Resting-state connectivity and functional specialization in human medial parieto-occipital cortex

According to recent models of visuo-spatial processing, the medial parieto-occipital cortex is a crucial node of the dorsal visual stream. Evidence from neurophysiological studies in monkeys has indicated that the parieto-occipital sulcus (POS) contains three functionally and cytoarchitectonically distinct areas: the visual area V6 in the fundus of the POS, and the visuo-motor areas V6Av and V6Ad in a progressively dorsal and anterior location with respect to V6. Besides different topographical organization, cytoarchitectonics, and functional properties, these three monkey areas can also be distinguished based on their patterns of cortico-cortical connections. Thanks to wide-field retinotopic mapping, areas V6 and V6Av have been also mapped in the human brain. Here, using a combined approach of resting-state functional connectivity and task-evoked activity by fMRI, we identified a new region in the anterior POS showing a pattern of functional properties and cortical connections that suggests a homology with the monkey area V6Ad. In addition, we observed distinct patterns of cortical connections associated with the human V6 and V6Av which are remarkably consistent with those showed by the anatomical tracing studies in the corresponding monkey areas. Consistent with recent models on visuo-spatial processing, our findings demonstrate a gradient of functional specialization and cortical connections within the human POS, with more posterior regions primarily dedicated to the analysis of visual attributes useful for spatial navigation and more anterior regions primarily dedicated to analyses of spatial information relevant for goal-directed action

Signals of sustainability transition: Sensing enabling factors through cultural initiatives

This article reports a first attempt to combine the analysis of socio-technical mechanisms and initiative-based learning to sense sustainability transition signals in cities. Relying on the analysis of cultural initiatives in six European Cities, the study identifies those factors that enabled social impact generation. It then formulates hypotheses about their contribution to the inception and rooting of sustainability transition dynamics. As a result, the article proposes a set of analytical categories of enabling factors acting across niches and regimes. The same factors are then reinterpreted by referring to scaling mechanisms (scaling up, out and deep). The proposed analytical scheme seeks to offer a broader reflection on the conceptual and methodological challenges related to sensing and interpreting urban sustainability transition pathways

Innovation Capacity and the City. The Enabling Role of Design

This open access book makes up one of the key milestones of the DESIGNSCAPES project, a H2020 CSA (Coordination and Support Action) research project funded by the European Commission under the Call “User-driven innovation: value creation through design-enabled innovation. It shows that adopting Design enables to embed Innovation within the City in order to conceptualize feasible answers to complex global challenges. By so doing, innovation can become disruptive for the values it brings while at the same time igniting dynamics of gradual change in the "urbanscape" it acts within. To explore this potential, the concept is developed of “Design enabled Innovation in urban environments” looking at the role that the City can play in promoting and facilitating the adoption of Design by public and private sector innovators. This leads to a possible evaluation framework whereby an urbanscape is considered with respect to both its innovation generation capacity and to the nature (more or less Design dependent, or prone) of the innovative initiatives it hosts. This thread of reasoning has many promising implications, including the proposal of a "third way" between the dreamers of an alternative economic model where revenues and growth are sacrificed on the altar of social and environmental respect, and the supporters of traditional market based view, who think it is enough to add a touch of responsibility and concern to a system that should continue rewarding the profitability of innovations

From Crystalline to Amorphous Germania Bilayer Films at the Atomic Scale: Preparation and Characterization

A new two-dimensional (2D) germanium dioxide film has been prepared. The film consists of interconnected germania tetrahedral units forming a bilayer structure, weakly coupled to the supporting Pt(111) metal-substrate. Density functional theory calculations predict a stable structure of 558-membered rings for germania films, while for silica films 6-membered rings are preferred. By varying the preparation conditions the degree of order in the germania films is tuned. Crystalline, intermediate ordered and purely amorphous film structures are resolved by analysing scanning tunnelling microscopy images

Concreteness and emotional valence of episodic future thinking (EFT) independently affect the dynamics of intertemporal decisions

During intertemporal decisions, the value of future rewards decreases as a function of the delay of its receipt (temporal discounting, TD). Since high discount rates have been associated with a series of problematic behaviours and clinical conditions, current research has focused on possible modulators of TD. Specifically, a reduction of individual discount rates has been shown during episodic future thinking (EFT), wherein time intervals are anchored to personal future events. However, it is not entirely clear whether this effect is mediated by a change in the representation of future events (i.e., from abstract to concrete) or by a positive-emotion modulation. Here, we investigated this issue by manipulating the valence of the EFT (i.e., using negative, neutral and positive episodic tags), and by collecting explicit and implicit measures of behaviour. The results showed a significant reduction of TD in all the three emotional conditions compared to the baseline, with differences among them, thus suggesting the existence of a cumulative effect of the concreteness and affective components of the EFT. The analyses of implicit measures additionally revealed that this effect was mediated by a simultaneous increase/decrease of attraction toward the delayed/immediate alternative. Finally, these effects appeared to be modulated by participants' baseline discounting preferences. These findings provide important insights on clinical applications in reward-related disorders

Going About the City: Methods and Methodologies for Urban Communication Research

This introduction to the special section on methods and methodologies for urban communication research discusses major approaches to conceptualizing and researching the relationship between cities and communication. We underline the increasing significance of scholarship on the various ways in which city dwellers relate to each other and their urban environment through symbolic, technological, and material means. We then argue that a systematic conversation on the methodological principles, protocols, and practices that set apart this burgeoning area of inquiry is not only timely, but also much needed. With this objective in mind, we invited a group of scholars to reflect on the key questions, instruments, challenges, and contributions of documentary, audiencing, material, visual, mixed-method, ecological, and applied perspectives on urban communication. Based on the seven articles included in the special section, we propose three distinct but interrelated conceptual heuristics—the city as context, the city as medium, the city as content—that highlight the importance of cities as both producers and products of particular practices, interactions, and narratives. We finally conclude that, vis-à-vis research on the automatic production of urban space, urban communication scholarship may contribute to strengthening a broader research agenda rooted in an understanding of communication as a human endeavor

Interindividual variability in functional connectivity as long-term correlate of temporal discounting

During intertemporal choice (IT) future outcomes are usually devaluated as a function of the delay, a phenomenon known as temporal discounting (TD). Based on task-evoked activity, previous neuroimaging studies have described several networks associated with TD. However, given its relevance for several disorders, a critical challenge is to define a specific neural marker able to predict TD independently of task execution. To this aim, we used restingstate functional connectivity MRI (fcMRI) and measured TD during economic choices several months apart in 25 human subjects.We further explored the relationship between TD, impulsivity and decision uncertainty by collecting standard questionnaires on individual trait/ state differences. Our findings indicate that fcMRI within and between critical nodes of taskevoked neural networks associated with TD correlates with discounting behavior measured a long time afterwards, independently of impulsivity. Importantly, the nodes form an intrinsic circuit that might support all the mechanisms underlying TD, from the representation of subjective value to choice selection through modulatory effects of cognitive control and episodic prospection

From Crystalline to Amorphous Germania Bilayer Films at the Atomic Scale: Preparation and Characterization

A new two-dimensional (2D) germanium dioxide film has been prepared. The film consists of interconnected germania tetrahedral units forming a bilayer structure, weakly coupled to the supporting Pt(111) metal-substrate. Density functional theory calculations predict a stable structure of 558-membered rings for germania films, while for silica films 6-membered rings are preferred. By varying the preparation conditions the degree of order in the germania films is tuned. Crystalline, intermediate ordered and purely amorphous film structures are resolved by analysing scanning tunnelling microscopy images

I soffi carotidei asintomatici scoperti in corso di bilancio preoperatorio. Condotta diagnostica e terapeutica.

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