality of the interaction. We coded time spent using mobile phone in seconds. A hierarchical regression conducted at the level of the dyad controlling for friendship quality and gender showed that more MPU was associated with lower quality interactions. We discuss findings in terms of the potential for MPU to interfere with the development of friendship intimacy

Temporal Variability of the X-ray Emission of the Crab Nebula Torus

We have analyzed five ROSAT HRI images of the Crab Nebula spanning the years 1991 to 1997 and have found significant changes in the emission structure of the X-ray torus surrounding the pulsar. Certain regions increase in brightness by about 20% over the six years, while others show decreases in surface brightness. The origin of these changes is unclear, but a possible explanation is that the bulk velocity of the synchrotron radiating electrons has decreased on the order of 20% as well.Comment: 15 pages plus 6 figures, figure 1 and figure 6 are in color, to appear in The Astrophysical Journal, Jan 1, 1999, Vol. 510, #