Articulated elastic-loop roving vehicles

Prototype vehicle features exceptional obstacle-negotiating and slope-climbing capabilities plus high propulsive efficiency. Concept should interest designers of polar or ocean-bottom research vehicles. Also, its large footprint and low ground pressure will minimize ecological damage on terrain with low bearing strength, as in off-the-road application

Control System Optimization for Saturn 5 Launch Vehicles Using Gradient Techniques Final Report

Control system optimization for Saturn 5 launch vehicles using gradient technique

The application of optimal control technqiues to advanced manned missions, volume 1

Two problems are presented in the area of optimal control and its application to the design of attitude control systems for advanced complex aerospace vehicles. The problems discussed are specification of performance criteria in terms of structural load minimization and/or maximum orbital payload injection requirements of the controlled vehicle; and formulation and solution of the optimization problem such that practical control systems are obtained

Green Island Union Free School District and Green Island Teachers Association

Proceeding Between Green Island Union Free School District And Green Island Teachers Association. PERB Case No. M 2009 ‐ 069. Report and Recommendations of Fact Finder, June 23, 2010 Donna Trautwein, Ph.D., Fact Finder

The application of optimal control techniques to advanced manned missions, volume 2

The hybrid optimization techique for attitude control design is described in detail. The technque is capable of optimizing an n-dimensional adjustable parameter vector, but a 1-dimensional vector is used as an example to explain the procedure. This permits an easier explanation as opposed to a multidimensional case. The procedure used to derive the perturbation equations of motion describing the 6-DOF shuttle ascent phase is presented. These equations were programmed on the EAI 8800 analog computer to describe the perturbations of the shuttle vehicle from a nominal zero lift trajectory due to wind disturbances. Included are the control system equations, trim equations, and wind angle of attack equations. Analog wiring diagrams, raw data and time-varying coefficients, and state variable responses during shuttle ascent are also considered

Претензионная работа по топливу для предприятий энергетики

Background and aims: CREB (cAMP response element binding protein) transcription factors are key regulators of homeostatic functions in the liver, and CRE binding is increased in hepatic inflammation. During chronic hepatitis B virus (HBV) infection, mutations or deletions in the pre-S region are frequently observed. These mutations can affect the pre-S2/S promoter controlling HBV envelope protein expression (hepatitis B surface antigen (HBsAg)) and have been associated with worsened clinical outcome. We aimed to test if CREB activation impacts on HBsAg expression. Methods: The effect of the CREB inducer protein kinase A (PKA) was tested by coexpression with HBV wild-type vector in vitro. Luciferase reporter gene constructs were cloned to identify novel regulatory regions for the HBV pre-S2/S promoter. Electrophoretic mobility shift assay (EMSA) gelshift and supershift experiments were conducted to confirm DNA transcription factor binding. Results: Coexpression of HBV and PKA resulted in HBV-S mRNA induction and enhanced small envelope protein expression. We identified a CREB binding motif in the transcribed part of the pre-S2 region, contributing to basal S promoter activity via binding of activating transcription factor 2 (ATF2). A second CREB motif closely linked to the S-ATG showed a similar binding pattern involving ATF2 and CREB1, without appearing essential for basal promoter activity. Moreover, a sequence in the pre-S2 region is responsible for further transcriptional induction via CREB activators such as PKA and forskolin. EMSA experiments indicate that CREB1 and ATF4 are involved in complex formation conferring PKA dependent promoter activation. Conclusions: Our data suggest a novel mechanism by which HBV may utilise CREB/PKA signal transduction pathways of hepatocytes to enhance its HBsAg expression during homeostasis and hepatic inflammation

ILLNESS IN PATIENTS FOLLOWING EXPOSURE TO DENTAL AEROSOLS *

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65789/1/j.1752-7325.1972.tb03939.x.pd