Attenuation of ischemic liver injury by prostaglandin E<inf>1</inf> analogue, misoprostol, and prostaglandin I<inf>2</inf> analogue, OP-41483

Background: Prostaglandin has been reported to have protective effects against liver injury. Use of this agent in clinical settings, however, is limited because of drugrelated side effects. This study investigated whether misoprostol, prostaglandin E1 analogue, and OP-41483, prostaglandin I2 analogue, which have fewer adverse effects with a longer half-life, attenuate ischemic liver damage. Study Design: Thirty beagle dogs underwent 2 hours of hepatic vascular exclusion using venovenous bypass. Misoprostol was administered intravenously for 30 minutes before ischemia and for 3 hours after reperfusion. OP-41483 was administered intraportally for 30 minutes before ischemia (2 μg/kg/min) and for 3 hours after reperfusion (0.5 μg/kg/min). Animals were divided into five groups: untreated control group (n = 10); high-dose misoprostol (total 100 μg/kg) group (MP-H, n = 5); middle-dose misoprostol (50 μg/kg) group (MP-M, n = 5); low-dose misoprostol (25 μg/kg) group (MP-L, n = 5); and OP-41483 group (OP, n = 5). Animal survival, hepatic tissue blood flow (HTBF), liver function, and histology were analyzed. Results: Two-week animal survival rates were 30% in control, 60% in MP-H, 100% in MP-M, 80% in MP-L, and 100% in OP. The treatments with prostaglandin analogues improved HTBF, and attenuated liver enzyme release, adenine nucleotrides degradation, and histologic abnormalities. In contrast to the MP-H animals that exhibited unstable cardiovascular systems, the MP- M, MP-L, and OP animals experienced only transient hypotension. Conclusions: These results indicate that misoprostol and OP-41483 prevent ischemic liver damage, although careful dose adjustment of misoprostol is required to obtain the best protection with minimal side effects

Magnetization Curves of Antiferromagnetic Heisenberg Spin-1/2 Ladders

Magnetization processes of spin-1/2 Heisenberg ladders are studied using strong-coupling expansions, numerical diagonalization of finite systems and a bosonization approach. We find that the magnetization exhibits plateaux as a function of the applied field at certain rational fractions of the saturation value. Our main focus are ladders with 3 legs where plateaux with magnetization one third of the saturation value are shown to exist.Comment: 5 pages REVTeX, 4 PostScript figures included using psfig.sty; this is the final version to appear in Phys. Rev. Let

Dilute-Bose-Gas Approach to ground state phases of 3D quantum helimagnets under high magnetic field

We study high-field phase diagram and low-energy excitations of three-dimensional quantum helimagnets. Slightly below the saturation field, the emergence of magnetic order may be mathematically viewed as Bose-Einstein condensation (BEC) of magnons. The method of dilute Bose gas enables an unbiased quantitative analysis of quantum effects in three-dimensional helimagnets and thereby three phases are found: cone, coplanar fan and an attraction-dominant one. To investigate the last phase, we extend the usual BEC approach so that we can handle 2-magnon bound states. In the case of 2-magnon BEC, the transverse magnetization vanishes and long-range order occurs in the quadrupolar channel (spin-nematic phase). As an application, we map out the phase diagram of a 3D helimagnet which consists of frustrated J1-J2 chains coupled by an interchain interaction J3.Comment: 4pages, 3figures, International Conference on Magnetism (ICM) 2009 (Karlsruhe, Germany, July 26-31, 2009)

Extended Quantum Dimer Model and novel valence-bond phases

We extend the quantum dimer model (QDM) introduced by Rokhsar and Kivelson so as to construct a concrete example of the model which exhibits the first-order phase transition between different valence-bond solids suggested recently by Batista and Trugman and look for the possibility of other exotic dimer states. We show that our model contains three exotic valence-bond phases (herringbone, checkerboard and dimer smectic) in the ground-state phase diagram and that it realizes the phase transition from the staggered valence-bond solid to the herringbone one. The checkerboard phase has four-fold rotational symmetry, while the dimer smectic, in the absence of quantum fluctuations, has massive degeneracy originating from partial ordering only in one of the two spatial directions. A resonance process involving three dimers resolves this massive degeneracy and dimer smectic gets ordered (order from disorder).Comment: 20 pages, 13 figures, accepted for publication in J. Stat. Mec

Attenuation of ischemic liver injury by monoclonal anti-endothelin antibody, awETN40

Background: Enhanced production of endothelin-1 (ET1), vasoconstrictive 21 amino acids produced by endothelial cells during ischemia and after reperfusion of the liver, is known to cause sinusoidal constriction and microcirculatory disturbances, which lead to severe tissue damage. Using a 2- hour hepatic vascular exclusion model in dogs, we tested our hypothesis that neutralization of ET-1 by monoclonal anti-ET-1 and anti-ET-2 antibody (AwETN40) abates vascular dysfunction and ameliorates ischemia/reperfusion injury of the liver. Study Design: After skeletonization, the liver was made totally ischemic by cross-clamping the portal vein, the hepatic artery, and the vena cava (above and below the liver). Venovenous bypass was used to decompress splanchnic and inferior systemic congestion. AwETN40, 5 mg/kg, was administered intravenously 10 minutes before ischemia (treatment group, n = 5). Nontreated animals were used as controls (control group, n = 10). Animal survival, hepatic tissue blood flow, liver function tests; total bile acid, high-energy phosphate, ET-1 levels, and liver histopathology were studied. Results: Treatment with AwETN40 improved 2-week animal survival from 30% to 100%. Hepatic tissue blood flow after reperfusion was significantly higher in the treatment group. The treatment significantly attenuated liver enzyme release, total bile acid, and changes in adenine nucleotides. Immunoreactive ET-1 levels in the hepatic venous blood of the control group showed a significant increase and remained high for up to 24 hours after reperfusion. Histopathologic alterations were significantly lessened in the treatment group. Conclusions: These results indicate that ET-1 is involved in ischemia/reperfusion injury of the liver, which can be ameliorated by the monoclonal anti-ET-1 and antiET-2 antibody AwETN40

Magnetization plateau in the S=1/2 spin ladder with alternating rung exchange

We have studied the ground state phase diagram of a spin ladder with alternating rung exchange $J^{n}_{\perp} = J_{\perp}[1 + (-1)^{n} \delta ]$ in a magnetic filed, in the limit where the rung coupling is dominant. In this limit the model is mapped onto an $XXZ$ Heisenberg chain in a uniform and staggered longitudinal magnetic fields, where the amplitude of the staggered field is $\sim \delta$. We have shown that the magnetization curve of the system exhibits a plateau at magnetization equal to the half of the saturation value. The width of a plateau scales as $\delta^{\nu}$, where $\nu =4/5$ in the case of ladder with isotropic antiferromagnetic legs and $\nu =2$ in the case of ladder with isotropic ferromagnetic legs. We have calculated four critical fields ($H^{\pm}_{c1}$ and $H^{\pm}_{c2}$) corresponding to transitions between different magnetic phases of the system. We have shown that these transitions belong to the universality class of the commensurate-incommensurate transition.Comment: 6 pages, 2 figure

Massive and Massless Behavior in Dimerized Spin Ladders

We investigate the conditions under which a gap vanishes in the spectrum of dimerized coupled spin-1/2 chains by means of Abelian bosonization and Lanczos diagonalization techniques. Although both interchain ($J'$) and dimerization ($\delta$) couplings favor a gapful phase, it is shown that a suitable choice of these interactions yields massless spin excitations. We also discuss the influence of different arrays of relative dimerization on the appearance of non-trivial magnetization plateaus.Comment: 5 pages, RevTex, 5 Postscript figure

Ground-state phase diagram and magnetic properties of a tetramerized spin-1/2 J_1-J_2 model: BEC of bound magnons and absence of the transverse magnetization

We study the ground state and the magnetization process of a spin-1/2 $J_1$-$J_2$ model with a plaquette structure by using various methods. For small inter-plaquette interaction, this model is expected to have a spin-gap and we computed the first- and the second excitation energies. If the gap of the lowest excitation closes, the corresponding particle condenses to form magnetic orders. By analyzing the quintet gap and magnetic interactions among the quintet excitations, we find a spin-nematic phase around $J_1/J_2\sim -2$ due to the strong frustration and the quantum effect. When high magnetic moment is applied, not the spin-1 excitations but the spin-2 ones soften and dictate the magnetization process. We apply a mean-field approximation to the effective Hamiltonian to find three different types of phases (a conventional BEC phase, ``striped'' supersolid phases and a 1/2-plateau). Unlike the BEC in spin-dimer systems, this BEC phase is not accompanied by transverse magnetization. Possible connection to the recently discovered spin-gap compound (CuCl)LaNb2O7 is discussed.Comment: 18pages, 17figures; title changed, typos correcte

The solar neutrino problem after three hundred days of data at SuperKamiokande

We present an updated analysis of the solar neutrino problem in terms of both Mikheyev-Smirnov-Wolfenstein (MSW) and vacuum neutrino oscillations, with the inclusion of the preliminary data collected by the SuperKamiokande experiment during 306.3 days of operation. In particular, the observed energy spectrum of the recoil electrons from 8B neutrino scattering is discussed in detail and is used to constrain the mass-mixing parameter space. It is shown that: 1) the small mixing MSW solution is preferred over the large mixing one; 2) the vacuum oscillation solutions are strongly constrained by the energy spectrum measurement; and 3) the detection of a possible semiannual modulation of the 8B \nu flux due to vacuum oscillations should require at least one more year of operation of SuperKamiokande.Comment: 15 pages (RevTeX) + 8 figures (postscript). Requires epsfig.st

A new family of models with exact ground states connecting smoothly the S=1/2 dimer and S=1 Haldane phases of 1D spin chains

We investigate the isotropic two-leg S=1/2 ladder with general bilinear and biquadratic exchange interactions between spins on neighboring rungs, and determine the Hamiltonians which have a matrix product wavefunction as exact ground state. We demonstrate that a smooth change of parameters leads one from the S=1/2 dimer and Majumdar-Ghosh chains to the S=1 chain with biquadratic exchange. This proves that these model systems are in the same phase. We also present a new set of models of frustrated S=1/2 spin chains (including only bilinear NN and NNN interactions) whose ground states can be found exactly.Comment: 4 pages, RevTeX, uses psfig.sty, submitted to Phys. Rev. Let