Probiotics Effect on Healthspan in the Model Organism Caenorhabditis elegans

In America, there are high rates of obesity and obesity related diseases partially due to a high glucose diet. Possessing a propensity towards reversing a glucose rich diet, probiotics, live microorganisms such as yogurt, were used to combat this. To experiment with humans let alone mice would be tedious, so, another organism-the microscopic nematode, Caenorhabditis elegans was used. Because C. elegans possesses homology with humans, they can be used to study probiotics with application in humans. Sponsored by the Creative Inquiry program, this project analyzed the relationship between different probiotics and their effect on lifespan. With Escherichia coli OP50 as the control and varying Lactobacillus strains as the experimental groups, lifespan assays were conducted. Our results show that certain probiotics increase the lifespan and reverse the consequences of a high glucose diet. Conversely, certain probiotic species, such as Lactobacillus plantarum, can decrease and promote negative health consequences in C. elegans. From these results, the understanding of the human microbiome and better treatments for obesity and obesity related diseases can be made

PERSPECTIVES OF SOCIAL WORK STUDENTS ON NUTRITION AND THE NUTRITION EFFECTS ON MENTAL HEALTH

Nutrition is related to the mental well-being of clients. However, the nutritional views and practices of social workers in the mental health field have not been thoroughly explored. By using the post-positivist paradigm, 15 mental health social work students were interviewed for their perspectives regarding nutrition and nutrition’s effect on stress. Their main ideas were identified, connected, and organized to develop a theoretical statement. The resulting theory focused on the development of social work students\u27 perspectives in applying nutrition into their mental health practice. The students were influenced by a variety of background factors, including their education, barriers to applying nutrition into their mental health practice, and solutions to the barriers. Background factors affected the students\u27 thoughts on nutrition, including their abstract thoughts, food, eating behaviors, and general well-being. The students\u27 thoughts influenced their application of mental health treatment with nutrition and its compounding variables. Lastly, the students suggested nutrition and mental health treatment approaches, which consisted of providing nutrition assessments, discussions, education, demonstrations, linkages, and macro interventions

Physiological Effects of Rhythmic Melatonin on Peripheral Cells in a Superfusion System

The immediate effects of melatonin from the pineal gland on peripheral cell types such as astrocytes, hepatocytes, and cardiac myocytes are relatively unknown. My research includes designing a superfusion or flow-through system that constantly pumps medium to light-entrained, chick pineal cells. The medium from the pinealocytes, enriched with pineal-specific secretions, will be directed to the above target cells, which are simultaneously housed in constant darkness. Radioimmunoassay for pineal melatonin and ELISA on the target cells’ secretions examines the effects of melatonin ex-vivo. This study will shed light on the direct effects of pineal melatonin on the central nervous system and peripheral organ cell types

The Glycemic, Cholesterol, and Weight Effects of L-carnitine in Diabetes: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Introduction L-carnitine possibly impacts insulin sensitivity and glucose metabolism. However, its therapeutic role in diabetes is poorly understood. Methods A systematic review and meta-analysis were conducted using PubMed, EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL) from inception through June 30, 2021. Included studies evaluated the use of L-carnitine in diabetes on fasting blood glucose (FBG), hemoglobin A1c (HbA1c), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), weight, or body mass index (BMI). Weighted mean difference (WMD) and 95% confidence intervals (CI) were calculated using the DerSimonian and Laird random-effects model. Results Seventeen studies involving 1622 patients were included. Reductions in FBG (WMD = -0.46 mmol/L, 95% CI = -0.68 to -0.23 mmol/L), HbA1c (WMD = -0.5%, 95% CI = -0.8 to -0.1%), TC (WMD = -0.29 mmol/L, 95% CI = -0.42 to -0.16 mmol/L), and LDL-C (WMD = -0.23 mmol/L, 95% CI = -0.39 to -0.07 mmol/L) were significant. Effects on HDL-C, TG, weight, or BMI were insignificant. Doses between 1001 to 2000 mg showed greatest benefit (p \u3c 0.02 for all). Discussion/Conclusion L-carnitine plays a potential role as adjunctive therapy in diabetes. Additional research is necessary for patients with higher baseline HbA1c and type 1 diabetes

Vad händer med personalens hälsa när kundens välbefinnande står i fokus? En studie om hälsofrämjande arbete inom spabranschen

Det har skett stora förändringar de senaste årtiondena inom arbetslivet som påverkar personalens hälsa. Nya risker har tillkommit gällande den psykosociala miljön på arbetsplatsen där många har svårt att hitta en balans mellan privat- och arbetsliv. Detta ställer stora krav på företag och ledare att arbeta hälsofrämjande. Inom personalintensiva verksamheter, vars arbetsuppgifter handlar om att ta hand om andra människors hälsa, är hälsofrämjande insatser av stor vikt då arbetet innebär en psykisk belastning för personalen. Det finns ett begränsat antal studier som fokuserar på hur hälsoföretag arbetar med hälsofrämjande frågor vilket leder till uppsatsens syfte. Syftet med uppsatsen är att undersöka hur serviceföretag inom hälsobranschen, med spa som exempel, arbetar för att skapa och upprätthålla en hälsofrämjande arbetsplats. Uppsatsens empiriska material är inhämtat genom kvalitativa intervjuer på fyra spa; Varbergs Kurort, Kivik Hotell & Konferens & Spa, Electa och Spa Njuta. Sammanlagt har tio intervjuer genomförts med fyra spachefer och sex spaterapeuter. Utifrån undersökningens resultat framkommer det att det är företagets skyldighet att säkerställa att det finns förutsättningar för personalen att upprätthålla en god hälsa. Vi konstaterar att man inom spa har långa och tunga arbetsdagar med ett ständigt fokus på kundernas hälsa. Detta resulterar i att personalens hälsa ofta bortprioriteras, vilket även återspeglar det hälsofrämjande arbetet. I undersökningen visade det sig hur företagen arbetade med hälsofrämjande aktiviteter som feedback, arbetsrotation och skapande av delaktighet. Det framkom även hur betydelsefullt ledarskapet var för personalen för att skapa en tillfredsställande arbetsplats. Den största motivationsfaktorn i arbetet var de sociala band som skapas på arbetsplatsen, till både kunder och kollegor

Perancangan Dan Implementasi Augmented Reality Sebagai Media Promosi Penjualan Perumahan

Untuk melakukan promosi sebuah Perumahan banyak cara yang dapat dilakukan, misalnya dengan menggunakan brosur yang mana informasinya disampaikan dalam media dua dimensi, maket yang mana informasinya sudah dapat disampaikan dalam media tiga dimensi tetapi harus memerlukan ruang yang tidak sedikit untuk mewujudkannya demi mendapatkan hasil yang maksimal. Yang menjadi masalah disini adalah bagaimana menjadikan suatu informasi tersebut menjadi interaktif dan lebih menarik bagi konsumen. Dengan menggunakan teknik promosi berbasis augmented reality yang dibuat dengan menggunakan ARTool Kit sebagai komponen yang utama dan dengan menggunakan 3DS Max sebagai software untuk menghasilkan gambar yang menarik. Proses perancangan dan pembuatan teknik promosiini akan menggunkan metode waterfall. Kelebihan dari model waterfall adalah struktur tahap pengembangan sistem jelas, dokumentasi dihasilkan disetiap tahap pengembangan, dan sebuah tahap dijalankan setelah tahap sebelumnya selesai dijalankan (tidak ada tumpang tindih pelaksanaan tahap). Hasil dari perancangan aplikasi ini adalah terealisasinya suatu aplikasi untuk kepentingan promosipenjualan Perumahan yang lebih menarik dan interaktif dengan konsumen berbasis augmented reality. Dengan adanya aplikasi ini diharapkan metode promosi dapat berkembang dengan lebih menarik dan tentunya dengan mengandalkan teknologitanpa membutuhkan ruang yang banyak untuk mencapai hasil yang maksimal

New Searches for Muonphilic Particles at Proton Beam Dump Spectrometers

We introduce a new search strategy for visibly decaying muonphilic particles using a proton beam spectrometer modeled after the SpinQuest experiment at Fermilab. In this setup, a ${\sim}$100 GeV primary proton beam impinges on a thick fixed target and yields a secondary muon beam. As these muons traverse the target material, they scatter off nuclei and can radiatively produce hypothetical muonphilic particles as initial- and final-state radiation. If such new states decay to dimuons, their combined invariant mass can be measured with a downstream spectrometer immersed in a Tesla-scale magnetic field. For a representative setup with $3\times 10^{14}$ muons on target with typical energies of $\sim$ 20 GeV, a $15\%$ invariant mass resolution, and an effective 100 cm target length, this strategy can probe the entire parameter space for which $\sim$ 200 MeV -- GeV scalar particles resolve the muon $g-2$ anomaly. We present sensitivity to these scalar particles at the SpinQuest experiment where no additional hardware is needed and the search could be parasitically executed within the primary nuclear physics program. Future proton beam dump experiments with optimized beam and detector configurations could have even greater sensitivity.Comment: v2: references added. v1: 16 pages, 11 figure