Two-sided radio emission in ON231 (W Comae)

Recent radio images of the BL Lac object ON231 (W Com, 1219+285) show remarkable new features in the source structure compared to those previously published. The images were obtained from observations made with the European VLBI Network plus MERLIN at 1.6 GHz and 5 GHz after the exceptional optical outburst occurred in Spring 1998. The up-to-date B band historic light curve of ON231 is also presented together with the R band luminosity evolution in the period 1994--1999. We identify the source core in the radio images with the brightest component having the flattest spectrum. A consequence of this assumption is the existence of a two--sided emission in ON231 not detected in previous VLBI images. A further new feature is a large bend in the jet at about 10 mas from the core. The emission extends for about 20 mas after the bend, which might be due to strong interaction with the environment surrounding the nucleus. We suggest some possible interpretations to relate the changes in the source structure with the optical and radio flux density variation in the frame of the unification model.Comment: 8 pages, 8 figure

Development of the opto-mechanical design for ICE-T

ICE-T (International Concordia Explorer Telescope) is a double 60 cm f/1.1 photometric robotic telescope, on a parallactic mount, which will operate at Dome C, in the long Antarctic night, aiming to investigate exoplanets and activity of the hosting stars. Antarctic Plateau site is well known to be one of the best in the world for observations because of sky transparency in all wavelengths and low scintillation noise. Due to the extremely harsh environmental conditions (the lowest average temperature is -80$^\circ$C) the criteria adopted for an optimal design are really challenging. Here we present the strategies we have adopted so far to fulfill the mechanical and optical requirements.Comment: 7 pages, 2 figures, contributed talk at 'An astronomical Observatory at Concordia (Dome C, Antarctica) for the next decade', 11-15 May, Rome (Italy

Mid Infrared Photometry of Mass-Losing AGB Stars

We present ground-based mid-infrared imaging for 27 M-, S- and C-type Asymptotic Giant Branch (AGB) stars. The data are compared with those of the database available thanks to the IRAS, ISO, MSX and 2MASS catalogues. Our goal is to establish relations between the IR colors, the effective temperature $T_{eff}$, the luminosity $L$ and the mass loss rate $\dot M$, for improving the effectiveness of AGB modelling. Bolometric (absolute) magnitudes are obtained through distance compilations, and by applying previously-derived bolometric corrections; the variability is also studied, using data accumulated since the IRAS epoch. The main results are: i) Values of $L$ and $\dot M$ for C stars fit relations previously established by us, with Miras being on average more evolved and mass losing than Semiregulars. ii) Moderate IR excesses (as compared to evolutionary tracks) are found for S and M stars in our sample: they are confirmed to originate from the dusty circumstellar environment. iii) A larger reddening characterizes C-rich Miras and post-AGBs. In this case, part of the excess is due to AGB models overestimating $T_{eff}$ for C-stars, as a consequence of the lack of suitable molecular opacities. This has a large effect on the colors of C-rich sources and sometimes disentangling the photospheric and circumstellar contributions is difficult; better model atmospheres should be used in stellar evolutionary codes for C stars. iv) The presence of a long-term variability at mid-IR wavelengths seems to be limited to sources with maximum emission in the 8 -- 20 $\mu$m region, usually Mira variables (1/3 of our sample). Most Semiregular and post-AGB stars studied here remained remarkably constant in mid-IR over the last twenty years.Comment: Accepted for publication in the Astronomical Journal - 35 pages (in preprint), 9 figures, 5 table

The Gattini cameras for optical sky brightness measurements at Dome C, Antarctica

The Gattini cameras are two site testing instruments for the measurement of optical sky brightness, large area cloud cover and auroral detection of the night sky above the high altitude Dome C site in Antarctica. The cameras have been operating since installation in January 2006 and are currently at the end of the first Antarctic winter season. The cameras are transit in nature and are virtually identical both adopting Apogee Alta CCD detectors. By taking frequent images of the night sky we obtain long term cloud cover statistics, measure the sky background intensity as a function of solar and lunar altitude and phase and directly measure the spatial extent of bright aurora if present and when they occur. The full data set will return in December 2006 however a limited amount of data has been transferred via the Iridium network enabling preliminary data reduction and system evaluation. An update of the project is presented together with preliminary results from data taken since commencement of the winter season

Emerging Multidrug Resistance of Methicillin-Resistant Staphylococcus aureus in Hand Infections.

BACKGROUND: Methicillin-resistant Staphylococcus aureus has been the most commonly identified pathogen in hand infections at urban centers, but the evolving antibiotic sensitivity profiles of methicillin-resistant Staphylococcus aureus are not known. The purposes of this study are to determine if multidrug resistance in methicillin-resistant Staphylococcus aureus is emerging and to provide current recommendations for empiric antibiotic selection for hand infections in endemic regions. METHODS: An eight-year longitudinal, retrospective chart review was performed on all culture-positive hand infections encountered by an urban hospital from 2005 to 2012. The proportions of all major organisms were calculated for each year. Methicillin-resistant Staphylococcus aureus infections were additionally analyzed for antibiotic sensitivity. RESULTS: A total of 683 culture-positive hand infections were identified. Overall, methicillin-resistant Staphylococcus aureus grew on culture in 49% of cases; the annual incidence peaked at 65% in 2007. Over the study period, methicillin-resistant Staphylococcus aureus was universally resistant to penicillin, oxacillin, and ampicillin. Clindamycin resistance significantly increased, approaching 20% by 2012 (p = 0.02). Levofloxacin resistance linearly increased from 12% to 50% (p \u3c 0.01). Resistance to trimethoprim-sulfamethoxazole, tetracycline, gentamicin, and moxifloxacin was only sporadically observed. Resistance to vancomycin, daptomycin, linezolid, and rifampin was not observed. CONCLUSIONS: Significant increases in resistance to clindamycin and levofloxacin were observed in recent years, and empiric therapy with these drugs may have limited efficacy, especially in urban centers. CLINICAL RELEVANCE: Hand infections caused by methicillin-resistant Staphylococcus aureus may be developing increasing resistance to clindamycin and levofloxacin in recent years. This longitudinal study examines the effectiveness of a variety of antibiotics to methicillin-resistant Staphylococcus aureus

Status and Plans for the Array Control and Data Acquisition System of the Cherenkov Telescope Array

The Cherenkov Telescope Array (CTA) is the next-generation atmospheric Cherenkov gamma-ray observatory. CTA will consist of two installations, one in the northern, and the other in the southern hemisphere, containing tens of telescopes of different sizes. The CTA performance requirements and the inherent complexity associated with the operation, control and monitoring of such a large distributed multi-telescope array leads to new challenges in the field of the gamma-ray astronomy. The ACTL (array control and data acquisition) system will consist of the hardware and software that is necessary to control and monitor the CTA arrays, as well as to time-stamp, read-out, filter and store -at aggregated rates of few GB/s- the scientific data. The ACTL system must be flexible enough to permit the simultaneous automatic operation of multiple sub-arrays of telescopes with a minimum personnel effort on site. One of the challenges of the system is to provide a reliable integration of the control of a large and heterogeneous set of devices. Moreover, the system is required to be ready to adapt the observation schedule, on timescales of a few tens of seconds, to account for changing environmental conditions or to prioritize incoming scientific alerts from time-critical transient phenomena such as gamma ray bursts. This contribution provides a summary of the main design choices and plans for building the ACTL system.Comment: In Proceedings of the 34th International Cosmic Ray Conference (ICRC2015), The Hague, The Netherlands. All CTA contributions at arXiv:1508.0589

Lipidomics Provides New Insight into Pathogenesis and Therapeutic Targets of the Ischemia-Reperfusion Injury

Lipids play an essential role in both tissue protection and damage. Tissue ischemia creates anaerobic conditions in which enzyme inactivation occurs, and reperfusion can initiate oxidative stress that leads to harmful changes in membrane lipids, the formation of aldehydes, and chain damage until cell death. The critical event in such a series of harmful events in the cell is the unwanted accumulation of fatty acids that leads to lipotoxicity. Lipid analysis provides additional insight into the pathogenesis of ischemia/reperfusion (I/R) disorders and reveals new targets for drug action. The profile of changes in the composition of fatty acids in the cell, as well as the time course of these changes, indicate both the mechanism of damage and new therapeutic possibilities. A therapeutic approach to reperfusion lipotoxicity involves attenuation of fatty acids overload, i.e., their transport to adipose tissue and/or inhibition of the adverse effects of fatty acids on cell damage and death. The latter option involves using PPAR agonists and drugs that modulate the transport of fatty acids via carnitine into the interior of the mitochondria or the redirection of long-chain fatty acids to peroxisomes