Coût du défaut de transfert d’immunité passive chez le veau et économie des stratégies préventives associées

Chez les bovins, la protection immunitaire des nouveau-nés est très dépendante de l’ingestion de colostrum. Un défaut de transfert d’immunité passive (TIP) lié à une mauvaise ingestion de colostrum est associé à des risques accrus de mortalité et morbidité. L’objectif ici est (i) de quantifier le coût d’un défaut de TIP, d’évaluer (ii) les ressources à allouer à la distribution colostrale et (iii) l’intérêt financier à vacciner contre les diarrhées du nouveau-né. Différents scénarios sont proposés. Le coût d’un défaut de TIP dans le scénario le plus plausible est de 80€ [20-139] et 60€ [11-109] par veaux avec défaut de TIP, respectivement en élevage allaitant et laitier. La distribution du colostrum s’avèrerait rentable dans la quasi-totalité des cas, y compris pour des coûts horaires très élevés. En revanche, la rentabilité d’une vaccination des mères nécessite d’être discutée en fonction de l’efficacité du vaccin d’une part et de la prévalence de défaut de TIP d’autre part

Influence of breed on reactivity of sheep to humans

International audienc

Modified Elmslie-Trillat procedure for distal realignment of patella tendon

Patellofemoral dysfunction, due to either a patellofemoral malalignment or patellar instability, is a complex and debilitating condition that significantly decreases the knee function. Conservative management may yield significant clinical outcomes; however, when morphologic anomalies are identified, the surgical approach should be employed. Hence, several surgical procedures have been described in the scientific literature aiming the correction of underlying extensor mechanism malalignments. Still, the rate of complications is higher than desirable. The described technique is based on the principles of transferring the tibial tubercle medially as described in the Elmslie-Trillat technique. However, a curvilinear horizontal cut is made prior to the vertical cut, which raises a thick osseous fragment and allows the formation of a gutter when the osseous fragment is moved medially. Whereas the horizontal gutter provides stability to the bone fragment, the thicker dimension of the osseous fragment and retention of the distal attachment significantly enhances the osteotomy union. Hence, adequate pain relief and stability with very low postoperative morbidity could be achieved. The purpose of this surgical note is to describe a modification to the Elmslie-Trillat technique to treat patellofemoral dysfunctions, achieving a higher osseous stability and decreased postoperative morbidity.info:eu-repo/semantics/publishedVersio

An extensive phenotypic characterization of the hTNFα transgenic mice

<p>Abstract</p> <p>Background</p> <p>Tumor necrosis factor alpha (TNFα) is implicated in a wide variety of pathological and physiological processes, including chronic inflammatory conditions, coronary artery disease, diabetes, obesity, and cachexia. Transgenic mice expressing human TNFα (hTNFα) have previously been described as a model for progressive rheumatoid arthritis. In this report, we describe extensive characterization of an hTNFα transgenic mouse line.</p> <p>Results</p> <p>In addition to arthritis, these hTNFα transgenic mice demonstrated major alterations in body composition, metabolic rate, leptin levels, response to a high-fat diet, bone mineral density and content, impaired fertility and male sexual function. Many phenotypes displayed an earlier onset and a higher degree of severity in males, pointing towards a significant degree of sexual dimorphism in response to deregulated expression of TNFα.</p> <p>Conclusion</p> <p>These results highlight the potential usefulness of this transgenic model as a resource for studying the progressive effects of constitutively expressed low levels of circulating TNFα, a condition mimicking that observed in a number of human pathological conditions.</p

A 10 year follow-up study after Roux-Elmslie-Trillat treatment for cases of patellar instability

<p>Abstract</p> <p>Background</p> <p>A retrospective study concerning patients presenting with patella instability, treated using a Roux-Elmslie-Trillat reconstruction operation and followed up for 10 years following surgery, is presented.</p> <p>Methods</p> <p>Pre-operative and follow-up radiographic evaluation included the weight-bearing anteroposterior and merchant views. Evaluation was carried out using the Insall-Salvati index, sulcus and congruence angle. The Roux-Elmslie-Trillat reconstruction operation was performed on 18 patients. The clinical evaluation at follow-up was performed using the Knee-Society-Score (KSS) and Tegner-Score.</p> <p>Results</p> <p>Subjective results of the operation were classed as excellent or good in 16 of the 18 patients ten years after surgery; persistent instability of the patella was recorded in only one of the 18 patients. The majority of patients returned to the same level of sporting activity after surgery as they had participated in before injury.</p> <p>Conclusions</p> <p>The Roux-Elmslie-Trillat procedure could be recommended in cases presenting with an increased q-angle, trochlea dysplasia or failed soft tissue surgery. In the present study the majority of patients report a return to previous sporting activity ten years after surgery.</p