188 research outputs found
Scalar Transfer across a Turbulent/non-turbulent Interface in a Planar Jet
This fluid dynamics video is an entry for the Gallery of Fluid Motion of the
66th Annual Meeting of the APS-DFD. In this video, the scalar transfer across
the turbulent/non-turbulent (T/NT) interface in a planar jet is investigated by
using a direct numerical simulation. Visualization of the scalar flux across
the T/NT interface shows that the diffusive species premixed in the ambient
flow is transferred into the turbulent region mainly across the leading edge
(Here, the leading edge is the T/NT interface across which the turbulent fluid
turns into the non-turbulent fluid in the streamwise direction).Comment: The fluid dynamics video for an entry for the Gallery of Fluid Motion
of the 66th Annual Meeting of the APS-DFD is include
Direct Numerical Simulation of Turbulence with Scalar Transfer around Complex Geometries Using the Immersed Boundary Method and Fully Conservative Higher-Order Finite-Difference Schemes
Contribution of acidic extracellular microenvironment of cancer-colonized bone to bone pain
Solid and hematologic cancer colonized bone produces a number of pathologies. One of the most common complications is bone pain. Cancer-associated bone pain (CABP) is a major cause of increased morbidity and diminishes the quality of life and affects survival. Current treatments do not satisfactorily control CABP and can elicit adverse effects. Thus, new therapeutic interventions are needed to manage CABP. However, the mechanisms responsible for CABP are poorly understood. The observation that specific osteoclast inhibitors can reduce CABP in patients indicates a critical role of osteoclasts in the pathophysiology of CABP. Osteoclasts create an acidic extracellular microenvironment by secretion of protons via vacuolar proton pumps during bone resorption. In addition, bone-colonized cancer cells also release protons and lactate via plasma membrane pH regulators to avoid intracellular acidification resulting from increased aerobic glycolysis known as the Warburg effect. Since acidosis is algogenic for sensory neurons and bone is densely innervated by sensory neurons that express acid-sensing nociceptors, the acidic bone microenvironments can evoke CABP. Understanding of the mechanism by which the acidic extracellular microenvironment is created in cancer-colonized bone and the expression and function of the acid-sensing nociceptors are regulated should facilitate the development of novel approaches for management of CABP. Here, the contribution of the acidic microenvironment created in cancer-colonized bone to elicitation of CABP and potential therapeutic implications of blocking the development and recognition of acidic microenvironment will be described. This article is part of a Special Issue entitled: Membrane channels and transporters in cancers
EFFECTS OF SCATTER IN BOLT PRELOAD ON THE SEALING PERFORMANCE IN BOLTED FLANGE CONNECTIONS WITH COVER OF PRESSURE VESSEL UNDER INTERNAL PRESSURE
ABSTRACT It has been well known that the scatter in axial bolt forces of bolted flange connections tightened by torque control methods is substantial. In evaluating the sealing performance of a bolted flange connection with a gasket subjected to internal pressure, it is necessary to know the contact gasket stress distributions due to the scatter of the axial bolt forces in the flange connections tightened by torque control methods. This paper deals with the leakage of a bolted flange connection with a cover of pressure vessel including a spiral wound gasket tightened by a torque wrench. The scatter in the axial bolt forces was measured using strain gauges attached at the shank of bolts. The amount of leakage from the bolted flange connection with cover of pressure vessel was measured by socalled pressure decay method. The gas employed was Helium. From the measured leakage, the actual assembly efficiency is examined. The eight bolts and nuts were tightened according to the ASME PCC-1 method and Japanese method developed by High Pressure Institute (HPI). The difference in the bolt preload was shown between the ASME method and the HPI method. The contact gasket stress distributions at the interface of the flange connection with the gasket were calculated under the measured axial bolt forces by means of finite element analysis. Using the calculated gasket contact stress distribution, the amount of gas leakage was estimated. The estimated gas leakage was compared with the measured results
Metal Ion Homeostasis Mediated by NRAMP Transporters in Plant Cells - Focused on Increased Resistance to Iron and Cadmium Ion
Antiresorptive agent-related osteonecrosis of the jaw: Position Paper 2017 of the Japanese Allied Committee on Osteonecrosis of the Jaw
Antiresorptive agent-related osteonecrosis of the jaw (ARONJ) is an intractable, though rare, complication in cancer patients with bone metastases and patients with osteoporosis who are treated with antiresorptive agents, including bisphosphonates and denosumab. Despite the more than 10 years that have passed since the first cases of bisphosphonate-related osteonecrosis of the jaw (BRONJ) were reported, our understanding of the epidemiology and pathophysiology of ARONJ remains limited, and data supported by evidence-based medicine are still sparse. However, the diagnosis and staging of ARONJ, identification of risk factors, and development of preventive and therapeutic approaches have advanced significantly over the past decade. The Position Paper 2017 is an updated version of the Position Paper 2010 of the Japanese Allied Committee on Osteonecrosis of the Jaw, which now comprises six Japanese academic societies. The Position Paper 2017 describes a new diagnostic definition for ARONJ, as proposed by the American Association of Oral and Maxillofacial Surgeons (AAOMS), summarizes our current understanding of the pathophysiology of ARONJ based on a literature search, and suggests methods for physicians and dentists/oral surgeons to manage the disease. In addition, the appropriateness of discontinuing antiresorptive medications (drug holiday) before, during, and after invasive dental treatments is discussed extensively. More importantly, the manuscript also proposes, for the first time, the importance of interactive communication and cooperation between physicians and dentists/oral surgeons for the successful treatment of ARONJ. The Position Paper 2017 is intended to serve as a guide for improving the management of ARONJ patients in Japan
Zika virus infection in pregnancy: a systematic review of disease course and complications
OBJECTIVES: To characterize maternal Zika virus (ZIKV) infection
and complement the evidence base for the WHO interim guidance on
pregnancy management in the context of ZIKV infection. METHODS:
We searched the relevant database from inception until March
2016. Two review authors independently screened and assessed
full texts of eligible reports and extracted data from relevant
studies. The quality of studies was assessed using the
Newcastle-Ottawa Scale (NOS) and the National Institute of
Health (NIH) tool for observational studies and case
series/reports, respectively. RESULTS: Among 142 eligible
full-text articles, 18 met the inclusion criteria (13 case
series/reports and five cohort studies). Common symptoms among
pregnant women with suspected/confirmed ZIKV infection were
fever, rash, and arthralgia. One case of Guillain-Barre syndrome
was reported among ZIKV-infected mothers, no other case of
severe maternal morbidity or mortality reported. Complications
reported in association with maternal ZIKV infection included a
broad range of fetal and newborn neurological and ocular
abnormalities; fetal growth restriction, stillbirth, and
perinatal death. Microcephaly was the primary neurological
complication reported in eight studies, with an incidence of
about 1% among newborns of ZIKV infected women in one study.
CONCLUSION: Given the extensive and variable fetal and newborn
presentations/complications associated with prenatal ZIKV
infection, and the dearth of information provided, knowledge
gaps are evident. Further research and comprehensive reporting
may provide a better understanding of ZIKV infection in
pregnancy and attendant maternal/fetal complications. This
knowledge could inform the creation of effective and
evidence-based strategies, guidelines and recommendations aimed
at the management of maternal ZIKV infection. Adherence to
current best practice guidelines for prenatal care among health
providers is encouraged, in the context of maternal ZIKV
infection
Compound Heterozygous ALDH7A1 Mutation Causes the Hemi-Allelic Expression in a Patient with Pyridoxine-Dependent Epilepsy
Tooth Loss and Carotid Intima-Media Thickness in Relation to Functional Atherosclerosis: A Cross-Sectional Study
Structural arterial stiffness can be evaluated with carotid intima-media thickness (CIMT). Functional arterial stiffness can be evaluated with cardio-ankle vascular index (CAVI). A positive association between CIMT and tooth loss has been reported, but no studies have evaluated the association between CIMT and tooth loss in relation to functional arterial stiffness (functional atherosclerosis). A cross-sectional study of 1235 Japanese individuals aged 40–89 years was conducted. Tooth loss was defined as being in the lowest tertile for the number of remaining teeth (≤20 in men and ≤19 in women). Functional atherosclerosis was defined as CAVI ≥ 9.0. Independent of known confounding factors, CIMT was positively associated with tooth loss only in participants without functional atherosclerosis. Adjusted odds ratios for tooth loss and a 1 standard deviation increment in CIMT were 1.27 (1.04–1.55) for participants without functional atherosclerosis and 0.99 (0.77–1.26) for participants with functional atherosclerosis. CIMT and functional atherosclerosis had a significant effect on tooth loss; the fully adjusted p-value for the interaction on tooth loss was 0.019. Independent of known confounding factors, CIMT is positively associated with tooth loss only in participants without functional atherosclerosis. This finding helps clarify the influence of the progression of arterial stiffness on tooth loss because the progression of structural atherosclerosis might have a beneficial influence on the maintenance of the microcirculation
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