Metabolomics approach to studying minimally processed peach (Prunus persica) fruit

Fresh-cut fruit products for both retail and food service applications have increasingly appeared in the market place in recent years. Among different fruit types, peaches can be used and are highly appreciated as fresh-cut product although their commercial success is limited due to their short shelf-life and the quick onset of wounding-related physiological reactions. In this work we analyzed the technological and physiological changes induced by fresh-cut preparation in three different types of peach cultivars: 'Fayette' (melting), 'Wilhelmina' (non-melting) and 'Ghiaccio3' (stony hard). We performed a metabolite targeting profiling to focus on the changes in organic acid levels, important components of fruit taste and organoleptic quality of peaches. Interestingly, 'Ghiaccio3' showed an increase of several organic acids after cutting while 'Fayette' and 'Wilhelmina' showed unchanged amounts or a general reduction. Cutting induces a similar pattern of change in important metabolites (i.e., dehydroascorbate, alanine) in all the three peach types while other metabolites (i.e., citric acid) appeared to be differentially regulated in the considered peach cultivars

Health Care Expenditure and Income: a Global Perspective

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Effect of ethylene on postharvest strawberry fruit tissue biochemistry

The effect of continuous ethylene supplementation (50 µL L-1) on cold-stored strawberry fruit physiology and biochemistry, including phytohormone (abscisic acid) metabolism was investigated. In comparison with control fruit which exhibited high sucrose and malic acid contents during storage, ethylene-treated fruits showed increased respiration, sucrose hydrolysis and concomitant reducing sugars accumulation. Ethylene supplementation did not have any effect on phenolic profile. ABA biosynthesis, in both flesh and achenes, was promoted by ethylene. The results herein suggest that controlling ethylene after harvest could suppress senescence and extend shelf-life

Remote monitoring and telemedicine in heart failure: implementation and benefits

Purpose of review: Remote monitoring (RM) of cardiac implantable electronic devices (CIEDs) is recommended as part of the individualized multidisciplinary follow-up of heart failure (HF) patients. Aim of this article is to critically review recent findings on RM, highlighting potential benefits and barriers to its implementation. Recent findings: Device-based RM is useful in the early detection of CIEDs technical issues and cardiac arrhythmias. Moreover, RM allows the continuous monitoring of several patients' clinical parameters associated with impending HF decompensation, but there is still uncertainty regarding its effectiveness in reducing mortality and hospitalizations. Summary: Implementation of RM strategies, together with a proactive physicians' attitude towards clinical actions in response to RM data reception, will make RM a more valuable tool, potentially leading to better outcomes

Cancer prevention by targeting angiogenesis

Healthy individuals can harbour microscopic tumours and dysplastic foci in different organs in an undetectable and asymptomatic state for many years. These lesions do not progress in the absence of angiogenesis or inflammation. Targeting both processes before clinical manifestation can prevent tumour growth and progression. Angioprevention is a chemoprevention approach that interrupts the formation of new blood vessels when tumour cell foci are in an indolent state. Many efficacious chemopreventive drugs function by preventing angiogenesis in the tumour microenvironment. Blocking the vascularization of incipient tumours should maintain a dormancy state such that neoplasia or cancer exist without disease. The current limitations of antiangiogenic cancer therapy may well be related to the use of antiangiogenic agents too late in the disease course. In this Review, we suggest mechanisms and strategies for using antiangiogenesis agents in a safe, preventive clinical angioprevention setting, proposing different levels of clinical angioprevention according to risk, and indicate potential drugs to be employed at these levels. Finally, angioprevention may go well beyond cancer in the prevention of a range of chronic disorders where angiogenesis is crucial, including different forms of inflammatory or autoimmune diseases, ocular disorders, and neurodegeneration

The role of economic news in predicting suicides

JEL classification: I14; I15.Data availability: The authors do not have permission to share data.Appendix. Brief overview of the WordNet-Affect: A synset is a group of data elements that are considered semantically equivalent for the purposes of information retrieval. WordNet-Affect is an extension of WordNet Domains (see Magnini and Cavaglià, 2000), that includes a set of synsets suitable to represent affective concepts representing moods, situations eliciting emotions, or emotional responses. The authors specifically initially identified a set of words that directly refer to emotional states (e.g. fear, cheerful, sad). Then, they expanded this initial set by implementing an unsupervised algorithm that exploited a mechanism of semantic similarity to automatically acquire from a large corpus of texts (100 millions of words). The final data set includes 1641 terms characterising 28 different emotions. Further information on the approach are available at the web link https://wndomains.fbk.eu/wnaffect.html .In this paper we explore the role of media and language used to comment on economic news in nowcasting and forecasting suicides in England and Wales. This is an interesting question, given the large delay in the release of official statistics on suicides. We use a large data set of over 200,000 news articles published in six major UK newspapers from 2001 to 2015 and carry sentiment analysis of the language used to comment on economic news. We extract daily indicators measuring a set of negative emotions that are often associated with poor mental health and use them to explain and forecast national daily suicide figures. We find that highly negative comments on the economic situation in newspaper articles are predictors of higher suicide numbers, especially when using words conveying stronger emotions of fear and despair. Our results suggest that media language carrying very strong, negative feelings is an early signal of a deterioration in a population’s mental health

Evolution, Composition, Assembly, and Function of the Conoid in Apicomplexa.

The phylum Apicomplexa has been defined by the presence of the apical complex, a structure composed of secretory organelles and specific cytoskeletal elements. A conspicuous feature of the apical complex in many apicomplexans is the conoid, a hollow tapered barrel structure composed of tubulin fibers. In Toxoplasma gondii, the apical complex is a central site of convergence for calcium-related and lipid-mediated signaling pathways that coordinate conoid protrusion, microneme secretion, and actin polymerization, to initiate gliding motility. Through cutting-edge technologies, great progress has recently been made in discovering the structural subcomponents and proteins implicated in the biogenesis and stability of the apical complex and, in turn, these discoveries have shed new light on the function and evolution of this definitive structure

Double-Tuned Birdcage Radio Frequency Coil for 7 T MRI: Optimization, Construction and Workbench Validation

The aim of the present study is the optimization, construction, and workbench validation of a double-tuned 1H- 23Na volume radio frequency (RF) coil suitable for human head imaging at 7 T, based on the birdcage geometry. The birdcage-like design which is considered is the four-ring model, in which two standard birdcage-like structures with the same diameters are nested along the longitudinal axis. Simulations based on Maxwell’s equations are performed to evaluate the RF magnetic field homogeneity and the RF coil efficiency varying the coil geometrical parameters. The RF magnetic field homogeneity is evaluated both on the transverse (z = 0) and longitudinal (y = 0) planes without performing the impedance matching procedure, so that the RF coil symmetry is not perturbed by the matching network. The RF coil efficiency is instead dependent on the effective coil input RF power, and it is evaluated after matching the coil, so that the reflected power is minimized, assuming that the stimulation power is totally delivered to the RF coil. Considering the simulation results and the target application, the useful RF coil geometrical parameters are fixed. The four-ring model, which showed the best performances, has been built and tested on a workbench, using a cylindrical phantom filled with a 0.05 M saline solution as load. This provides the first example of a four-ring realization intended 1H- 23Na for human head imaging at 7 T