Perdón y justicia en Ana Karenina

Cuando Alejo Karenina los perdona, ni Ana ni Wronskycomprenden por qué. ¿Es que ellos no se sientendignos del perdón? ¿O acaso lo ven como algo tanajeno al campo de la justicia que simplemente nopueden comprenderlo?¿Es justo perdonar? ¿Va el perdón “más allá de lojusto”? ¿Es posible que lo que resulta “insoportable”,cuando uno lleva una vida inmoral, no sea el castigo,sino precisamente el perdón   ARK: http://id.caicyt.gov.ar/ark:/s26184699/rckok19e5When Alejo Karenina forgives them, neither Ananor Wronsky understand why. Is it that they feelunworthy of forgiveness? Or perhaps they think itis something so distant to the field of justice thatthey simply cannot understand it?Is it fair to forgive? Is forgiveness “beyond fairness”?Is it possible that what is “unbearable”, when oneleads an immoral life, is not punishment, butprecisely forgiveness?   ARK: http://id.caicyt.gov.ar/ark:/s26184699/rckok19e

Candidate biomarkers from the integration of methylation and gene expression in discordant autistic sibling pairs

While the genetics of autism spectrum disorders (ASD) has been intensively studied, resulting in the identification of over 100 putative risk genes, the epigenetics of ASD has received less attention, and results have been inconsistent across studies. We aimed to investigate the contribution of DNA methylation (DNAm) to the risk of ASD and identify candidate biomarkers arising from the interaction of epigenetic mechanisms with genotype, gene expression, and cellular proportions. We performed DNAm differential analysis using whole blood samples from 75 discordant sibling pairs of the Italian Autism Network collection and estimated their cellular composition. We studied the correlation between DNAm and gene expression accounting for the potential effects of different genotypes on DNAm. We showed that the proportion of NK cells was significantly reduced in ASD siblings suggesting an imbalance in their immune system. We identified differentially methylated regions (DMRs) involved in neurogenesis and synaptic organization. Among candidate loci for ASD, we detected a DMR mapping to CLEC11A (neighboring SHANK1) where DNAm and gene expression were significantly and negatively correlated, independently from genotype effects. As reported in previous studies, we confirmed the involvement of immune functions in the pathophysiology of ASD. Notwithstanding the complexity of the disorder, suitable biomarkers such as CLEC11A and its neighbor SHANK1 can be discovered using integrative analyses even with peripheral tissues

Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world

Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States. Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis. Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection

Nebulized hypertonic saline containing hyaluronic acid improves tolerability in patients with cystic fibrosis and lung disease compared with nebulized hypertonic saline alone: a prospective, randomized, double-blind, controlled study

Background: Hypertonic saline inhalation has been shown to be effective in patients with cystic fibrosis and lung disease. However, adverse events including marked airway narrowing are reported and a bronchodilator must be given before the administration of the product. Methods: We carried out a prospective, randomized, double-blind, parallel-group, controlled study of a hypertonic saline solution containing hyaluronic acid (Hyaneb) versus standard hypertonic saline therapy to assess whether the presence of hyaluronic acid would improve the tolerability of hypertonic saline. Results and conclusions: The results showed that nebulized Hyaneb was more effective in reducing the need for β 2 bronchodilators and caused a significant reduction in the incidence of adverse effects compared with nebulized hypertonic saline solution alone. Its safety profile indicates that Hyaneb can be used for the treatment of lung disease in cystic fibrosis

Laboratory, imaging, cystoscopic, and pathological findings of the eight patients presenting with <i>Schistosoma haematobium</i> infection.

<p>Laboratory, imaging, cystoscopic, and pathological findings of the eight patients presenting with <i>Schistosoma haematobium</i> infection.</p

Representative ultrasonographic, cystoscopic, and pathological findings in a patient with chronic schistosomiasis presenting to the ED.

<p>(A) Ultrasonograph of the bladder shows a vegetation associated with bladder wall thickening; fine and diffuse calcifications are also visible. (B) Cystoscopic image obtained after transurethral resection shows an adult <i>S</i>. <i>haematobium</i> worm. (C) An area of marked, diffuse, acute inflammation with numerous eosinophils surrounds some calcified <i>S</i>. <i>haematobium</i> eggs; the parasite is also identified.</p