FINE NEEDLE ASPIRATION CYTOLOGY AS A DIAGNOSTIC TOOL; AN ASSESSMENT

The study is about breast lesions which is a common cause of mortality and morbidity among females. To avoid negative consequences, there is need for urgent diagnosis and treatment. Fine Needle Aspiration Cytology (FNAC) is a useful diagnostic tool and possess higher level of accuracy. In this study, the objective was to determine the accuracy of FNAC in diagnosis of palpable breast lumps. Additionally, the objective was to find the correlation between cytological findings and histopathological examination of surgical specimens. The methodology of the study was based on retrospective study method. FNAC of breast lump was conducted on 271 patients out of which 104 formed the base group. The results showed that there were 104 patients of base study who had average age of 32 years. There were 54 patients with lump in left breasts, and 46 patients with lump in right breasts and 4 patient had bilateral lump. There were 77 patients with benign, 34 patients with malignant, and 3 had atypica;/suspicious lesions on cytological examination. Based on histopathological examination, 77 cases were related to benign, 26 were related to malignant, and 1 with atypical/suspicious. Cyto-histological concurrence was 93.05% and 79.2% for Fibroadenoma and Infiltrating ductal carcinoma respectively. Overall sensitivity of FNAC procedure was 94.17%, specificity 100% and accuracy 93.26%.  On the basis of result, it is concluded that FNAC is a simple, reliable method for diagnosis of both benign and malignant lesions and can be used in the evaluation of breast lesions.

RESEARCH ON THE MANUFACTURING MAGNESIUM FROM THANHHOA DOLOMITE BY PIDGEON PROCESS

The magnesium and magnesium alloys has applied widely in different industrial aspects in Vietnam in the modern life. Especially, the products from magnesium alloys implementing in the automotive have increased rapidly since the car elements tend to be generated by the light alloys in order to save the fuel. However, in the current time, Vietnam has no factories to produce the magnesium to adapt the domestic demand although it owns an enrich resource of raw materials. This research indicates the possibility of using the dolomite ore in Thanhhoa – Vietnam to make the magnesium as well as evaluate the primary factors like recovering temperature, reducing agent rate, recovering time having effect on the reduction efficiency of Thanhhoa dolomite by metallothermic method in vacuum (Pidgeon Process). This is basic process, low investment and suitable for the small and medium scales in Vietnam. The experiment includes heating, indicating the chemical ingredients and recovering experiment on the dolomite after calcination (dolime) by using ferrosilicon. The thermodynamic model is created to estimate the recovering efficiency in the Pidgeon. The result shows that the CaO/MgO molar ratio of calcination dolomite in Thanhhoa is nearly 1.5 which is suitable to produce magnesium in the case of highly-required efficiency and pureness. Besides, the result from the furnace of the experiment is lower than the one in the model. The samples are set up to check the influence of the rate of ferrosilicon in the compound. The result indicates that the ideal efficiency reaches 85 % with 30 % ferrosilicon. Moreover, the study confirms that the optimal operating conditions in this process are recovering during three hours at 1200 °C and 100 Pa pressure. This result proves the potential application of Thanhhoa dolomite in the industry suitable with the current condition in Vietna

Evaluating the Ability to Achieve Efficiency in Providing Services of the Freight Forwarding Firms in Viet Nam

In recent years, Vietnam freight forwarding industry is growing and contributing significantly to the national GDP. However, the efficiency in providing service delivery at the domestic firms is not high to compete with multinational companies that are strong potential and finance. There have been many studies on freight forwarding, but mainly qualitative research and other studies are in-depth analysis logistics. This research presents the factors that affect efficiency in providing services. This research has been used factor analysis method and binary regression model (Binary Logistics) and identified 4 factors that affect the efficiency in providing service of freight forwarding firms: (1) Resources of business (2) Outcomes (3) The quality of staffs (4) The relationship between enterprises and their customers, and outcomes is the factor provided the highest positive correlation to the ability to achieve efficiency in providing services of freight forwarding firms.Binary Logistic model showed the probability of business efficiency is 72.5%. Thus, at the level of resources to provide services is 3.35, the outcome is 3.66, quality of the staffs is 3.59 and the relationship with customers is 3.40, shows that enterprises operate efficiently. Value prediction accuracy of the model is 93.3%

Effect of Polypyrrole on the Electrical, Dielectric and Mechanical Properties of Waterborne Epoxy Coatings

In this context, conducting composite based on waterborne epoxy system and polypyrrole (PPy) was investigated. The polypyrrole was synthesized by chemical oxidation polymerization. Its morphology and chemical structure were confirmed by using field emission scanning electron microscopy (FESEM) and Fourier transform infrared spectroscopy (FTIR). Then, PPy was well-dispersed in the epoxy coating and had a good compatibility with the matrix. The effects of PPy on dielectric, electrical and mechanical properties of epoxy/PPy composites was examined. The dielectric constant and electrical conductivity of the coatings increased with addition of PPy fillers. Over to 15 wt. % of PPy loading, the volume resistivity of samples slightly decreased from 6.7 × 1010 to 1.5 × 1010 Ω cm. In contrast, the presence of PPy diminished both impact and abrasion resistance of the epoxy/PPy composites, down to 160 kg cm and 10.2 L/mil, respectively, but they stayed acceptable for the coatings. The results reveal that the epoxy containing polypyrrole is suitable for various electrical and dielectric applications

EFFECT OF MODIFIED ATMOSPHERE PACKAGING (MAP) AND POSTHARVEST TREATMENTS ON QUALITY OF LITCHI FRUITS DURING STORAGE

In this article, effect of modified atmosphere packaging (MAP) and different postharvest treatments on quality of litchi (Litchi chinensis Sonn.) fruit was investigated. Quality indexes of litchi during cold storage at 4 ± 1 oC were measured in terms of decay, total soluble solids, titratable acidity, color, anthocyanin content and incidence of microbiological infection. These indexes were determined at harvest and 7, 14, 21, 28 and 35 days after storage. The results suggested that after 35 days of storage, the pericarp browning and fruit quality deterioration can be improved compared to the control by dipping fruit is hot water at 47 oC in 7 min., followed by oxalic acid solution (pH = 3 in 6 min.) and finally packed in MAP bag (LDPE, thickness of 30 µm incorporated 3-5 % silica additive) and stored at 4 ± 10C and relative humidity of 90 %

Optical Properties of Silicon Nanoparticles Prepared by Laser Ablation Method in Various Media

Bright photoluminescent silicon nanoparticles were successfully fabricated from porous silicon target in air and n-hexane using 532 nm line of YAG:Nd pulsed laser. The whole procedure was carried out at room temperature, in atmosphere. The morphology and composition of as-synthesized nanoparticles were characterized by SEM and EDS measurements. Their optical properties were investigated. The PL peak position of the as-synthesized Si nanoparticle ablated in air is slightly blue-shifted in comparison with those ablated in n-hexane, while it was almost no change of peak position of Si nanoparticles fabricated from p-Si in hexane and original p-Si wafer target. In contrast to PL intensity quenching of original p-Si sample and particles produced in air, those produced in n-hexane solvent exhibited an enhancement. The presence of dangling bonds or energy transfer from excited Si particles to oxygen molecules on the surface can be the cause of the quenching effect

Quantitative Proteomics Reveal an Altered Pattern of Protein Expression in Brain Tissue from Mice Lacking Gpr37 and Gpr37l1

GPR37 and GPR37L1 are glia-enriched G protein-coupled receptors that have been implicated in several neurological and neurodegenerative diseases. To gain insight into the potential molecular mechanisms by which GPR37 and GPR37L1 regulate cellular physiology, proteomic analyses of whole mouse brain tissue from wild-type (WT) versus GPR37/GPR37L1 double knockout (DKO) mice were performed in order to identify proteins regulated by the absence versus presence of these receptors (data are available via ProteomeXchange with identifier PXD015202). These analyses revealed a number of proteins that were significantly increased or decreased by the absence of GPR37 and GPR37L1. One of the most decreased proteins in the DKO versus WT brain tissue was S100A5, a calcium-binding protein, and the reduction of S100A5 expression in KO brain tissue was validated via Western blot. Coexpression of S100A5 with either GPR37 or GPR37L1 in HEK293T cells did not result in any change in S100A5 expression but did robustly increase secretion of S100A5. To dissect the mechanism by which S100A5 secretion was enhanced, cells coexpressing S100A5 with the receptors were treated with different pharmacological reagents. These studies revealed that calcium is essential for the secretion of S100A5 downstream of GPR37 and GPR37L1 signaling, as treatment with BAPTA-AM, an intracellular Ca2+ chelator, reduced S100A5 secretion from transfected HEK293T cells. Collectively, these findings provide a panoramic view of proteomic changes resulting from loss of GPR37 and GPR37L1 and also impart mechanistic insight into the regulation of S100A5 by these receptors, thereby shedding light on the functions of GPR37 and GPR37L1 in brain tissue

The identification of novel immunogenic antigens as potential Shigella vaccine components.

BACKGROUND: Shigella is a major diarrheal pathogen for which there is presently no vaccine. Whole genome sequencing provides the ability to predict and derive novel antigens for use as vaccines. Here, we aimed to identify novel immunogenic Shigella antigens that could serve as Shigella vaccine candidates, either alone, or when conjugated to Shigella O-antigen. METHODS: Using a reverse vaccinology approach, where genomic analysis informed the Shigella immunome via an antigen microarray, we aimed to identify novel immunogenic Shigella antigens. A core genome analysis of Shigella species, pathogenic and non-pathogenic Escherichia coli, led to the selection of 234 predicted immunogenic Shigella antigens. These antigens were expressed and probed with acute and convalescent serum from microbiologically confirmed Shigella infections. RESULTS: Several Shigella antigens displayed IgG and IgA seroconversion, with no difference in sero-reactivity across by sex or age. IgG sero-reactivity to key Shigella antigens was observed at birth, indicating transplacental antibody transfer. Six antigens (FepA, EmrK, FhuA, MdtA, NlpB, and CjrA) were identified in in vivo testing as capable of producing binding IgG and complement-mediated bactericidal antibody. CONCLUSIONS: These findings provide six novel immunogenic Shigella proteins that could serve as candidate vaccine antigens, species-specific carrier proteins, or targeted adjuvants

The identification of novel immunogenic antigens as potential Shigella vaccine components.

BACKGROUND: Shigella is a major diarrheal pathogen for which there is presently no vaccine. Whole genome sequencing provides the ability to predict and derive novel antigens for use as vaccines. Here, we aimed to identify novel immunogenic Shigella antigens that could serve as Shigella vaccine candidates, either alone, or when conjugated to Shigella O-antigen. METHODS: Using a reverse vaccinology approach, where genomic analysis informed the Shigella immunome via an antigen microarray, we aimed to identify novel immunogenic Shigella antigens. A core genome analysis of Shigella species, pathogenic and non-pathogenic Escherichia coli, led to the selection of 234 predicted immunogenic Shigella antigens. These antigens were expressed and probed with acute and convalescent serum from microbiologically confirmed Shigella infections. RESULTS: Several Shigella antigens displayed IgG and IgA seroconversion, with no difference in sero-reactivity across by sex or age. IgG sero-reactivity to key Shigella antigens was observed at birth, indicating transplacental antibody transfer. Six antigens (FepA, EmrK, FhuA, MdtA, NlpB, and CjrA) were identified in in vivo testing as capable of producing binding IgG and complement-mediated bactericidal antibody. CONCLUSIONS: These findings provide six novel immunogenic Shigella proteins that could serve as candidate vaccine antigens, species-specific carrier proteins, or targeted adjuvants

Effect of calcium chloride treatment by vacuum infiltration method on texture and shelf life of black cherry tomatoes (Solanum lycopersicum cv. OG)

The use of vacuum infiltration in the food industry has several advantages, such as improving the quality, eliminating chemical treatment requirements, stabilizing products, and retaining nutrients during storage and processing. This study was performed to optimize the vacuum level (516-684 mmHg), treatment time (10-20 min), and calcium chloride (CaCl2) concentration (0.58- 1.42%) using the Response Surface Methodology (RSM). The firmness of black cherry tomatoes (Solanum lycopersicum cv. OG) reached an optimum value (1477.81 g/cm2) when fruits were treated at a vacuum level of 637 mmHg with a concentration of CaCl2 1.09% for 17 min. Meanwhile, the firmness was 746 g/cm2 for the control sample, which was dipped in 1.42% CaCl2 solution for 20 min at the atmospheric condition. The scanning electron microscope (SEM) images of stomata of two samples with/without vacuum treatment were also significantly different. The sample after vacuum treatment at optimum parameters was put into PE and PP bags for storage at 10-12°C. Vacuum-infiltrated tomatoes contained in PE and PP bags had a corresponding storage time of 30 and 28 days. The control samples were maintained for shorter periods, only 22 and 20 days, respectively