305 research outputs found

    The employees of baby boomers generation, Generation X, Generation Y and Generation Z in selected Czech corporations as conceivers of development and competitiveness in their corporation

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    The corporations using the varied workforce can supply a greater variety of solutions to problems in service, sourcing, and allocation of their resources. The current labor market mentions four generations that are living and working today: the Baby boomers generation, the Generation X, the Generation Y and the Generation Z. The differences between generations can affect the way corporations recruit and develop teams, deal with change, motivate, stimulate and manage employees, and boost productivity, competitiveness and service effectiveness. A corporation’s success and competitiveness depend on its ability to embrace diversity and realize the competitive advantages and benefits. The aim of this paper is to present the current generation of employees (the employees of Baby Boomers Generation, Generation X, Generation Y and Generation Z) in the labor market by secondary research and then to introduce the results of primary research that was implemented in selected corporations in the Czech Republic. The contribution presents a view of some of the results of quantitative and qualitative research conducted in selected corporations in the Czech Republic. These researches were conducted in 2015 on a sample of 3,364 respondents, and the results were analyzed. Two research hypotheses and one research question have been formulated. The verification or rejection of null research hypothesis was done through the statistical method of the Pearson’s Chi-square test. It was found that perception of the choice of superior from a particular generation does depend on the age of employees in selected corporations. It was also determined that there are statistically significant dependences between the preference for heterogeneous or homogeneous cooperation and the age of employees in selected corporations

    Inhibition of GRK2, but not HSP90 Reduces Mitochondrial Superoxide and Improves Vasodilation Capacity of Coronary Arterioles from Aged Female Rats

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    Introduction: In post-menopausal women, small coronary microvessel dysfunction is the predominant heart disease presentation.There is currently no single treatment to tackle the multifactorial etiology of micro vessel dysfunction including oxidative stress, hyper constricted state, endothelial dysfunction, and blunted beta-adrenergic function. In the heart, G protein-coupled receptors (GPCRs), such as the b-adrenergic receptor (bADR) investigated in this experiment, are active in mediating vessel contractility vasodilation to facilitate blood flow. The presence of GPCR kinase 2 (GRK2), which inhibit bADRs, increase in old age and may mediate blunted capacity to vasodilate. Furthermore, GRK2 can be translocated to the mitochondria via heat shock protein 90 (HSP90), where it is responsible for accumulation of damaging reactive oxygen species (ROS). Increased ROS, in turn, may also contribute to blunted BADR response via desensitization, which is why understanding this mechanism is valuable in order to understand why treatments, such as the injection of adipose-derived Stomal Vascular Fraction (SVF), works in improving the coronary flow reserve. Our hypothesis is that coronary microvascular b-adrenergic desensitization in old age is influenced in part by oxidative stress mediated by GRK2 translocation to the mitochondria via HSP90, reversible by 17-DMAG (HSP90 inhibitor) or Paroxetine (GRK2 inhibitor) treatment. Furthermore, b-adrenergic desensitization, we hypothesize, is inducible in young age via exogenous ROS treatment. Methods: Female rat coronary arterioles isolated from young (3 months) and old (24 months) were mounted in a pressure myography system. Arterioles were infused with Mitosox (superoxide) and 2,3-diaminonapthalene (nitric oxide) and the vessels were incubated in 17-DMAG or Paroxetine for one hour. Changes in mean fluorescence intensity (MFI) were monitored to compare concentration of ROS within the arterioles. Old vessels were also subjected to bADR agonists(dobutamine (b1), salbutamol (b2), BRL (b3), isoproterenol (b1 and b2), and norepinephrine (b1 and a1/a2) in a dose response fashion in the presence or absence of paroxetine or 17-DMAG. Dose responses were also evaluated in young vessels with or without the presence of menadione (superoxide donor, 10 mM) and hydrogen peroxide (1 mM). Results:Paroxetine and 17-DMAG significantly reduced superoxide levels in OC compared to YC vessels. Paroxetine increases while 17-DMAG reduces NO density. Exogenous ROS treatment of young vessel attenuated vasodilation response to all beta agonists. For old vessels, the incubation in 17-DMAG did not restore vasodilation capacity, whereas previously we have shown that paroxetine significantly improves vasodilation response to norepinephrine. Conclusions: Coronary microvessel bADRfunction is blunted by elevated ROS, and is restored upon reduction of ROS through GRK2, but not HSP90 inhibition in the aged female rat. The presented data suggests microvessel bADR dysfunction may be linked to increased oxidative stress in age. Understanding mechanisms behind the pathophysiology of microvessel dysfunction including oxidative stress-linked bADR dysfunction is critical for designing therapies to target this disease.https://ir.library.louisville.edu/uars/1019/thumbnail.jp

    Assessing the Performance of LED-Based Flashlights Available in the Kenyan Off-Grid Lighting Market

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    Low cost rechargeable flashlights that use LED technology are increasingly available in African markets. While LED technology holds promise to provide affordable, high quality lighting services, the widespread dissemination of low quality products may make it difficult to realize this potential. This study includes performance results for three brands of commonly available LED flashlights that were purchased in Kenya in 2009. The performance of the flashlights was evaluated by testing five units for each of the three brands. The tests included measurements of battery capacity, time required to charge the battery, maximum illuminance at one meter, operation time and lux-hours from a fully charged battery, light distribution, and color rendering. All flashlights tested performed well below the manufacturers? rated specifications; the measured battery capacity was 30-50percent lower than the rated capacity and the time required to fully charge the battery was 6-25percent greater than the rated time requirement. Our analysis further shows that within each brand there is considerable variability in each performance indicator. The five samples within a single brand varied from each other by as much as 22percent for battery capacity measurements, 3.6percent for the number of hours required for a full charge, 23percent for maximum initial lux, 38percent for run time, 11percent for light distribution and by as much as 200percent for color rendering. Results obtained are useful for creating a framework for quality assurance of off-grid LED products and will be valuable for informing consumers, distributors and product manufacturers about product performance

    Learning about tools in infancy

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    These experiments explored the role of prior experience in 12-to 18-month-old infants' tool-directed actions. In Experiment 1, infants' use of a familiar tool (spoon) to accomplish a novel task (turning on lights inside a box) was examined. Infants tended to grasp the spoon by its handle even when doing so made solving the task impossible (the bowl did not fit through the hole in the box, but the handle did) and even though the experimenter demonstrated a bowl-grasp. In contrast, infants used a novel tool flexibly and grasped both sides equally often. In Experiment 2, infants received training using the novel tool for a particular function; 3 groups of infants were trained to use the tool differently. Later, infants' performance was facilitated on tasks that required infants to grasp the part of the tool they were trained to grasp. The results suggest that (a) infants' prior experiences with tools are important to understanding subsequent tool use, and (b) rather than learning about tool function (e.g., hammering), infants learn about which part of the tool is meant to be held, at least early in their exposure to a novel tool

    Identifying Bedrest Using Waist-worn Triaxial Accelerometers in Preschool Children

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    Purpose To adapt and validate a previously developed decision tree for youth to identify bedrest for use in preschool children. Methods Parents of healthy preschool (3-6-year-old) children (n = 610; 294 males) were asked to help them to wear an accelerometer for 7 to 10 days and 24 hours/day on their waist. Children with ≥3 nights of valid recordings were randomly allocated to the development (n = 200) and validation (n = 200) groups. Wear periods from accelerometer recordings were identified minute-by-minute as bedrest or wake using visual identification by two independent raters. To automate visual identification, chosen decision tree (DT) parameters (block length, threshold, bedrest-start trigger, and bedrest-end trigger) were optimized in the development group using a Nelder-Mead simplex optimization method, which maximized the accuracy of DT-identified bedrest in 1-min epochs against synchronized visually identified bedrest (n = 4,730,734). DT\u27s performance with optimized parameters was compared with the visual identification, commonly used Sadeh’s sleep detection algorithm, DT for youth (10-18-years-old), and parental survey of sleep duration in the validation group. Results On average, children wore an accelerometer for 8.3 days and 20.8 hours/day. Comparing the DT-identified bedrest with visual identification in the validation group yielded sensitivity = 0.941, specificity = 0.974, and accuracy = 0.956. The optimal block length was 36 min, the threshold 230 counts/min, the bedrest-start trigger 305 counts/min, and the bedrest-end trigger 1,129 counts/min. In the validation group, DT identified bedrest with greater accuracy than Sadeh’s algorithm (0.956 and 0.902) and DT for youth (0.956 and 0.861) (both P\u3c0.001). Both DT (564±77 min/day) and Sadeh’s algorithm (604±80 min/day) identified significantly less bedrest/sleep than parental survey (650±81 min/day) (both P\u3c0.001). Conclusions The DT-based algorithm initially developed for youth was adapted for preschool children to identify time spent in bedrest with high accuracy. The DT is available as a package for the R open-source software environment (“PhysActBedRest”)

    How climate change affects extremes in maize and wheat yield in two cropping regions

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    Author Posting. © American Meteorological Society, 2015. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of Climate 28 (2015): 4653–4687, doi:10.1175/JCLI-D-13-00326.1.Downscaled climate model projections from phase 5 of the Coupled Model Intercomparison Project (CMIP5) were used to force a dynamic vegetation agricultural model (Agro-IBIS) and simulate yield responses to historical climate and two future emissions scenarios for maize in the U.S. Midwest and wheat in southeastern Australia. In addition to mean changes in yield, the frequency of high- and low-yield years was related to changing local hydroclimatic conditions. Particular emphasis was on the seasonal cycle of climatic variables during extreme-yield years and links to crop growth. While historically high (low) yields in Iowa tend to occur during years with anomalous wet (dry) growing season, this is exacerbated in the future. By the end of the twenty-first century, the multimodel mean (MMM) of growing season temperatures in Iowa is projected to increase by more than 5°C, and maize yield is projected to decrease by 18%. For southeastern Australia, the frequency of low-yield years rises dramatically in the twenty-first century because of significant projected drying during the growing season. By the late twenty-first century, MMM growing season precipitation in southeastern Australia is projected to decrease by 15%, temperatures are projected to increase by 2.8°–4.5°C, and wheat yields are projected to decline by 70%. Results highlight the sensitivity of yield projections to the nature of hydroclimatic changes. Where future changes are uncertain, the sign of the yield change simulated by Agro-IBIS is uncertain as well. In contrast, broad agreement in projected drying over southern Australia across models is reflected in consistent yield decreases for the twenty-first century. Climatic changes of the order projected can be expected to pose serious challenges for continued staple grain production in some current centers of production, especially in marginal areas.This work was initiated at the Dissertations Initiative for the Advancement of Climate Change Research (DISCCRS) V Symposium, supported by the U.S. National Science Foundation through collaborative Grants SES-0932916 and SES-0931402. CCU was supported by a University of New South Wales Vice-Chancellor Fellowship and the Penzance Endowed Fund and John P. Chase Memorial Endowed Fund at WHOI. TET was supported by the U.S. Department of Energy Award DE-EE0004397. NC was funded by NSF Grant EAR-1204774. We are indebted to the FORMAS-funded Land Use Today and Tomorrow (LUsTT) project (Grant 211-2009-1682) for financial support

    Assessment of SNAP Utilization and Accessibility in Vermont

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    Food insecurity exemplifies one of the many public health crises that the COVID19 pandemic both exposed and amplified. In 2019 an estimated 10.5% of households (13.7 million households) were food insecure as determined by the US Department of Agriculture (USDA) including 5.3 million children. In 2020 this number increased to 15.6% of households, including 17.0 million children as projected by Feeding America. Food insecurity in children, especially in infancy, is associated with the development of obesity and hyperlipidemia, highlighting the necessity of federal and state food assistance programs. We believe that increased funding for SNAP incentive programs and wireless EBT devices for Farmers will result in a longitudinal and sustainable increase in produce consumption among low income individuals in VT. We hypothesize such changes will ultimately result in improved health outcomes and decreased burden on Vermont Medicaid systems.https://scholarworks.uvm.edu/comphp_gallery/1306/thumbnail.jp
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