18,591 research outputs found
A continuum-microscopic method based on IRBFs and control volume scheme for viscoelastic fluid flows
A numerical computation of continuum-microscopic model for visco-elastic flows based on the Integrated Radial Basis Function (IRBF) Control Volume and the Stochastic Simulation Techniques (SST) is reported in this paper. The macroscopic flow equations are closed by a stochastic equation for the extra stress at the microscopic level. The former are discretised by a 1D-IRBF-CV method while the latter is integrated with Euler explicit or Predictor-Corrector schemes. Modelling is very efficient as it is based on Cartesian grid, while the integrated RBF approach enhances both the stability of the procedure and the accuracy of the solution. The proposed method is demonstrated with the solution of the start-up Couette flow of the Hookean and FENE dumbbell model fluids
Wearable Sensor Data Based Human Activity Recognition using Machine Learning: A new approach
Recent years have witnessed the rapid development of human activity
recognition (HAR) based on wearable sensor data. One can find many practical
applications in this area, especially in the field of health care. Many machine
learning algorithms such as Decision Trees, Support Vector Machine, Naive
Bayes, K-Nearest Neighbor, and Multilayer Perceptron are successfully used in
HAR. Although these methods are fast and easy for implementation, they still
have some limitations due to poor performance in a number of situations. In
this paper, we propose a novel method based on the ensemble learning to boost
the performance of these machine learning methods for HAR
Hybridization gap and anisotropic far-infrared optical conductivity of URu2Si2
We performed far-infrared optical spectroscopy measurements on the heavy
fermion compound URu 2 Si 2 as a function of temperature. The light's
electric-field was applied along the a-axis or the c-axis of the tetragonal
structure. We show that in addition to a pronounced anisotropy, the optical
conductivity exhibits for both axis a partial suppression of spectral weight
around 12 meV and below 30 K. We attribute these observations to a change in
the bandstructure below 30 K. However, since these changes have no noticeable
impact on the entropy nor on the DC transport properties, we suggest that this
is a crossover phenomenon rather than a thermodynamic phase transition.Comment: To be published in Physical Review
A molecular perspective on the limits of life: Enzymes under pressure
From a purely operational standpoint, the existence of microbes that can grow
under extreme conditions, or "extremophiles", leads to the question of how the
molecules making up these microbes can maintain both their structure and
function. While microbes that live under extremes of temperature have been
heavily studied, those that live under extremes of pressure have been
neglected, in part due to the difficulty of collecting samples and performing
experiments under the ambient conditions of the microbe. However, thermodynamic
arguments imply that the effects of pressure might lead to different organismal
solutions than from the effects of temperature. Observationally, some of these
solutions might be in the condensed matter properties of the intracellular
milieu in addition to genetic modifications of the macromolecules or repair
mechanisms for the macromolecules. Here, the effects of pressure on enzymes,
which are proteins essential for the growth and reproduction of an organism,
and some adaptations against these effects are reviewed and amplified by the
results from molecular dynamics simulations. The aim is to provide biological
background for soft matter studies of these systems under pressure.Comment: 16 pages, 8 figure
Drug Interaction Study Of Apixaban With Cyclosporine Or Tacrolimus: Results From A Phase 1, Randomized, Open-Label, Crossover Study In Healthy Volunteers
BACKGROUND
Solid organ transplant recipients commonly require anticoagulation. Apixaban (APX) is principally metabolized by CYP3A4, undergoes direct intestinal excretion, and is a substrate to P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP) transporters. We examined the potential drug interaction between cyclosporine (CsA) and tacrolimus (Tac) [combined inhibitors of CYP3A4, P-gp and, BCRP] with APX.https://jdc.jefferson.edu/petposters/1005/thumbnail.jp
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