APPROACHES AND METHODS OF INTERNAL AUDIT OF THE EDUCATIONAL ORGANIZATION

Раскрыта сущность применения процессного подхода в управлении образовательной организацией, неотъемлемой частью которого является внутренний аудит. Раскрыты способы проведения аудита: аудит сквозных процессов и аудит подразделений. Показаны преимущества и недостатки каждого из рассматриваемых подходовThe essence of application of process approach in management of the educational organization which integral part is internal audit is revealed. The methods of audit are disclosed: audit of end-to-end processes and audit of departments. The advantages and disadvantages of each of the approaches are show

TRENDS IN THE DEVELOPMENT AND MANAGEMENT OF SYSTEMS OF CONTINUOUS EDUCATION OF ADULTS

Представлены результаты анализа и актуализации потенциала непрерывного образования взрослых в современных условиях. Дается обоснование постановки вопроса об управлении системами непрерывного образования взрослых, с акцентом на вопросы ее регионализации. Показываются единые тенденции в реформировании мировых систем образования взрослыхThe results of the analysis and actualization of the potential of continuous adult education in modern conditions are presented. The substantiation of the question of management of systems of continuous education of adults, with an emphasis on the issues of its regionalization. Seems a common trend in the reform of global systems of adult educatio

Agrobiological evaluation of Allium ampeloprasum L. variety samples in comparison with Allium sativum L. cultivars

ArticleThe purpose of investigation is to study the biological and morphological features, to establish the economic and valuable characteristics of the introduced and local forms of Allium ampeloprasum L. in comparison with Allium sativum L. and to study the effect of removal of the scape in the yield. The studies used field, statistical, settlement and analytical methods. The weight of the bulb without removing the inflorescence shoot of the cultivar Sofiivskyi was 28.4– 53.3 g smaller than the variety samples No. 2 and No. 3 respectively. With removing the scape the difference increased by 60.5–68.6 g. The yield of No. 2 variety sample Allium ampeloprasum L. without removing the scape was lower than the standard by 1.7 t ha-1 while the variety sample No. 3 exceeded the standard by 1.1 t ha-1 . With the removal of inflorescence shoot the yields of variety samples No. 2 and No. 3 exceeded the cultivar Sofiivskyi by 1.6 and 2.2 t ha-1 . It has been established according to the researches that introduced forms of Allium ampeloprasum L. have high indicators of economic and valuable characteristics, but they are limited in the first years of cultivation, by the period of adaptation to the new soil and climatic conditions

Agrobiological assessment of productivity and nitrogen fixation of vegetable soybean (edamame) in the conditions of Forest-Steppe of Ukraine

Received: May 25th, 2023 ; Accepted: October 18th, 2023 ; Published: October 30th, 2023 ; Correspondence: [email protected] evaluation of vegetable soybean cultivars (Glycine max var. Shirofumi) according to a complex of economically valuable traits for introduction in the conditions of the Forest-Steppe of Ukraine it was carried out with the aim of selecting the source material and selecting promising breeding forms according to morpho-biological and physiologicalbiochemical characteristics. The research was conducted in the conditions of the educational and production department of Uman National University of Horticulture during 2020–2022, collection cultivars of different ecological and geographical origins were used. The cultivars ‘Sac’ (166.00 g plant-1 ), ‘Vesta’ (139.33 g plant-1 ), ‘Fiskeby V’ (133.33 g plant-1 ), and ‘Fiskeby V-E5’ (146.67 g plant-1 ) possessed a large mass of edamame beans. The maximum yield of edamame beans was formed by plants of the ‘L 380-2-13’ (12.67 t ha-1 ), ‘Vesta’ (12.33 t ha-1 ), ‘Sac’ (13.20 t ha-1 ), ‘Fiskeby V’ (13.97 t ha-1 ), and ‘Fiskeby V-E5’ (14.53 t ha-1 ). Weather conditions during the period of research significantly influenced the yield and biochemical composition of edamame varieties. The yield of edamame beans ranged from 5.40 t ha-1 in 2020 (min) to 22.40 t ha-1 in 2021 (max), and the coefficient of variation by varieties was at the level of 19–41%. This phenomenon is explained by the minimum amount of precipitation in 2020 and the high amount in 2021, which is confirmed by the hydrothermal coefficient during the period of intensive pod growth (VII–VIII) - 2020 - 0.3; 2021 - 1.3 and 1.1 respectively for the month. The protein concentration in Edamame beans was in the range of 27.94–36.29%. A higher protein content relative to the standard was noted in one sample - ‘Karikachi’ - 36.29%. Minimal accumulation of oligosaccharides was noted in ‘Sac’ and ‘Astra’ cultivars, which indicates their suitability for consumption. Promising cultivars were identified by the amount of fixed nitrogen - ‘Sac’ (168.00 ± 4.32 kg ha-1 ), ‘Astra’ (161.67 ± 2.36 kg ha-1 ) and SybNYYSOH 6 (158.19 ± 4.56 kg ha-1 ). The conducted regression analysis showed close relationships (from moderate to functional) between various indicators of the development and productivity of the nodulation apparatus of edamame cultivars. The evaluation of the collection cultivars of vegetable soybeans, their use according to the variability of morphological features and productivity made it possible to single out the ‘Sac’ among the introduced collection cultivars based on a set of valuable traits for use in the selection process to create new cultivars of vegetable soybeans

Designing of rational structure of range of insulating protective clothing on the basis of the principles of transformation

The aim of this work is to develop a range structure of insulating change of clothes with predictable characteristics for the employees of nuclear power plants (NPP). It was applied a systematic approach to solve the assigned tasks, which made it possible to use the principles of transformation through the gradual changes in design and complete of protective clothing. The implementation of the assigned tasks was carried out using the method of structural optimization of construction of insulating protective clothing. The rational structure of range of insulating change of clothes with predictable coefficient of protection, weight and cost was formed on the basis of the principles of transformation by the method of structural optimization. It was obtained the formula for calculation of protection coefficient under constraints on weight, cost, number of material layers (taking into consideration the non-linearity of the objective function), under constraints and discretization of initial information for the packages of protective clothing. Structural and logical matrix for insulating change of protective clothing was formed. There were proposed a structure of insulating change of clothing for NPP employees, structural and technological solutions for the products from the product range. Task-oriented selection of modules and methods of their transformation within the designed object was carried out

Fashion design in a multicultural space

The collective monograph contains the results of the synthesis of theoretical materials, as well as the authors` applied research developments on the design of the clothes of different assortment and purpose, made from different materials considering the modern scientific methods

Downstream signalling and specific inhibition of c-MET/HGF pathway in small cell lung cancer: implications for tumour invasion

The c-MET receptor can be overexpressed, amplified, or mutated in solid tumours including small cell lung cancer (SCLC). In c-MET-overexpressing SCLC cell line NCI-H69, hepatocyte growth factor (HGF) dramatically induced c-MET phosphorylation at phosphoepitopes pY1230/1234/1235 (catalytic tyrosine kinase), pY1003 (juxtamembrane), and also of paxillin at pY31 (CRKL-binding site). We utilised a global proteomics phosphoantibody array approach to identify further c-MET/HGF signal transduction intermediates in SCLC. Strong HGF induction of specific phosphorylation sites in phosphoproteins involved in c-MET/HGF signal transduction was detected, namely adducin-α [S724], adducin-γ [S662], CREB [S133], ERK1 [T185/Y187], ERK1/2 [T202/Y204], ERK2 [T185/Y187], MAPKK (MEK) 1/2 [S221/S225], MAPKK (MEK) 3/6 [S189/S207], RB [S612], RB1 [S780], JNK [T183/Y185], STAT3 [S727], focal adhesion kinase (FAK) [Y576/S722/S910], p38α-MAPK [T180/Y182], and AKT1[S473] and [T308]. Conversely, inhibition of phosphorylation by HGF in protein kinase C (PKC), protein kinase R (PKR), and also CDK1 was identified. Phosphoantibody-based immunohistochemical analysis of SCLC tumour tissue and microarray established the role of c-MET in SCLC biology. This supports a role of c-MET activation in tumour invasive front in the tumour progression and invasion involving FAK and AKT downstream. The c-MET serves as an attractive therapeutic target in SCLC, as shown through small interfering RNA (siRNA) and selective prototype c-MET inhibitor SU11274, inhibiting the phosphorylation of c-MET itself and its downstream molecules such as AKT, S6 kinase, and ERK1/2. Investigation of mechanisms of invasion and, ultimately, metastasis in SCLC would be very useful with these signal transduction molecules

The glial growth factors deficiency and synaptic destabilization hypothesis of schizophrenia

BACKGROUND: A systems approach to understanding the etiology of schizophrenia requires a theory which is able to integrate genetic as well as neurodevelopmental factors. PRESENTATION OF THE HYPOTHESIS: Based on a co-localization of loci approach and a large amount of circumstantial evidence, we here propose that a functional deficiency of glial growth factors and of growth factors produced by glial cells are among the distal causes in the genotype-to-phenotype chain leading to the development of schizophrenia. These factors include neuregulin, insulin-like growth factor I, insulin, epidermal growth factor, neurotrophic growth factors, erbB receptors, phosphatidylinositol-3 kinase, growth arrest specific genes, neuritin, tumor necrosis factor alpha, glutamate, NMDA and cholinergic receptors. A genetically and epigenetically determined low baseline of glial growth factor signaling and synaptic strength is expected to increase the vulnerability for additional reductions (e.g., by viruses such as HHV-6 and JC virus infecting glial cells). This should lead to a weakening of the positive feedback loop between the presynaptic neuron and its targets, and below a certain threshold to synaptic destabilization and schizophrenia. TESTING THE HYPOTHESIS: Supported by informed conjectures and empirical facts, the hypothesis makes an attractive case for a large number of further investigations. IMPLICATIONS OF THE HYPOTHESIS: The hypothesis suggests glial cells as the locus of the genes-environment interactions in schizophrenia, with glial asthenia as an important factor for the genetic liability to the disorder, and an increase of prolactin and/or insulin as possible working mechanisms of traditional and atypical neuroleptic treatments

Cancer Biomarker Discovery: The Entropic Hallmark

Background: It is a commonly accepted belief that cancer cells modify their transcriptional state during the progression of the disease. We propose that the progression of cancer cells towards malignant phenotypes can be efficiently tracked using high-throughput technologies that follow the gradual changes observed in the gene expression profiles by employing Shannon's mathematical theory of communication. Methods based on Information Theory can then quantify the divergence of cancer cells' transcriptional profiles from those of normally appearing cells of the originating tissues. The relevance of the proposed methods can be evaluated using microarray datasets available in the public domain but the method is in principle applicable to other high-throughput methods. Methodology/Principal Findings: Using melanoma and prostate cancer datasets we illustrate how it is possible to employ Shannon Entropy and the Jensen-Shannon divergence to trace the transcriptional changes progression of the disease. We establish how the variations of these two measures correlate with established biomarkers of cancer progression. The Information Theory measures allow us to identify novel biomarkers for both progressive and relatively more sudden transcriptional changes leading to malignant phenotypes. At the same time, the methodology was able to validate a large number of genes and processes that seem to be implicated in the progression of melanoma and prostate cancer. Conclusions/Significance: We thus present a quantitative guiding rule, a new unifying hallmark of cancer: the cancer cell's transcriptome changes lead to measurable observed transitions of Normalized Shannon Entropy values (as measured by high-throughput technologies). At the same time, tumor cells increment their divergence from the normal tissue profile increasing their disorder via creation of states that we might not directly measure. This unifying hallmark allows, via the the Jensen-Shannon divergence, to identify the arrow of time of the processes from the gene expression profiles, and helps to map the phenotypical and molecular hallmarks of specific cancer subtypes. The deep mathematical basis of the approach allows us to suggest that this principle is, hopefully, of general applicability for other diseases

Statistical Measures of the Competition in the Banking System

The article describes the main statistical measures characterizing the key indicators of the competition level of the Russian banking system subjects countrywide and in the regional context. Utilizing common statistical tools of economic significance assessment of financial institutions, a dynamic analysis of banking competition level concentration was held. Dynamics of the main indicators, characterizing the saturation with financial and banking services of the Russian Federation regions, was assessed with regard to a long downward trend of the number of credit institutions. In order to analyze the availability of banking services in Russian regions, indices of total provision and relative attractiveness were evaluated. Quantitative and qualitative characteristics of level and dynamics of banking concentration were considered in depth, geographically and countrywide, with application of Herfindahl-Hirsehman index. Also, an analysis of concentration level of banking system assets was conducted. For this purpose, clusters of credit organizations distribution were considered depending on the value of their assets and their regional allocation