The Application of a Decision-making Approach based on Fuzzy ANP and TOPSIS for Selecting a Strategic Supplier

Supplier selection becomes very important when used in the context of strategic partnerships because of the long-term orientation of the relationship. This paper describes the application of a decision-making approach for selecting a strategic partner (supplier). The approach starts with defining a set of criteria that fits the company's condition. In the next steps, a combination of fuzzy-ANP and TOPSIS methods is used to determine the weight for each criterion and rank all the alternatives. The application of the approach in an Indonesian manufacturing company showed that the three factors that got the highest weight were "geographical location", "current operating performance", and "reliability". Geographical location got the highest weight because it affects many other factors such as reaction to changes in demand, after-sales service, and delivery lead-time.  Application of the approach helps decision-makers to gain effectiveness and efficiency in the decision-making process because it facilitates them to express their group's collective preferences  while also providing opportunities for members to express their individual preferences. Future research can be directed at combining qualitative and quantitative criteria to develop the best criteria and methods for the selection of the best suppliers based on fuzzy ANP and TOPSIS

Hubungan Karakteristik dengan Partisipasi Masyarakat dalam Pengelolaan Sampah di Lingkungan III dan V Kelurahan Bagan Deli Kecamatan Medan Belawan Tahun 2012

Relationship of Responden Characteristics (Education, Income, Occupation Knowledge and Attitude) And The Management Of Solid Waste Management Program In Area III and V Bagan Deli, Medan Belawan sub-district. Solid waste management program is one of the programs of Ministry of Sea and Fishery in Medan Belawan sub-district. On its implementation, solid waste management program in area III and V yet done well. Lack of the participation of the society on solid waste management may be caused by less understanding on sorting out the rubbish of household. The objective of this research is to analyze the relationship of responden characteristics (education, income, occupation knowledge and attitude) and the management of solid waste management program in area III and V Bagan Deli, Medan Belawan sub-district. This research was analytical survey with cross sectional design. The population was the housewives living in area III and V Bagan Deli, Medan Belawan sub-district for 631 persons, and the sample was taken for 87 persons. The data of the characteristics (education, income occupation, knowledge and attitude), management program, and the participation of the people was taken through direct interview using questionnaire. The collected data then analyzed using chi-square test at α = 0,05.The resulth of research showed that statistically the characteristics include education (p-value = 0,028), occupation status (p-value= 0,000). Knowledge level (p-value=0,002), and attitude (p-value=0,000) has significant relationship not have significant influence to the participation of the society. It si suggested for the management program parties to improve socialization about solid waste management program in rder to get better understanding on the rubbish and to improve the participation of the people

The Application of a Decision-making Approach Based on Fuzzy ANP and TOPSIS for Selecting a Strategic Supplier

Supplier selection becomes very important when used in the context of strategic partnerships because of the long-term orientation of the relationship. This paper describes the application of a decision-making approach for selecting a strategic partner (supplier). The approach starts with defining a set of criteria that fits the company's condition. In the next steps, a combination of fuzzy-ANP and TOPSIS methods is used to determine the weight for each criterion and rank all the alternatives. The application of the approach in an Indonesian manufacturing company showed that the three factors that got the highest weight were “geographical location”, “current operating performance”, and “reliability”. Geographical location got the highest weight because it affects many other factors such as reaction to changes in demand, after-sales service, and delivery lead-time. Application of the approach helps decision-makers to gain effectiveness and efficiency in the decision-making process because it facilitates them to express their group's collective preferences while also providing opportunities for members to express their individual preferences. Future research can be directed at combining qualitative and quantitative criteria to develop the best criteria and methods for the selection of the best suppliers based on fuzzy ANP and TOPSIS

The scientist' experience in participated science communication

Since 2006 a small group of researchers from the Italian National Institute for Nuclear Physics started to realized one of the first European Researchers' Night in Europe: a one night-event, supported by the European Commission, that falls every last Friday of September to promote the researcher's figure and its work. Today, after thirteen editions, the project has evolved by involving more than 60 scientific partners and more than 400 events/year spread from the North to the South of Italy in 30 cities, captivating more than 50.000 attendees with a not negligible impact on the people and the press. During the years, the project has followed and sometimes anticipated the science communication trend, and BEES (BE a citizEn Scientist) is the last step of this long and thrilling evolution that brought to a huge public engagement in our territory. The experience, the methodology, and the major successful examples of the organized events are presented together with the results of the long term project impact

Behavior of a frustrated quantum spin chain with bond dimerization

We clarified behavior of the excitation gap in a frustrated S=1/2 quantum spin chain with bond dimerization by using the numerical diagonalization of finite systems and a variational approach. The model interpolates between the independent dimer model and the S=1 spin chain by changing a strength of the dimerization. The energy gap is minimum at the fully-frustrated point, where a localized kink and a freely mobile anti-kink govern the low-lying excitations. Away from the point, a kink and an antikink form a bound state by an effective triangular potential between them. The consequential gap enhancement and the localization length of the bound state is obtained exactly in the continuous limit. The gap enhancement obeys a power law with exponent 2/3. The method and the obtained results are common to other frustrated double spin-chain systems, such as the one-dimensional J_1 - J_2 model, or the frustrated ladder model.Comment: 11 pages, REVTeX, 8 figures in eps-fil

IRF4 expression is low in Philadelphia negative myeloproliferative neoplasms and is associated with a worse prognosis

Interferon regulatory factor 4 (IRF4) is involved in the pathogenesis of various hematologic malignancies. Its expression has been related to the negative regulation of myeloid-derived suppressor cells (MDSCs) and the polarization of anti-inflammatory M2 macrophages, thereby altering immunosurveillance and inflammatory mechanisms. An abnormal inflammatory status in the bone marrow microenvironment of myeloproliferative neoplasms (MPNs) has recently been demonstrated; moreover, in chronic myeloid leukemia a downregulated expression of IRF4 has been found. In this context, we evaluated the IRF4 expression in 119 newly diagnosed consecutive Philadelphia negative MPNs (Ph- MPNs), showing a low expression among the MPNs phenotypes with a more significant decrease in primary myelofibrosis patients. Lower IRF4 levels were associated with JAK2 + and triple negatives cases carrying the worst prognosis. Furthermore, the IRF4 levels were related to leukemic transformation and a shorter leukemia-free survival; moreover, the risk of myelofibrosis transformation in polycythemia vera and essential thrombocythemia patients was more frequent in cases with lower IRF4 levels. Overall, our study demonstrates an IRF4 dysregulated expression in MPNs patients and its association with a worse prognosis. Further studies could validate these data, to improve our knowledge of the MPNs pathogenesis and confirm the IRF4 role as a new prognostic factor

RUNX1 gene alterations characterized by allelic preference in adult acute myeloid leukemia

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Nanopore sequencing approach for immunoglobulin gene analysis in chronic lymphocytic leukemia

The evaluation of the somatic hypermutation of the clonotypic immunoglobulin heavy variable gene has become essential in the therapeutic management in chronic lymphocytic leukemia patients. European Research Initiative on Chronic Lymphocytic Leukemia promotes good practices and standardized approaches to this assay but often they are labor-intensive, technically complex, with limited in scalability. The use of next-generation sequencing in this analysis has been widely tested, showing comparable accuracy and distinct advantages. However, the adoption of the next generation sequencing requires a high sample number (run batching) to be economically convenient, which could lead to a longer turnaround time. Here we present data from nanopore sequencing for the somatic hypermutation evaluation compared to the standard method. Our results show that nanopore sequencing is suitable for immunoglobulin heavy variable gene mutational analysis in terms of sensitivity, accuracy, simplicity of analysis and is less time-consuming. Moreover, our work showed that the development of an appropriate data analysis pipeline could lower the nanopore sequencing error rate attitude

A Simplified Equation for Calculating the Water Quality Index (WQI), Kalu River, Sri Lanka

The water supply system plays a major role in the community. The water source is carefully selected based on quality, quantity, and reliability. The quality of water at its sources is continuously deteriorating due to various anthropogenic activities and is a major concern to public health as well. The Kalu River is one of the major water resources in Sri Lanka that supplies potable water to the Kalutara district (a highly populated area) and Rathnapura district. But, there has been no significant research or investigation to examine anthropogenic activities in the river. Due to this, it is difficult to find any proper study related to the overall water quality in the Kalu River. Therefore, this study covers a crucial part related to the water quality of the Kalu River. The spatiotemporal variation of river water quality is highly important not only to processing any treatment activities but also to implementing policy decisions. In this context, water quality management is a global concern as countries strive to meet the United Nations Sustainable Development Goal 6, which aims to ensure the availability and sustainable management of water and sanitation for all. Poor water quality can have severe consequences on human health, ecosystems, and economies. Contaminated water sources pose risks of waterborne diseases, reduced agricultural productivity, and ecological imbalances. Hence, assessing and improving water quality is crucial for achieving sustainable development worldwide. Therefore, this paper presents a comprehensive analysis of spatiotemporal analysis of the water quality of the Kalu River using the water quality data of eight locations for 6 years from 2017 to 2023. Nine water quality parameters, including the pH, electrical conductivity, temperature, chemical oxygen demand, biological oxygen demand, total nitrate, total phosphate, total sulfate, total chlorine, and hardness, were used to develop a simple equation to investigate the water quality index (WQI) of the river. Higher WQI values were not recorded near the famous Kalutara Bridge throughout the years, even though the area is highly urbanized and toured due to religious importance. Overall, the water quality of the river can be considered acceptable based on the results of the WQI. The country lockdowns due to COVID-19 might have impacted the results in 2020; this can be clearly seen with the variation of the annual WQI average, as it clearly indicates decreased levels of the WQI in the years 2020 and 2021, and again, the rise of the WQI level in 2022, as this time period corresponds to the lockdown season and relaxation of the lockdown season in the country. Somehow, for most cases in the Kalu River, the WQI level is well below 25, which can be considered acceptable and suitable for human purposes. But, it may need some attention towards the areas to find possible reasons that are not in the range. Nevertheless, the results suggest the importance of continuous water quality monitoring in the Kalu River