Dynamic Sealing Using Magneto-Rheological Fluids

Micropumps are microfluidic components which are widely used in applications such as chemical analysis, biological sensing and micro-robots. However, one obstacle in developing micropumps is the extremely low efficiency relative to their macro-scale counterparts. This paper presents a dynamic sealing method for external gear pumps to reduce the volumetric losses through the clearance between the tips of gears and the housing by using magneto-rheological (MR) fluids. By mitigating these losses, we are able to achieve high efficiency and high volumetric accuracy with current mechanical architectures and manufacturing tolerances. Static and dynamic sealing using MR fluids are investigated theoretically and experimentally. Two Mason numbers $Mn\left(p\right)$ and $Mn\left(\Omega\right)$ which are defined in terms of pressure gradient of the flow and velocity of the moving boundary respectively are used to characterize and evaluate the sealing performance. A range of magnetic field intensities is explored to determine optimal sealing effectiveness, where effectiveness is evaluated using the ratio of volumetric loss and friction factor. Finally, we quantify the effectiveness of this dynamic sealing method under different working conditions for gear pumps.Comment: 9 pages; 10 figures

An optimal condition based maintenance scheduling for metal structures based on a multidisciplinary research approach

Latest research findings show that the deterioration of metal coatings results due to complex combination of material and meteorological parameters. The classical maintenance scheduling do not consider complex interface of materials and meteorological parameters to determine optimal maintenance framework. The cost of recoating can be optimised through appropriate selection of coating specifications and maintenance strategy. This research provides a multidisciplinary algorithmic approach to determine cost-effective solutions for recoating. The specifications of red oxide primer coating and structural steel substrate system are considered for simulation analysis. The results show that the appropriate selection of 10% increase in coating thickness based on coating-substrate system specifications resulted in 20-25% reduction in annual patch failures which reduces 5-6 % cost of recoating. Furthermore, the proposed model also simulated to compare Patch recoating and Part recoating strategy and algorithm show that the Part recoating is cost-effective as compared to Patch recoating if number of annual patch failure is greater than ‘2’ and area of the part is ‘2x’times larger than the area of the patch. Contrary, the Patch recoating results in low cost if the part area is ‘10x’ times larger than patch area and number of annual patch failures are less than ‘7’

Adaptive optics imaging and integral field spectroscopy of APM 08279+5255: Evidence for gravitational lensing

We report observations of the z = 3.87 broad absorption line quasar APM 08279+5255 (Irwin et al. 1998) with the Adaptive Optics Bonnette (AOB) of the Canada-France-Hawaii Telescope. The object is found to be a double source. The separation of the two images is 0.35" +/- 0.02" and the intensity ratio I_{north}/I_{south} = 1.21 +/- 0.25 in the H-band. No other image is detected down to H(5sigma) = 21.3 within 10" from the double image. Strong support for the lensing hypothesis comes from the uniformity of the quasar spectrum as a function of spatial position in the image obtained with the integral field spectrograph OASIS at CFHT. From the 2D-spectroscopy, narrow-band images are reconstructed over the wavelength range 5600-6200A to search for emission-line objects in a field of 15"x12" around the quasar. We find no such object to a limit of 6x10^{-17} erg cm^{-2} s^{-1}. We use the images centered on the deepest absorption lines of the Ly-alpha forest to dim the quasar and to increase the sensitivity closer to the line of sight. One of the images, centered at 5766.4A, exhibits a 3sigma excess 1.5" from the quasar to the north-east

Improved production of automotive parts by intensive quench processing

Intensive quenching offers enormous potential advantages to the automotive component and processdesigner, including: possible elimination of more environmentally hazardous petroleum oils and aqueouspolymer quenchants, elimination of fire hazards associated with the use of petroleum oil quenchants,reduction or elimination of cracking, the possibilities of using less expensive steels in component design,dramatic improvement in properties such as fatigue and impact strength, and reduction or eliminationof carburizing times. In this paper, an overview of intensive quench processing is provided.Various case histories illustrating the use of intensive quenching to replaceconventional quenching process is also provided

Injury Due to Mechanical Falls: Future Directions in Gender-specific Surveillance, Screening, and Interventions in Emergency Department Patients.

The Centers for Disease Control and Prevention report that among older adults (≥65 years), falls are the leading cause of injury-related death. Fall-related fractures among older women are more than twice as frequent as those for men. Gender-specific evidence-based fall prevention strategy and intervention studies show that improved patient-centered outcomes are elusive. There is a paucity of emergency medicine literature on the topic. As part of the 2014 Academic Emergency Medicine (AEM) consensus conference on Gender-Specific Research in Emergency Care: Investigate, Understand, and Translate How Gender Affects Patient Outcomes, a breakout group convened to generate a research agenda on priority questions to be answered on this topic. The consensus-based priority research agenda is presented in this article

Optical spectroscopy of the M15 intermediate velocity cloud

We present echelle spectrograph observations in NaD, at resolutions of 6.2-8.5 km/s, for 11 stars located in the line-of-sight to the M15 intermediate velocity cloud, which has a radial velocity of 70 km/s. This cloud is a part of IVC Complex gp. The targets range in magnitude from V=13.3-14.8. Seven of the observed stars are in the M15 globular cluster, the remaining four being field stars. Column density ratios of log(N cm^-2)=11.8-12.5 are derived. Combining the current sightlines with previously-existing data, we find the NaD/HI ratio in the IVC varies by upto a factor of 25. One cluster star, M15 ZNG-1, was also observed in Calcium. We find N(CaI)/N(CaII)<0.03 and NaI/CaII=0.25, similar to values seen in the local ISM. Finally, we detect tentative evidence for IV absorption in KI towards 3 cluster stars.Comment: A&A, in pres

Effects of molecular structure on the physical, chemical, and electrical properties of ester‐based transformer insulating liquids

This article presents the experimental studies carried out on the environmental friendly polyol ester insulating liquids to investigate the effect of molecular structure on the physical, chemical, and electrical properties. Six different polyol esters that can be produced from the transesterification of various methyl esters with neopentylglycol/trimethylolpropane alcohols were synthesized and compared with those of refined, bleached, and deodorized palm oil (RBDPO) and mineral transformer oil. The finding suggests that the physical properties like fire point, pour point, and viscosity are very much affected by the molecular weight and molecular composition of the polyol esters. The electrical properties are also highly influenced by the molecular structure‐related characteristics, such as the polarity, dipole polarization, carbon chain length, and degree of branching. The results confirm the findings of previous studies that the polyol esters and RBDPO have more polarity and dipole polarization compared to mineral oil. The experimental evidence showed that the newly synthesized insulating liquids have favorable thermal and electrical properties, thus suggesting that the insulating liquids have the potential to replace conventional insulating liquids to provide a more sustainable power system in the future

The Hepatitis B Virus Ribonuclease H Is Sensitive to Inhibitors of the Human Immunodeficiency Virus Ribonuclease H and Integrase Enzymes

Nucleos(t)ide analog therapy blocks DNA synthesis by the hepatitis B virus (HBV) reverse transcriptase and can control the infection, but treatment is life-long and has high costs and unpredictable long-term side effects. The profound suppression of HBV by the nucleos(t)ide analogs and their ability to cure some patients indicates that they can push HBV to the brink of extinction. Consequently, more patients could be cured by suppressing HBV replication further using a new drug in combination with the nucleos(t)ide analogs. The HBV ribonuclease H (RNAseH) is a logical drug target because it is the second of only two viral enzymes that are essential for viral replication, but it has not been exploited, primarily because it is very difficult to produce active enzyme. To address this difficulty, we expressed HBV genotype D and H RNAseHs in E. coli and enriched the enzymes by nickel-affinity chromatography. HBV RNAseH activity in the enriched lysates was characterized in preparation for drug screening. Twenty-one candidate HBV RNAseH inhibitors were identified using chemical structure-activity analyses based on inhibitors of the HIV RNAseH and integrase. Twelve anti-RNAseH and anti-integrase compounds inhibited the HBV RNAseH at 10 μM, the best compounds had low micromolar IC50 values against the RNAseH, and one compound inhibited HBV replication in tissue culture at 10 μM. Recombinant HBV genotype D RNAseH was more sensitive to inhibition than genotype H. This study demonstrates that recombinant HBV RNAseH suitable for low-throughput antiviral drug screening has been produced. The high percentage of compounds developed against the HIV RNAseH and integrase that were active against the HBV RNAseH indicates that the extensive drug design efforts against these HIV enzymes can guide anti-HBV RNAseH drug discovery. Finally, differential inhibition of HBV genotype D and H RNAseHs indicates that viral genetic variability will be a factor during drug development. © 2013 Tavis et al

Microbiological testing of adults hospitalised with community-acquired pneumonia: An international study

This study aimed to describe real-life microbiological testing of adults hospitalised with community-acquired pneumonia (CAP) and to assess concordance with the 2007 Infectious Diseases Society of America (IDSA)/American Thoracic Society (ATS) and 2011 European Respiratory Society (ERS) CAP guidelines. This was a cohort study based on the Global Initiative for Methicillin-resistant Staphylococcus aureus Pneumonia (GLIMP) database, which contains point-prevalence data on adults hospitalised with CAP across 54 countries during 2015. In total, 3702 patients were included. Testing was performed in 3217 patients, and included blood culture (71.1%), sputum culture (61.8%), Legionella urinary antigen test (30.1%), pneumococcal urinary antigen test (30.0%), viral testing (14.9%), acute-phase serology (8.8%), bronchoalveolar lavage culture (8.4%) and pleural fluid culture (3.2%). A pathogen was detected in 1173 (36.5%) patients. Testing attitudes varied significantly according to geography and disease severity. Testing was concordant with IDSA/ATS and ERS guidelines in 16.7% and 23.9% of patients, respectively. IDSA/ATS concordance was higher in Europe than in North America (21.5% versus 9.8%; p&lt;0.01), while ERS concordance was higher in North America than in Europe (33.5% versus 19.5%; p&lt;0.01). Testing practices of adults hospitalised with CAP varied significantly by geography and disease severity. There was a wide discordance between real-life testing practices and IDSA/ATS/ERS guideline recommendations