1,379 research outputs found
Compatibility testing of spacecraft materials and spacestorable liquid propellants
Compatibility data for aluminum alloy 2219-T87 and titanium alloy Ti-6Al-4V were obtained while these alloys were exposed to both liquid and vapor fluorine and FLOX at -320 F + or -10 F. These data were obtained using a new low cost compatibility method which incorporates totally sealed containers and double dogbone test specimens and propellants in the simultaneous exposure to vapor and liquid phases. The compatibility investigation covered a storage period in excess of one year. Pitting was more severe in the 2219-T87 aluminum alloy than in the Ti-6Al-4V titanium alloy for both fluorine and FLOX exposure. The degree of chemical attack is more severe in the presence of FLOX than in fluorine and phase. The mechanical properties of the two alloys were not affected by storage in either of the two propellants
Heat Transfer Analysis of a Lamphouse from a Typical Color Photographic Printer
High-speed operatorless photographic printers require high illumination levels at the negative print gate from lamps with stable color temperatures. The lamps using in these applications give off a large amount of heat radiation that is harmful to photographic emulsions as well as printer components and must be removed. This report describes how a typical photographic printer lamphouse separates the visible energy from the infrared, delivers the visible energy to the negative to be printed, and removes the infrared energy from the housing. This report also develops a set of empirically derived equations, which analytically describe the cooling mechanisms. These equations are intended to be useful design tools in future printer lamphouse development
Long term storage test of titanium material with liquid fluorine propellant
The compatibility of 6AL-4V Ti with propellant grade GF2 and LF2 at 77 K for up to 3 years was investigated. Titanium double coupons, annealed or heat treated, with 16 or 64 RMS finishes, were immersed in F2 in individual Pyrex capsules and stored under LN2 for 29 and 39 months. Pre and post immersion tests were performed on the propellant and coupons. Chemical analysis of the propellant did not reveal any significant changes due to titanium corrosion. Gravimetric, visual, microscopic, and metallurgical examination with pitting analysis did not reveal gross corrosion of the titanium although pitting appears to be greater after 39 months exposure. The increase in pit size and number raises the possibility of unpredictable crack propagation instability. Fracture toughness tests are necessary to define this possibility
Dynamic lot sizing for a warm/cold process: Heuristics and insights
Cataloged from PDF version of article.We consider the dynamic lot sizing problem for a warm/cold process where the process can be kept
warm at a unit variable cost for the next period if more than a prespecified quantity has been produced.
Exploiting the optimal production plan structures, we develop nine rule-based forward solution
heuristics. Proposed heuristics are modified counterparts of the heuristics developed previously for
the classical dynamic lot sizing problem. In a numerical study, we investigate the performance of the
proposed heuristics and identify operating environment characteristics where each particular heuristic
is the best or among the best. Moreover, for a warm/cold process setting, our numerical studies indicate
that, when used on a rolling horizon basis, a heuristic may also perform better costwise than a solution
obtained using a dynamic programming approach.
& 2012 Elsevier B.V. All rights reserved
Magneto-optical properties of multilayer graphenes
The magneto-optical absorption properties of graphene multilayers are
theoretically studied. It is shown that the spectrum can be decomposed into
sub-components effectively identical to the monolayer or bilayer graphene,
allowing us to understand the spectrum systematically as a function of the
layer number. Odd-layered graphenes always exhibit absorption peaks which
shifts in proportion to sqrt(B), with B being the magnetic field, due to the
existence of an effective monolayer-like subband. We propose a possibility of
observing the monolayer-like spectrum even in a mixture of multilayer graphene
films with various layers numbers.Comment: 9 pages, 7 figure
Single Item Lot Sizing Problem for a Warm/Cold Process with Immediate Lost Sales
Cataloged from PDF version of article.We consider the dynamic lot-sizing problem with finite capacity and possible lost sales for a process that could be kept
warm at a unit variable cost for the next period t + 1 only if more than a threshold value Qt has been produced and would
be cold, otherwise. Production with a cold process incurs a fixed positive setup cost, Kt and setup time, St, which may be
positive. Setup costs and times for a warm process are negligible. We develop a dynamic programming formulation of the
problem, establish theoretical results on the structure of the optimal production plan in the presence of zero and positive
setup times with Wagner–Whitin-type cost structures. We also show that the solution to the dynamic lot-sizing problem
with lost sales are generated from the full commitment production series improved via lost sales decisions in the presence of
a warm/cold process.
2006 Elsevier B.V. All rights reserved
Capital structure and its determinants in the United Kingdom – a decompositional analysis
Prior research on capital structure by Rajan and Zingales (1995) suggests that the level of gearing in UK companies is positively related to size and tangibility, and negatively correlated with profitability and the level of growth opportunities. However, as argued by Harris and Raviv (1991), 'The interpretation of results must be tempered by an awareness of the difficulties involved in measuring both leverage and the explanatory variables of interest'. In this study the focus is on the difficulties of measuring gearing, and the sensitivity of Rajan and Zingales' results to variations in gearing measures are tested. Based on an analysis of the capital structure of 822 UK companies, Rajan and Zingales' results are found to be highly definitional-dependent. The determinants of gearing appear to vary significantly, depending upon which component of debt is being analysed. In particular, significant differences are found in the determinants of long- and short-term forms of debt. Given that trade credit and equivalent, on average, accounts for more than 62% of total debt, the results are particularly sensitive to whether such debt is included in the gearing measure. It is argued, therefore, that analysis of capital structure is incomplete without a detailed examination of all forms of corporate debt
CCN6 Knockdown Disrupts Acinar Organization of Breast Cells in Three-dimensional Cultures through Up-regulation of Type III TGF-β Receptor
AbstractWhile normal cells in the human breast are organized into acinar structures, disruption of the acinar architecture is a hallmark of cancer. In a three-dimensional model of morphogenesis, we show that down-regulation of the matrix-associated tumor suppressor protein CCN6 (WNT1-inducible-signaling pathway protein 3) disrupts breast epithelial cell polarity and organization into acini through up-regulation of the type III transforming growth factor-β receptor (TβRIII or betaglycan). Down-regulation of CCN6 in benign breast cells led to loss of tissue polarity and resulted in cellular disorganization with loss of α6 integrin-rich basement membrane and the basolateral polarity protein E-cadherin. Silencing of TβRIII with shRNA and siRNA rescued the ability of breast epithelial cells to form polarized acinar structures with reduced matrix invasion and restored the correct expression of α6 integrin and E-cadherin. Conversely, CCN6 overexpression in aggressive breast cancer cells reduced TβRIII in vitro and in a xenograft model of CCN6 overexpression. The relevance of our studies to human breast cancer is highlighted by the finding that CCN6 protein levels are inversely associated with TβRIII protein in 64%of invasive breast carcinomas. These results reveal a novel function of the matricellular protein CCN6 and establish a mechanistic link between CCN6 and TβRIII in maintaining acinar organization in the breast
Erythrocyte Antibodies in AIDS are associated with mycobacteriosis and hypergammaglobulinemia
Upwelling-Level Acidification and pH/pCO2 Variability Moderate Effects of Ocean Acidification on Brain Gene Expression in the Temperate Surfperch, Embiotoca jacksoni
Acidification-induced changes in neurological function have been documented in several tropical marine fishes. Here, we investigate whether similar patterns of neurological impacts are observed in a temperate Pacific fish that naturally experiences regular and often large shifts in environmental pH/pCO2. In two laboratory experiments, we tested the effect of acidification, as well as pH/pCO2 variability, on gene expression in the brain tissue of a common temperate kelp forest/estuarine fish, Embiotoca jacksoni. Experiment 1 employed static pH treatments (target pH = 7.85/7.30), while Experiment 2 incorporated two variable treatments that oscillated around corresponding static treatments with the same mean (target pH = 7.85/7.70) in an eight-day cycle (amplitude ± 0.15). We found that patterns of global gene expression differed across pH level treatments. Additionally, we identified differential expression of specific genes and enrichment of specific gene sets (GSEA) in comparisons of static pH treatments and in comparisons of static and variable pH treatments of the same mean pH. Importantly, we found that pH/pCO2 variability decreased the number of differentially expressed genes detected between high and low pH treatments, and that interindividual variability in gene expression was greater in variable treatments than static treatments. These results provide important confirmation of neurological impacts of acidification in a temperate fish species and, critically, that natural environmental variability may mediate the impacts of ocean acidification
- …