Efficacy of Artesunate + Sulfamethoxypyrazine/Pyrimethamine versus Praziquantel in the Treatment of Schistosoma haematobium in Children

BACKGROUND:This study was conducted to determine the efficacy of the antimalarial artemisinin-based combination therapy (ACT) artesunate +sulfamethoxypyrazine/pyrimethamine (As+SMP), administered in doses used for malaria, to treat Schistosoma haematobium in school aged children. METHODOLOGY/PRINCIPAL FINDINGS:The study was conducted in Djalakorodji, a peri-urban area of Bamako, Mali, using a double blind setup in which As+SMP was compared with praziquantel (PZQ). Urine samples were examined for Schistosoma haematobium on days -1, 0, 28 and 29. Detection of haematuria, and haematological and biochemical exams were conducted on day 0 and day 28. Clinical exams were performed on days 0, 1, 2, and 28. A total of 800 children were included in the trial. The cure rate obtained without viability testing was 43.9% in the As+SMP group versus 53% in the PZQ group (Chi(2) = 6.44, p = 0.011). Egg reduction rates were 95.6% with PZQ in comparison with 92.8% with As+SMP, p = 0.096. The proportion of participants who experienced adverse events related to the medication was 0.5% (2/400) in As+SMP treated children compared to 2.3% (9/399) in the PZQ group (p = 0.033). Abdominal pain and vomiting were the most frequent adverse events in both treatment arms. All adverse events were categorized as mild. CONCLUSIONS/SIGNIFICANCE:The study demonstrates that PZQ was more effective than As+SMP for treating Schistosoma haematobium. However, the safety and tolerability profile of As+SMP was similar to that seen with PZQ. Our findings suggest that further investigations seem justifiable to determine the dose/efficacy/safety pattern of As+SMP in the treatment of Schistosoma infections. TRIAL REGISTRATION:ClinicalTrials.gov NCT00510159

Temporal variation in body measurements in three Taurine cattle populations of Burkina Faso supports introgression of Zebu genes into West African Taurine cattle

A total of 769 adult females belonging to 3 taurine and one zebu cattle populations sampled in 3 provinces of Burkina Faso were assessed for 19 body measurements during two different years (2014 and 2018). The aim of this research was to identify temporal morphological variation in cattle bred in the humid southern zones to obtain empirical evidence supporting a possible introgression of zebu cattle genes into Gourounsi and Lobi taurine cattle breeds. Zebu cattle samples were used as out-group for both 2014 and 2018 subsets. Least square means of body measurements allowed to classify Burkina Faso taurine cattle into three subgroups according to body size (Gourounsi–Sanguié –GourS-, Gourounsi-Nahouri –GourN- and Lobi from the tallest to the smallest respectively). Principal Component Analysis suggested that in 2014, taurine populations were structured. Dispersion map constructed using the two first factors informed that the GourS population was well separated from both the Lobi and the GourN, which, in turn, overlapped. However, in 2018 a strong signal of homogenization was identified, with GourN partially overlapping the other two populations. Linear Discriminant Analysis suggested that about 20% of both GourS and GourN individuals were reciprocally misclassified. Clues for such increase have been pointed out by MANOVA analysis. Although on 2014, Lobi cattle was clearly smaller than Gourounsi and both GourS and GourN populations showed clear differences on body traits, on 2018 it could be assessed an increase in size in Lobi cattle and a strong homogenization signal within Gourounsi cattle. Zebu cattle gene flow southwards in Burkina Faso is likely to have caused these changes, suggesting a fast erosion of taurine cattle genetic background. Keywords: Body traits, quantitative traits, Gourounsi cattle, Lobi, Burkina Faso

Anti-Trypanosomal Activity of Guiera senegalensis on Trypanosoma brucei Infected Mice

Aqueous decoction of Guiera senegalensis leaves was studied orally and intraperitoneally for its antitrypanosomal activity on mice infected experimentally with Trypanosoma brucei brucei. After a phytochemical screening followed by an acute toxicity study on mice, the extract of plant was administered once daily for 2 days at doses of 60, 120 and 240 mg / kg orally and 15, 30 and 60 mg / kg intraperitoneally after infection. Then, parameters of parasitaemia, packed cell volume (PCV), mean survival time and body weight of the mice treated with the extract were measured and compared with positive (diminazene aceturate) and negative (distilled water) controls for 7 days in a row. Results indicate that the aqueous extract of G. senegalensis leaves contains tannins, flavonoids, saponosides, reducing compounds and anthocyanosides, alkaloids and coumarins. LD50 of the extract are 1264.49 mg / kg by oral route and 316.22 mg / kg by intraperitoneal route. The doses of 240 mg / kg by oral route and 15 and 60 mg / kg by intraperitoneal route of aqueous extract showed a mean survival time (5 days) comparable to the positive control. Parasitaemia level increased in all mice tested except in mice treated with diminazene aceturate during the post-infestation period. During this period, PCV and body weight of all mice decreased by both routes of administration. These results of the study show the pharmacological utility of G. senegalensis leaves in the control of TAA by herders / pastoralists and suggest continuing further bio-guided studies to isolate the active components of the plant in order to improve their efficiency. Keywords: In vivo test; Trypanosoma brucei brucei; Guiera senegalensis leaves; phytochemical screening; acute toxicity

Molecular Characteristics and Epidemiology of Meningococcal Carriage, Burkina Faso, 2003

Meningococcal serogroups are genetically diverse and short-lived in the African meningitis belt

Évaluation des problèmes critiques de la recherche et developpement agricole au Burkina Faso: Le cas de l’institut national des recherches agricoles du Burkina Faso (INERA)

Non-PRIFPRI1; ASTI; CRP2EPTD; PIMCGIAR Research Program on Policies, Institutions, and Markets (PIM

A unifying framework for specifying DEVS parallel and distributed simulation architectures

International audienceDEVS (Discrete Event System Specification) is an approach in the area of modeling and simulation that provides a means of specifying dynamic systems. A variety of DEVS tools have been implemented without a standard developmental guideline across the board, consequently revealing a lack of central frameworks for integrating heterogeneous DEVS simula-tors. When implementing a DEVS Simulator there are salient concepts that are intuitively defined, such as how events should be processed, what simulation architecture to use, what existing procedures (set of rules/algorithm) can be used, what should be the organizational architecture and so on. The aim of this paper is to propose a theoretical guide in building a DEVS distributed simulation as well as a formalization of underlying concepts to allow symbolic reasoning and automated code synthesis. From a review of existing implementation approaches, we propose a taxonomy of the identified concepts, including some formal definitions as they constitute the essential building blocks of performing Parallel Discrete-Event Simulation by utilizing DEVS. The contribution of this taxonomy and its impact as a unifying framework is that it provides a more systematic understanding of the process of constructing a DEVS simulator. Also, it offers an abstract way for integrating different and heterogeneous DEVS implementation strategies and thus can serve as a contribution to the ongoing DEVS standardization efforts

La Production sociale des ruptures de suivi médical des personnes vivant avec le VIH. De l’identification des processus à l’œuvre vers le renouvellement des réponses apportées ? L’exemple de Kayes au Mali

Les enjeux cliniques et thérapeutiques majeurs liés à la régularité du suivi médical des PVVIH amènent à analyser les processus qui peuvent conduire les individus à cesser le suivi de leur infection.Une enquête anthropologique a été conduite à Kayes, au Mali, en 2008-2009 par observation en milieu hospitalier et associatif et entretiens auprès de 24 PVVIH ayant cessé le suivi de leur infection à un moment donné et de 8 soignants impliqués dans la prise en charge des PVVIH.La production sociale des ruptures de suivi médical mise en exergue dans cette contribution incite à appréhender l’inobservance non pas comme un comportement individuel mais comme le symptôme de difficultés et dysfonctionnements perceptibles au niveau du vécu de la maladie par les personnes infectées, de la relation de soin et de la structure de prise en charge. À chacun de ces niveaux, sont identifiés des tensions (entre des systèmes de contraintes et de valeurs contradictoires par exemple), voire des dysfonctionnements (de l’offre et de la relation de soin) qui interagissent et favorisent les interruptions de suivi des PVVIH.Cette analyse permet de souligner la responsabilité partagée des acteurs dans la production des ruptures de suivi et appelle à un renouvellement des réponses apportées à l’inobservance (l’éducation thérapeutique par exemple) qui, focalisées sur les seuls patients, occultent les enjeux relationnels, organisationnels et structurels du phénomène