Caracterização da produção agrícola e dos feirantes da agricultura familiar no Município de São Lourenço do Sul-RS

Caracterizou-se a situação produtiva e socioeconômica de 13 feirantes da praça central de São Lourenço do Sul/RS, o qual é constituído por oito distritos, através da aplicação de questionários. A pesquisa foi desenvolvida de fevereiro a março 2015. A renda média dos feirantes é R$1.363,85 mensais. A feira é o principal canal de comercialização dos produtores da agricultura familiar, onde se comercializa principalmente batata, cebola, feijão, batata doce e abóbora. De acordo com os feirantes, a vantagem de comercializar os produtos na feira é a eliminação do atravessador; entre as desvantagens indicam a falta de infraestrutura do local de comercialização. A produção (54$1,363.85. Open market is the main commercialization channel for family farming´s products, in which the most commercialized products are potato, onion, bean, sweet potato and pumpkin. Traders alleged that the absence of middlemen is an advantage of commercializing in the open market; the lack of infrastructure was assumed as a disadvantage. The majority of production systems (54%) are conventional, which represents a field yet to be explored in the sense of a conversion to organic systems. In the socioeconomic aspect there was observed a bond between producers and consumers. Income obtained by trading in the open market was considered satisfactory.Eje: A3: Economía y AgroecologíaFacultad de Ciencias Agrarias y Forestale

Caracterização da produção agrícola e dos feirantes da agricultura familiar no Município de São Lourenço do Sul-RS

Caracterizou-se a situação produtiva e socioeconômica de 13 feirantes da praça central de São Lourenço do Sul/RS, o qual é constituído por oito distritos, através da aplicação de questionários. A pesquisa foi desenvolvida de fevereiro a março 2015. A renda média dos feirantes é R$1.363,85 mensais. A feira é o principal canal de comercialização dos produtores da agricultura familiar, onde se comercializa principalmente batata, cebola, feijão, batata doce e abóbora. De acordo com os feirantes, a vantagem de comercializar os produtos na feira é a eliminação do atravessador; entre as desvantagens indicam a falta de infraestrutura do local de comercialização. A produção (54$1,363.85. Open market is the main commercialization channel for family farming´s products, in which the most commercialized products are potato, onion, bean, sweet potato and pumpkin. Traders alleged that the absence of middlemen is an advantage of commercializing in the open market; the lack of infrastructure was assumed as a disadvantage. The majority of production systems (54%) are conventional, which represents a field yet to be explored in the sense of a conversion to organic systems. In the socioeconomic aspect there was observed a bond between producers and consumers. Income obtained by trading in the open market was considered satisfactory.Eje: A3: Economía y AgroecologíaFacultad de Ciencias Agrarias y Forestale

Caracterização da produção agrícola e dos feirantes da agricultura familiar no Município de São Lourenço do Sul-RS

Caracterizou-se a situação produtiva e socioeconômica de 13 feirantes da praça central de São Lourenço do Sul/RS, o qual é constituído por oito distritos, através da aplicação de questionários. A pesquisa foi desenvolvida de fevereiro a março 2015. A renda média dos feirantes é R$1.363,85 mensais. A feira é o principal canal de comercialização dos produtores da agricultura familiar, onde se comercializa principalmente batata, cebola, feijão, batata doce e abóbora. De acordo com os feirantes, a vantagem de comercializar os produtos na feira é a eliminação do atravessador; entre as desvantagens indicam a falta de infraestrutura do local de comercialização. A produção (54$1,363.85. Open market is the main commercialization channel for family farming´s products, in which the most commercialized products are potato, onion, bean, sweet potato and pumpkin. Traders alleged that the absence of middlemen is an advantage of commercializing in the open market; the lack of infrastructure was assumed as a disadvantage. The majority of production systems (54%) are conventional, which represents a field yet to be explored in the sense of a conversion to organic systems. In the socioeconomic aspect there was observed a bond between producers and consumers. Income obtained by trading in the open market was considered satisfactory.Eje: A3: Economía y AgroecologíaFacultad de Ciencias Agrarias y Forestale

Indications and Limits of Surgery for Spinal Metastases Derived from Lung Cancer: A Single-Center Experience

Lung cancer is the second most frequently diagnosed cancer in the world, and surgery is an integral part of the treatment for spinal metastases. The aims of this retrospective study were to assess the overall survival of surgically treated patients affected by lung cancer spinal metastases and identify any factors related to a better survival rate. We recruited 56 consecutive patients (34 male and 22 female) surgically treated for metastatic lung cancer in the spine from 2009 to 2019. Surgical indications were based on a previously published and validated flow chart following a multidisciplinary evaluation. We assessed the localization of vertebral metastases, the presence of other bone or visceral metastases, neurological status according to the Frankel score, ambulatory autonomy, and general status, measured with the Karnofsky performance scale. The expected prognosis was retrospectively assessed according to the revised Tokuhashi score. The median survival was 8.1 months, with over a third of patients surviving more than 1 year. We observed a global improvement in all clinical parameters after surgical treatment. The Tokuhashi predictive score did not correlate with survival after surgery. The results of this study suggest that the surgical treatment of symptomatic spinal metastases from lung cancer can improve quality of life, even in patients with a shorter life expectancy, by controlling pain and improving autonomy

Dinâmica de perfilhamento em capim annoni sob crescimento livre.

CONGREGA

Roles for the coactivators CBP and p300 and the APC/C E3 ubiquitin ligase in E1A-dependent cell transformation

Adenovirus early region 1A (E1A) possesses potent transforming activity when expressed in concert with activated ras or E1B genes in in vitro tissue culture systems such as embryonic human retinal neuroepithelial cells or embryonic rodent epithelial and fibroblast cells. Early region 1A has thus been used extensively and very effectively as a tool to determine the molecular mechanisms that underlie the basis of cellular transformation. In this regard, roles for the E1A-binding proteins pRb, p107, p130, cyclic AMP response element-binding protein (CBP)/p300, p400, TRRAP and CtBP in cellular transformation have been established. However, the mechanisms by which E1A promotes transformation through interaction with these partner proteins are not fully delineated. In this review, we focus on recent advances in our understanding of CBP/p300 function, particularly with regard to its relationship to the anaphase-promoting complex/cyclosome E3 ubiquitin ligase, which has recently been shown to interact and affect the activity of CBP/p300 through interaction domains that are evolutionarily conserved in E1A

Elevated lactate dehydrogenase has prognostic relevance in treatment-na\uefve patients affected by chronic lymphocytic leukemia with trisomy 12

Chronic Lymphocytic Leukemia (CLL) patients with +12 have been reported to have specific clinical and biologic features. We performed an analysis of the association between demographic; clinical; laboratory; biologic features and outcome in CLL patients with +12 to identify parameters predictive of disease progression; time to treatment; and survival. The study included 487 treatment-naive CLL patients with +12 from 15 academic centers; diagnosed between January 2000 and July 2016; and 816 treatment-na\uefve patients with absence of Fluorescence In Situ Hybridization (FISH) abnormalities. A cohort of 250 patients with +12 CLL followed at a single US institution was used for external validation. In patients with +12; parameters associated with worse prognosis in the multivariate model were high Lactate DeHydrogenase (LDH) and \u3b2-2- microglobulin and unmutated immunoglobulin heavy-chain variable region gene (IGHV). CLL patients with +12 and high LDH levels showed a shorter Progression-Free-Survival (PFS) (30 months vs. 65 months; p < 0.001), Treatment-Free-Survival (TFS) (33 months vs. 69 months; p < 0.001), Overall Survival (OS) (131 months vs. 181 months; p < 0.001) and greater CLL-related mortality (29% vs. 11% at 10 years; p < 0.001) when compared with +12 CLL patients with normal LDH levels. The same differences were observed in the validation cohort. These data suggest that serum LDH levels can predict PFS; TFS; OS and CLL-specific survival in CLL patients with +12

hTID-1 defines a novel regulator of c-Met Receptor signaling in renal cell carcinomas

The c-Met receptor tyrosine kinase (MetR) is frequently overexpressed and constitutively phosphorylated in a number of human malignancies. Activation of the receptor by its ligand, hepatocyte growth factor (HGF), leads to increased cell proliferation, motility, survival and disruption of adherens junctions. In this study, we show that hTid-1, a DNAJ/Hsp40 chaperone, represents a novel modulator of the MetR signaling pathway. hTid-1 is a co-chaperone of the Hsp70 family of proteins, and has been shown to regulate a number of cellular signaling proteins including several involved in tumorigenic and apoptotic pathways. In this study we demonstrate that hTid-1 binds to unphosphorylated MetR and becomes dissociated from the receptor upon HGF stimulation. Overexpression of the short form of hTid-1 (hTid-1S) in 786-0 renal clear cell carcinomas (RCCs) enhances MetR kinase activity leading to an increase in HGF-mediated cell migration with no discernible effect on cell proliferation. By contrast, knockdown of hTid-1 markedly impairs both the onset and amplitude of MetR phosphorylation in response to HGF without altering receptor protein levels. hTid-1-depleted cells display defective migratory properties, coincident with inhibition of ERK/MAP kinase and STAT3 pathways. Taken together, our findings denote hTid-1S as an essential regulatory component of MetR signaling. We propose that the binding of hTid-1S to MetR may stabilize the receptor in a ligand-competent state and this stabilizing function may influence conformational changes that take place during the catalytic cycle that promote kinase activation. Given the prevalence of HGF/MetR pathway activation in human cancers, targeted inhibition of hTid-1 may be a useful therapeutic in the management of MetR-dependent malignancies