God topledelse er en konstant forbedringsrejse

Ved årsskiftet starter en ny fire-årig valgperiode i kommunerne, og det er en god anledning til, at vi i den administrative topledelse retter blikket indad og ser på, hvordan vi hele tiden kan blive bedre til at bedrive administrativ topledelse. For mig handler det bl.a. om, at vi skal være skarpe på vores rolle i samspillet med politikerne, om hele tiden at lære og udvikle sig som topleder og sidst men ikke mindst om at sikre mere diversitet på ledelsesgangene

The dual nature of causation : two necessary and jointly sufficient conditions

In this dissertation, I propose a reductive account of causation. This account may be stated as follows: Causation: is a cause of within a possibility horizon ℋ iff a) is process-connected to , and b) security-depends on within ℋ. More precisely, my suggestion is that there are two kinds of causal relata: instantaneous events (defined in Chapter 4) and possibility horizons (defined in Chapter 5). Causation is a ternary relation between two actual instantaneous events – the cause and the effect – and a possibility horizon ℋ. I argue that causation has a dual nature: on the one hand, a cause must be connected to its effect via a genuine process; on the other hand, a cause must make a difference to its effect. The first condition – namely, the condition of process-connection (defined in Chapter 6) – captures the sense in which a cause must be connected to its effect via a genuine process. This condition allows my account to separate causation from mere correlation, distinguish genuine causes from preempted backups, and capture how a cause must be at the right level of detail relative to its effect (Chapter 7). The second condition – namely, the condition of security-dependence (defined in Chapter 8) – captures the sense in which a cause must make a difference to its effect. This condition allows my account to yield intuitively correct verdicts on the counterexamples to the transitivity and intrinsicness of causation, resolve the problem of profligate omissions, accommodate structurally isomorphic but causally different cases, and handle contrastive causal claims (Chapter 9 and 10). Finally, my proposed account of causation logically entails restricted versions of three important principles of causal reasoning concerning the sufficiency of counterfactual dependence for causation, and the transitivity and intrinsicness of causation (Chapter 11)

Relativizing proportionality to a domain of events

A cause is proportional to its effect when, roughly speaking, it is at the right level of detail. There is a lively debate about whether proportionality is a necessary condition for causation. One of the main arguments against a proportionality constraint on causation is that many ordinary and seemingly perfectly acceptable causal claims cite causes that are not proportional to their effects. In this paper, I suggest that proponents of a proportionality constraint can respond to this objection by developing an idea that is present in Yablo’s early work on proportionality, but which has strangely been ignored by both Yablo and others in the subsequent debate. My suggestion is that proportionality—and, indeed, causation itself—is relative to a domain of events. At the metaphysical level, this means that the causal relation has an extra relatum—namely, a domain of events. At the level of language, it introduces a new way in which causal claims are context-sensitive: what is expressed by a causal claim depends on the contextually relevant domain of events. As I argue, this suggestion allows us to accommodate the truth of ordinary causal claims while extending the explanatory benefits of a proportionality constraint

Case report:Evolution of pulmonary manifestations and virological markers in critical COVID-19 infection in Bruton's agammaglobulinemia

Despite several reports and small case series on the disease course of SARS-CoV-2 infection in patients with inborn errors of immunity (IEI), including X-linked agammaglobulinemia (XLA), this topic remains incompletely described. Here we present the case of a 38-year-old unvaccinated man with XLA, who acquired SARS-CoV-2 infection and experienced a protracted disease course with 47 days of SARS-CoV-2 positivity, critical COVID-19 with respiratory insufficiency necessitating intensive care and ventilatory support, and prompting repeated intensified treatments with remdesivir, dexamethasone, and monoclonal antibodies to eventually control infection. We describe the disease course and treatment and review the current literature on COVID-19 susceptibility and evidence for vaccine efficacy in patients with XLA