Action-Perception Matching in Human Cultural Evolution: Updates from the Cognitive Science Debate

Analyses of action-perception matching mechanisms, such as the Mirror Neuron System (MNS), have been prominent in evolutionary accounts of human cognition. Some scholars have interpreted data on the MNS to suggest that the human capacity to acquire and transmit cultural information is a learned product of cultural evolution (the Culture not Biology Account of cultural learning). Others have interpreted results related to the MNS to suggest that cultural learning in humans result from both cultural and biological evolution (the Culture per biology Account of cultural learning). In this paper, we analyse action-perception matching mechanisms considering evolutionary models and novel experimental findings about the MNS. We review the Culture not biology account plausibility within evolutionary theory and argue that as it stands this account is theoretically unsound. We finally argue for the plausibility of the Biology per culture account and discuss how it paves the way to further neurobiological investigations about the evolution of our capacity to learn, understand and transmit cultural information

Distributed loci of control: Overcoming stale dichotomies in biology and cognitive science

Abstract: We argue that theoretical debates in biology and cognitive science often are based around differences in the posited locus of control for biological and cognitive phenomena. Internalists about locus of control posit that specific causal control over the phenomenon is exerted by factors internal (to the relevant subsystem) of an organism. Externalists posit that causally specific influence is due to external factors. In theoretical biology, we suggest, a minimal agreement has developed that the locus of control for heritable variation is distributed – that is, both internal and external factors exert specific, non-redundant causal influence on evolved traits. We suggest that debates in cognitive science, particularly surrounding “enactivism”, should also embrace a distributed locus of control. We show how both internal and external factors contribute non-redundantly to psychological capacities and behavior. We further suggest that embracing a distributed locus of control provides a basis for a revisionary, but substantive account of “mental representation”.Keywords: Locus of control; Internalism/Externalism; Evolutionary Biology; Cognitive Science; Mental Representation Loci di controllo distribuiti: superare le vecchie dicotomie nella biologia e nella scienza cognitivaRiassunto: Numerose discussioni in biologia e nella scienza cognitiva vertono spesso su differenze nella individuazione del locus di controllo dei fenomeni biologici e cognitivi. Posizioni internaliste rispetto al locus di controllo ritengono che il controllo causale specifico su un fenomeno biologico o cognitivo venga esercitato da fattori interni a (un sottosistema rilevante) di un organismo. Al contrario, posizioni esternaliste assumono che specifiche influenze causali siano dovute a fattori esterni. In questo articolo mostriamo che nell’ambito della biologia teorica si è giunti a un minimo accordo rispetto al fatto che il locus di controllo per l’emergere di variazioni ereditarie è distribuito – ossia dovuto sia a fattori interni che esterni all’organismo che esercitano influenze specifiche e non-ridondanti sui tratti che si sono evoluti. Riteniamo che tale accordo debba essere raggiunto anche nell’ambito della scienza cognitiva, in particolare per quel che concerne l’enattivismo. In questo articolo mostriamo che sia i fattori interni che quelli esterni contribuiscono in maniera non-ridondante alle capacità psicologiche e al comportamento di un individuo. Inoltre sosterremo che l’adozione di un locus di controllo distribuito possa costituire un buon punto di partenza per una revisione sostanziale della nozione di “rappresentazione mentale”.Parole chiave: Locus di controllo causale; Internalismo/Esternalismo; Biologia evolutiva; Scienze cognitive; Rappresentazione mental

Acting up: An approach to the study of cognitive development

International audienceDespite decades of research, we lack a comprehensive framework to study and explain cognitive development. The emerging " paradigm " of action-based cognition implies that cognitive development is an active rather than a passive, automatic, and self-paced maturational process. Importantly, " active " refers to both sensorimotor activity (in the narrow sense) as well as to autonomous exploration (e.g., as found in active perception or active learning). How does this emphasis on action affect our understanding of cog-nitive development? Can an action-based approach provide a much-needed integrative theory of cognitive development? This chapter reviews key factors that infl uence development (including sensorimo-tor skills as well as genetic, social, and cultural factors) and their associated brain mechanisms. Discussion focuses on how these factors can be incorporated into a comprehensive action-based framework. Challenges are highlighted for future research (e.g., problems associated with explaining higher-level cognitive abilities and devising novel experimental methodologies). Although still in its infancy, an action-based approach to cognitive development holds promise to improve scientifi c understanding of cognitive development and to impact education and technology

“Natural Laboratory Complex” for novel primate neuroscience

We propose novel strategies for primate experimentation that are ethically valuable and pragmatically useful for cognitive neuroscience and neuropsychiatric research. Specifically, we propose Natural Laboratory Complex or Natural Labs, which are a combination of indoor-outdoor structures for studying free moving and socially housed primates in natural or naturalistic environment. We contend that Natural Labs are pivotal to improve primate welfare, and at the same time to implement longitudinal and socio-ecological studies of primate brain and behavior. Currently emerging advanced technologies and social systems (including recent COVID-19 induced “remote” infrastructures) can speed-up cognitive neuroscience approaches in freely behaving animals. Experimental approaches in natural(istic) settings are not in competition with conventional approaches of laboratory investigations, and could establish several benefits at the ethical, experimental, and economic levels

The evolution of skilled imitative learning: a social attention hypothesis

Humans are uncontroversially better than other species at learning from their peers. A key example of this is imitation, the ability to reproduce both the means and ends of others’ behaviours. Imitation is critical to the acquisition of a number of uniquely human cultural and cognitive traits. However, while authors largely agree on the importance of imitation, they disagree about the origins of imitation in humans. Some argue that imitation is an adaptation, connected to the ‘Mirror Neuron System’ that evolved to facilitate action understanding and the learning of social behaviours. Others argue that imitation is a cultural practice learned in childhood, and that there is no evidence that it evolved genetically. We offer a third alternative that is consistent with both data that the human brain is optimised for imitation, and consistent with its being substantially learned. We hypothesise that at some point in human history humans underwent natural selection for two imitation-relevant abilities – specifically, (i) the tendency to be more attentive to our peers, and (ii) fine motor skill in the manual and oro-facial domains. These changes enabled us to excel at both learning to imitate, and learning by imitating

Mirror neurons in the tree of life: mosaic evolution, plasticity and exaptation of sensorimotor matching responses

Considering the properties of mirror neurons (MNs) in terms of development and phylogeny, we offer a novel, unifying, and testable account of their evolution according to the available data and try to unify apparently discordant research, including the plasticity of MNs during development, their adaptive value and their phylogenetic relationships and continuity. We hypothesize that the MN system reflects a set of interrelated traits, each with an independent natural history due to unique selective pressures, and propose that there are at least three evolutionarily significant trends that gave raise to three subtypes: hand visuomotor, mouth visuomotor, and audio–vocal. Specifically, we put forward a mosaic evolution hypothesis, which posits that different types of MNs may have evolved at different rates within and among species. This evolutionary hypothesis represents an alternative to both adaptationist and associative models. Finally, the review offers a strong heuristic potential in predicting the circumstances under which specific variations and properties of MNs are expected. Such predictive value is critical to test new hypotheses about MN activity and its plastic changes, depending on the species, the neuroanatomical substrates, and the ecological niche

Economic Evaluations of Magnetic Resonance Image-Guided Radiotherapy (MRIgRT): A Systematic Review

Objectives: This review systematically summarizes the evidence on the economic impact of magnetic resonance image-guided RT (MRIgRT). Methods: We systematically searched INAHTA, MEDLINE, and Scopus up to March 2022 to retrieve health economic studies. Relevant data were extracted on study type, model inputs, modeling methods and economic results. Results: Five studies were included. Two studies performed a full economic assessment to compare the cost-effectiveness of MRIgRT with other forms of image-guided radiation therapy. One study performed a cost minimization analysis and two studies performed an activity-based costing, all comparing MRIgRT with X-ray computed tomography image-guided radiation therapy (CTIgRT). Prostate cancer was the target condition in four studies and hepatocellular carcinoma in one. Considering the studies with a full economic assessment, MR-guided stereotactic body radiation therapy was found to be cost effective with respect to CTIgRT or conventional or moderate hypofractionated RT, even with a low reduction in toxicity. Conversely, a greater reduction in toxicity is required to compete with extreme hypofractionated RT without MR guidance. Conclusions: This review highlights the great potential of MRIgRT but also the need for further evidence, especially for late toxicity, whose reduction is expected to be the real added value of this technology

Clinical and Molecular Spectrum of Myotonia and Periodic Paralyses Associated With Mutations in SCN4A in a Large Cohort of Italian Patients

Background: Four main clinical phenotypes have been traditionally described in patients mutated in SCN4A, including sodium-channel myotonia (SCM), paramyotonia congenita (PMC), Hypokaliemic type II (HypoPP2), and Hyperkaliemic/Normokaliemic periodic paralysis (HyperPP/NormoPP); in addition, rare phenotypes associated with mutations in SCN4A are congenital myasthenic syndrome and congenital myopathy. However, only scarce data have been reported in literature on large patient cohorts including phenotypes characterized by myotonia and episodes of paralysis. Methods: We retrospectively investigated clinical and molecular features of 80 patients fulfilling the following criteria: (1) clinical and neurophysiological diagnosis of myotonia, or clinical diagnosis of PP, and (2) presence of a pathogenic SCN4A gene variant. Patients presenting at birth with episodic laryngospasm or congenital myopathy-like phenotype with later onset of myotonia were considered as neonatal SCN4A. Results: PMC was observed in 36 (45%) patients, SCM in 30 (37.5%), Hyper/NormoPP in 7 (8.7%), HypoPP2 in 3 (3.7%), and neonatal SCN4A in 4 (5%). The median age at onset was significantly earlier in PMC than in SCM (p < 0.01) and in Hyper/NormoPP than in HypoPP2 (p = 0.02). Cold-induced myotonia was more frequently observed in PMC (n = 34) than in SCM (n = 23) (p = 0.04). No significant difference was found in age at onset of episodes of paralysis among PMC and PP or in frequency of permanent weakness between PP (n = 4), SCM (n = 5), and PMC (n = 10). PP was more frequently associated with mutations in the S4 region of the NaV1.4 channel protein compared to SCM and PMC (p < 0.01); mutations causing PMC were concentrated in the C-terminal region of the protein, while SCM-associated mutations were detected in all the protein domains. Conclusions: Our data suggest that skeletal muscle channelopathies associated with mutations in SCN4A represent a continuum in the clinical spectrum