Ending cervical cancer: A call to action.

The outlook for elimination of the scourge of cervical cancer is bright, because we now have the tools to achieve this goal. In recent years human papillomavirus (HPV) vaccination in high-income countries has resulted in dramatic decreases in HPV infection and associated cervical disease. If all countries with a substantial burden of disease introduce the vaccine nationally, we can protect the vast majority of women and girls most at risk. For women who are beyond the vaccination target age, progress has been made in screening and treatment for cervical precancer, but we must accelerate this momentum to reduce incidence and mortality worldwide to the very low rates found in wealthier countries. Human and financial resources must be increased and directed to programs that follow best practices and reach all women, including the marginalized or disadvantaged. Seven key actions are recommended. Now is the time for action at national, regional, and global levels

Nuclear Shell Model Calculations of Neutralino-Nucleus Cross Sections for Silicon 29 and Germanium 73

We present the results of detailed nuclear shell model calculations of the spin-dependent elastic cross section for neutralinos scattering from \si29 and \ge73. The calculations were performed in large model spaces which adequately describe the configuration mixing in these two nuclei. As tests of the computed nuclear wave functions, we have calculated several nuclear observables and compared them with the measured values and found good agreement. In the limit of zero momentum transfer, we find scattering matrix elements in agreement with previous estimates for \si29 but significantly different than previous work for \ge73. A modest quenching, in accord with shell model studies of other heavy nuclei, has been included to bring agreement between the measured and calculated values of the magnetic moment for \ge73. Even with this quenching, the calculated scattering rate is roughly a factor of 2 higher than the best previous estimates; without quenching, the rate is a factor of 4 higher. This implies a higher sensitivity for germanium dark matter detectors. We also investigate the role of finite momentum transfer upon the scattering response for both nuclei and find that this can significantly change the expected rates. We close with a brief discussion of the effects of some of the non-nuclear uncertainties upon the matrix elements.Comment: 31 pages, figures avaiable on request, UCRL-JC-11408

Pirates of the Caribbean : dead man's chest : Level 3 : Base on the screenplay written by Ted Elliott and Terry Rossio

58 p. : col. ill. ; 20 cm

MERBoard User's Guide

An important goal of MERBoard is to allow users to quickly and easily share information. The front-end interface is physically a large plasma computer display with a touch screen, allowing multiple people to interact shoulder-to-shoulder or in a small meeting area. The software system allows people to interactively create digital whiteboards, browse the web, give presentations and connect to personal computers (for example, to run applications not on the MERBoard computer itself). There are four major integrated applications: a browser; a remote connection to another computer (VNC); a digital whiteboard; and a digital space (MERSpace), which is a digital repository for each individual user

Scattering of weakly interacting massive particles from Ge

We use a "hybrid" method, mixing variationally-determined triaxial nuclear Slater determinants, to calculate the response of Ge73 to hypothetical dark-matter particles such as neutralinos. The method is a hybrid in that rotational invariance is approximately restored prior to variation and then fully restored before the mixing of intrinsic states. We discuss such features of Ge73 as shape coexistence and triaxiality, and their effects on spin-dependent neutralino cross sections. Our calculations yield a satisfactory quadrupole moment and an accurate magnetic moment in this very complicated nucleus, suggesting that the spin structure and thus the axial--vector response to dark matter particles is modeled well.Comment: 8 pages in RevTeX 3 plus 2 uuencoded figures, submitted to Phys. Rev.

Reducing Uncertainties About the Effects of Chemoradiotherapy for Cervical Cancer: A Systematic Review and Meta-Analysis of Individual Patient Data From 18 Randomized Trials

Background After a 1999 National Cancer Institute (NCI) clinical alert was issued, chemoradiotherapy has become widely used in treating women with cervical cancer. Two subsequent systematic reviews found that interpretation of the benefits was complicated, and some important clinical questions were unanswered. Patients and Methods We initiated a meta-analysis seeking updated individual patient data from all randomized trials to assess the effect of chemoradiotherapy on all outcomes. We prespecified analyses to investigate whether the effect of chemoradiotherapy differed by trial or patient characteristics. Results On the basis of 13 trials that compared chemoradiotherapy versus the same radiotherapy, there was a 6% improvement in 5-year survival with chemoradiotherapy (hazard ratio [HR] = 0.81, P <.001). A larger survival benefit was seen for the two trials in which chemotherapy was administered after chemoradiotherapy. There was a significant survival benefit for both the group of trials that used platinum-based (HR = 0.83, P = .017) and non-platinum-based (HR = 0.77, P <.009) chemoradiotherapy, but no evidence of a difference in the size of the benefit by radiotherapy or chemotherapy dose or scheduling was seen. Chemoradiotherapy also reduced local and distant recurrence and progression and improved disease-free survival. There was a suggestion of a difference in the size of the survival benefit with tumor stage, but not across other patient subgroups. Acute hematologic and GI toxicity was increased with chemoradiotherapy, but data were too sparse for an analysis of late toxicity. Conclusion These results endorse the recommendations of the NCI alert, but also demonstrate their applicability to all women and a benefit of non-platinum-based chemoradiotherapy. Furthermore, although these results suggest an additional benefit from adjuvant chemotherapy, this requires testing in randomized trials

Ohjaustyylin valinta: ulkoa- vai sisältäpäin? : Näyttelijäohjauksen keinot sketsiviihteessä

Pohdin opinnäytetyössäni kahta ohjaustyyliä: ulkoa- ja sisältäpäin. Käsittelen aihetta sketsiviihteen maailmassa ja sieltä nousevien hahmotyyppien avulla: karikatyyrin rinnastan fyysiikkaan ja realistislähtöisen hahmon ajatuksiin. Lopussa käsittelen mediaosuutena tekemääni lopputyötä sketsisarjan pilottijakso Sirkkeliä, sen hahmoja, ohjausharjoituksia ja kuvauksia sekä esittelen Kaverimetodiksi nimeämäni ohjauksellisen työtavan.I discuss about two ways of directing actors in comedy: outside-in and inside-out. I'm using comedy genre as a frame for the subject. From the world of comedy I will bring two types of charachters: caricature and realism based charachter. Caricature links with physics and realism based character with thoughts. In the end I will write about my thesis work Sirkkeli as it is a pilot for comedy series. I will explain how its characters, actor trainings and the shootings worked out

13th National Congress of the South African Society of Psychiatrists, 20-23 September 2004

List of abstacts and authors: 1. Integrating the art and science of psychiatry Eugene Allers 2. Chronic pain as a predictor of outcome in an inpatient Psychiatric population Eugene Allers and Gerhard Grundling 3. Recent advances in social phobia Christer Allgulander 4. Clinical management of patients with anxiety disorders Christer Allgulander 5. Do elephants suffer from Schizophrenia? (Or do the Schizophrenias represent a disorder of self consciousness?) A Southern African perspective Sean Exner Baumann 6. Long term maintenance treatment of Bipolar Disorder: Preventing relapse Charles L. Bowden 7. Predictors of response to treatments for Bipolar Disorder Charles L. Bowden 8. Aids/HIV knowledge and high risk behaviour: A Geo-graphical comparison in a schizophrenia population P Buckley, S van Vuuren, L Koen, J E Muller, C Seller, H Lategan, D J H Niehaus 9. Does Marijuana make you go mad? David J Castle 10. Understanding and management of Treatment Resistant Schizophrenia David J Castle 11. Workshop on research and publishing David J Castle 12. From victim to victor: Without a self-help book Beatrix Jacqueline Coetzee 13. The evaluation of the Gender Dysphoric patient Franco Colin 14. Dissociation: A South African model A M Dikobe, C K Mataboge, L M Motlana, B F Sokudela, C Kruger 15. Designated smoking rooms...and other "Secret sins" of psychiatry: Tobacco cessation approaches in the severely mentally ill Charl Els 16. Dual diagnosis: Implications for treatment and prognosis Charl Els 17. Body weight, glucose metabolism and the new generation antipsychotics Robin Emsley 18. Neurological abnormalities in first episode Schizophrenia: Temporal stability and clinical and outcome correlates Robin Emsley, H Jadri Turner, Piet P Oosthuizen, Jonathan Carr 19. Mythology of depressive illnesses among Africans Senathi Fisha 20. Substance use and High school dropout Alan J. Flisher, Lorraine Townsend, Perpetual Chikobvu, Carl Lombard, Gary King 21. Psychosis and Psychotic disorders A E Gangat 22. Vulnerability of individuals in a family system to develop a psychiatric disorder Gerhard Grundling and Eugene Allers 23. What does it Uberhaupt mean to "Integrate"? Jürgen Harms 24. Research issues in South African child and adolescent psychiatry S M Hawkridge 25. New religious movements and psychiatry: The Good News V H Hitzeroth 26. The pregnant heroin addict: Integrating theory and practice in the development and provision of a service for this client group V H Hitzeroth, L Kramer 27. Autism spectrum disorder Erick Hollander 28. Recent advances and management in treatment resistance Eric Hollander 29. Bipolar mixed states M. Leigh Janet 30. Profile of acute psychiatric inpatients tested for HIV - Helen Jospeh Hospital, Johannesburg A B R Janse van Rensburg 31. ADHD - Using the art of film-making as an education medium Shabeer Ahmed Jeeva 32. Treatment of adult ADHD co-morbidities Shabeer Ahmed Jeeva 33. Needs and services at ward one, Valkenberg Hospital Dr J. A. Joska, Prof. A.J. Flisher 34. Unanswered questions in the adequate treatment of depression Moderator: Dr Andre F Joubert Expert: Prof. Tony Hale 35. Unanswered questions in treatment resistant depression Moderator: Dr Andre F Joubert Expert: Prof. Sidney Kennedy 36. Are mentally ill people dangerous? Sen Z Kaliski 37. The child custody circus Sean Z. Kaliski 38. The appropriatenes of certification of patients to psychiatric hospitals V. N. Khanyile 39. HIV/Aids Psychosocial responses and ethical dilemmas Fred Kigozi 40. Sex and Psychiatry B Levinson 41. Violence and abuse in psychiatric in-patient institutions: A South African perspective Marilyn Lucas, John Weinkoove, Dean Stevenson 42. Public health sector expenditure for mental health - A baseline study for South Africa E N Madela-Mntla 43. HIV in South Africa: Depression and CD4 count M Y H Moosa, F Y Jeenah 44. Clinical strategies in dealing with treatment resistant schizophrenia Piet Oosthuizen, Dana Niehaus, Liezl Koen 45. Buprenorphine/Naloxone maintenance in office practice: 18 months and 170 patients after the American release Ted Parran Jr, Chris Adelman 46. Integration of Pharmacotherapy for Opioid dependence into general psychiatric practice: Naltrexone, Methadone and Buprenorphine/ Naloxone Ted Parran 47. Our African understanding of individulalism and communitarianism Willie Pienaar 48. Healthy ageing and the prevention of Dementia Felix Potocnik, Susan van Rensburg, Christianne Bouwens 49. Indigenous plants and methods used by traditional African healers for treatinf psychiatric patients in the Soutpansberg Area (Research was done in 1998) Ramovha Muvhango Rachel 50. Symptom pattern & associated psychiatric disorders in subjects with possible & confirmed 22Q11 deletional syndrome J.L. Roos, H.W. Pretorius, M. Karayiorgou 51. Duration of antidepressant treatment: How long is long enough? How long is too long Steven P Roose 52. A comparison study of early non-psychotic deviant behaviour in the first ten years of life, in Afrikaner patients with Schizophrenia, Schizo-affective disorder and Bipolar disorder Martin Scholtz, Melissa Janse van Rensburg, J. Louw Roos 53. Treatment, treatment issues, and prevention of PTSD in women: An update Soraya Seedat 54. Fron neural networks to clinical practice M Spitzer 55. Opening keynote presentation: The art and science of Psychiatry M Spitzer 56. The future of Pharmacotherapy for anxiety disorders Dan J. Stein 57. Neuropsychological deficits pre and post Electro Convulsive Therapy (ECT) thrice a week: A report of four cases Ugash Subramaney, Yusuf Moosa 58. Prevalence of and risk factors for Tradive Dyskinesia in a Xhosa population in the Eastern Cape Dave Singler, Betty D. Patterson, Sandi Willows 59. Eating disorders: Addictive disorders? Christopher Paul Szabo 60. Ethical challenges and dilemmas of research in third world countries Godfrey B. Tangwa 61. The interface between Neurology and Psychiatry with specific focus on Somatoform dissociative disorders Michael Trimble 62. Prevalence and correlates of depression and anxiety in doctors and teachers H Van der Bijl, P Oosthuizen 63. Ingrid Jonker: A psychological analysis L. M. van der Merwe 64. The strange world we live in, and the nature of the human subject Vasi van Deventer 65. Art in psychiatry: Appendix or brain stem? C W van Staden 66. Medical students on what "Soft skills" are about before and after curriculum reform C W van Staden, P M Joubert, A-M Bergh, G E Pickworth, W J Schurink, R R du Preez, J L Roos, C Kruger, S V Grey, B G Lindeque 67. Attention deficit hyperactivity disorder (ADHD) - Medical management. Methylphenidate (Ritalin) or Atomoxetine (Strattera) Andre Venter 68. A comprehensive guide to the treatment of adults with ADHD W J C Verbeeck 69. Treatment of Insomnia: Stasis of the Art? G C Verster 70. Are prisoners vulnerable research participants? Merryll Vorster 71. Psychiatric disorders in the gym Merryl Vorster 72. Ciprales: Effects on anxiety symptoms in Major Depressive Disorder Bruce Lydiar