669 research outputs found
Therapy with recombinant human antithrombin, heparin and tissue plasminogen activator improves survival and reduces ventilation days in a long-term ovine model of cutaneous burn and smoke inhalation injury
Ligandâinduced donor state destabilisation â a new route to panchromatically absorbing cu(I) complexes
The intense absorption of light to covering a large part of the visible spectrum is highly desirable for solar energy conversion schemes. To this end, we have developed novel anionic bis(4 H âimidazolato)Cu(I) complexes (cuprates), which feature intense, panchromatic light absorption properties throughout the visible spectrum and into the NIR region with extinction coefficients up to 28,000â
M â1 âcm â1 . Steadyâstate absorption, (spectro)electrochemical and theoretical investigations reveal low energy (Vis to NIR) metalâtoâligand chargeâtransfer absorption bands, which are a consequence of destabilized copperâbased donor states. These highâlying copperâbased states are induced by the Ïâdonation of the chelating anionic ligands, which also feature low energy acceptor states. The optical properties are reflected in very low, copperâbased oxidation potentials and three ligandâbased reduction events. These electronic features reveal a new route to panchromatically absorbing Cu(I) complexes.Cu(I) and two chelating , anionic polymethineâtype ligands form a novel type of photoactive cuprate. The ligands induce the destabilisation of the Cu(I)âbased donor states and act themselves as acceptors. This leads to an unusually broad and intense absorption spectrum with metalâtoâligand chargeâtransfer transitions from the visible to nearâinfrared region. imag
Three-tangle for mixtures of generalized GHZ and generalized W states
We give a complete solution for the three-tangle of mixed three-qubit states
composed of a generalized GHZ state, a|000>+b|111>, and a generalized W state,
c|001>+d|010>+f|100>. Using the methods introduced by Lohmayer et al. we
provide explicit expressions for the mixed-state three-tangle and the
corresponding optimal decompositions for this more general case. Moreover, as a
special case we obtain a general solution for a family of states consisting of
a generalized GHZ state and an orthogonal product state
Short-term alpha- or gamma-delta-enriched tocopherol oil supplementation differentially affects the expression of proinflammatory mediators: selective impacts on characteristics of protein tyrosine nitration in vivo
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Photophysics of Anionic Bis(4H-imidazolato)CuI Complexes
In this paper, the photophysical behavior of four panchromatically absorbing, homoleptic bis(4H-imidazolato)CuI complexes, with a systematic variation in the electron-withdrawing properties of the imidazolate ligand, were studied by wavelength-dependent time-resolved femtosecond transient absorption spectroscopy. Excitation at 400, 480, and 630 nm populates metal-to-ligand charge transfer, intraligand charge transfer, and mixed-character singlet states. The pump wavelength-dependent transient absorption data were analyzed by a recently established 2D correlation approach. Data analysis revealed that all excitation conditions yield similar excited-state dynamics. Key to the excited-state relaxation is fast, sub-picosecond pseudo-Jahn-Teller distortion, which is accompanied by the relocalization of electron density onto a single ligand from the initially delocalized state at Franck-Condon geometry. Subsequent intersystem crossing to the triplet manifold is followed by a sub-100 ps decay to the ground state. The fast, nonradiative decay is rationalized by the low triplet-state energy as found by DFT calculations, which suggest perspective treatment at the strong coupling limit of the energy gap law
Patient-derived iPSC-cerebral organoid modeling of the 17q11.2 microdeletion syndrome establishes CRLF3 as a critical regulator of neurogenesis
Neurodevelopmental disorders are often caused by chromosomal microdeletions comprising numerous contiguous genes. A subset of neurofibromatosis type 1 (NF1) patients with severe developmental delays and intellectual disability harbors such a microdeletion event on chromosome 17q11.2, involving the NF1 gene and flanking regions (NF1 total gene deletion [NF1-TGD]). Using patient-derived human induced pluripotent stem cell (hiPSC)-forebrain cerebral organoids (hCOs), we identify both neural stem cell (NSC) proliferation and neuronal maturation abnormalities in NF1-TGD hCOs. While increased NSC proliferation results from decreased NF1/RAS regulation, the neuronal differentiation, survival, and maturation defects are caused by reduced cytokine receptor-like factor 3 (CRLF3) expression and impaired RhoA signaling. Furthermore, we demonstrate a higher autistic trait burden in NF1 patients harboring a deleterious germline mutation in the CRLF3 gene (c.1166T\u3eC, p.Leu389Pro). Collectively, these findings identify a causative gene within the NF1-TGD locus responsible for hCO neuronal abnormalities and autism in children with NF1
German Nuclear Phase-Out Policy: Effects on European Electricity Wholesale Prices, Emission Prices, Conventional Power Plant Investments and Eletricity Trade
Isometries, submetries and distance coordinates on Finsler manifolds
This paper considers fundamental issues related to Finslerian iso-
metries, submetries, distance and geodesics. It is shown that at each
point of a Finsler manifold there is a distance coordinate system. Us-
ing distance coordinates, a simple proof is given for the Finslerian
version of the Myers-Steenrod theorem and for the differentiability of
Finslerian submetries
Refunding ETS-Proceeds to Spur the Diffusion of Renewable Energies: An Analysis Based on the Dynamic Oligopolistic Electricity Market Model Emelie
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