Carbohydrates plus protein reduces oxidative stress after single bout of aerobic exercise

The aim of this study was to investigate the effect of CPA in muscle damage and oxidative stress induced by aerobic exercise. Participate in the study ten healthy young (24 ± 4 years), eutrophic (23.2 ± 1 kg/m2),VO2max = 44.9 ± 10 ml/kg/min, four women performed three aerobic exercise sessions lasting 50 minutes randomly supplemented with water (WAT), isolated carbohydrate (CHO) or carbohydrate associated with proteins and antioxidants (CPA) every 10 minutes of exercise. Blood samples were taken before, immediately and 24 hours after each exercise session for analysis markers of muscle damage creatine kinase (CK) and oxidative stress malondialdehyde (MDA). Blood glucose was measured before, during and after the exercise. After testing the data for normality and homogeneity through the Shapiro-Wilk and Levine tests, one-way ANOVA or two-way analyses were made to compare the initial and the answers to the experimental procedure respectively, or their corresponding non-parametric. CHO and CPA resulted in maintaining or increasing glucose, respectively, during exercise, whereas WAT resulted in glycemia reduction. CHO or CPA did not affect CK post exercise concentration. MDA values were very similar immediately after exercise between CHO and CPA, however occurred significant reduction from post exercice to 24 hours after exercise in CPA procedure (4.8 ± 1.8 to 2.5 ± 0.8, p <0,05), while CHO (5.1 ± 0.8 to 4.6 ± 0.9) and WAT (4.9 ± 0.9 to 5.1 ± 0.6) did not promotes the same phenomenon. This study revealed that carbohydrates associated with proteins and antioxidants have ergogenic effect by increasing blood glucose during a single bout of aerobic exercise and accelerate the restoration of oxidative stress

AVALIAÇÃO DE FATORES DE RISCO ASSOCIADOS À DEFICIÊNCIA DE VITAMINA A EM IDOSOS INSTITUCIONALIZADOS DA CIDADE DE JOÃO PESSOA - PB

A deficiência de vitamina A e os distúrbios neurológicos em idososconstituem problemas de Saúde Pública que devem ter mais atençãopor parte das políticas públicas do idoso institucionalizado, devido àsua gravidade e diversidade de causas. Assim, este estudo objetivaavaliar os fatores de risco associados à deficiência de vitamina A emidosos institucionalizados da cidade de João Pessoa-PB. Trata-sede um estudo transversal e analítico, em que foram selecionados105 idosos, ≥60 anos, de cinco Instituições de Longa Permanênciapara Idosos. Avaliaram-se parâmetros sociodemográficos, clínicos,antropométricos, de retinolemia, de consumo de vitamina A, deestresse oxidativo e inflamação. Encontrou-se uma prevalência dedeficiência de vitamina A (0,05). Os indivíduosesquizofrênicos possuem 7,75 (p =0,00; IC 95% = 2,56-26,59) vezesmais chances de serem deficientes de retinol sérico, independentemente de outros fatores de risco. Assim, existe a necessidade deadoção de medidas de saúde pública e um maior controle dessesfatores de risco que podem piorar/afetar a qualidade de vida dessapopulação idosa institucionalizada

PREVALÊNCIA DE HIPOVITAMINOSE D E ASSOCIAÇÕES COM PARÂMETROS METABÓLICOS EM TRABALHADORES

A hipovitaminose D é considerada uma epidemia mundial com implicações que podem afetar a saúde dos trabalhadores. Trata-se de um estudo transversal, realizado com 91 trabalhadores, a fim de avaliar a prevalência da hipovitaminose D e associações com parâmetros metabólicos. Os participantes foram avaliados quanto ao perfil sociodemográfico e ocupacional, exposição solar, antropometria e pressão arterial. Foram realizados os exames: 25-hidroxivitamina D [25(OH)D] e demais parâmetros metabólicos. Verificou-se uma prevalência de 61,54% de deficiência/insuficiência dos níveis séricos de 25(OH)D. Não foram observadas associações entre as características sociodemográficas e ocupacionais e o status de vitamina D, pela Regressão de Poisson. Verificou-se uma prevalência aumentada em portadores de diabetes e hipertrigliceridemia. Indivíduos com maior CAT apresentaram uma redução na prevalência de hipovitaminose D. Em conclusão, verificou-se uma alta prevalência de hipovitaminose D entre os trabalhadores, e uma prevalência aumentada para os indivíduos diabéticos e com hipertrigliceridemia e a CAT como influenciável para redução dessa deficiência/insuficiência. Enfatiza-se a necessidade de um monitoramento dos parâmetros laboratoriais em vigilância à saúde do trabalhador

AVALIAÇÃO DE FATORES DE RISCO ASSOCIADOS À DEFICIÊNCIA DE VITAMINA A EM IDOSOS INSTITUCIONALIZADOS DA CIDADE DE JOÃO PESSOA - PB

A deficiência de vitamina A e os distúrbios neurológicos em idososconstituem problemas de Saúde Pública que devem ter mais atençãopor parte das políticas públicas do idoso institucionalizado, devido àsua gravidade e diversidade de causas. Assim, este estudo objetivaavaliar os fatores de risco associados à deficiência de vitamina A emidosos institucionalizados da cidade de João Pessoa-PB. Trata-sede um estudo transversal e analítico, em que foram selecionados105 idosos, ≥60 anos, de cinco Instituições de Longa Permanênciapara Idosos. Avaliaram-se parâmetros sociodemográficos, clínicos,antropométricos, de retinolemia, de consumo de vitamina A, deestresse oxidativo e inflamação. Encontrou-se uma prevalência dedeficiência de vitamina A (&lt;1,05 micromol/L) em 30,5% da amostra(32 idosos). Em relação ao consumo de alimentos – fonte de vitamina A, 68,6% (72 idosos) da amostra consumiam os de origemanimal numa frequência maior do que 3x/semana, enquanto que osalimentos de origem vegetal eram consumidos por 64,8% (68 idosos)da amostra, nessa mesma frequência. A capacidade antioxidantetotal foi quantificada em 10±17 % e o malondialdeído 3,3±1µmol; aalfa glicoproteína ácida em 38±33 mg/dL (p&gt;0,05). Os indivíduosesquizofrênicos possuem 7,75 (p =0,00; IC 95% = 2,56-26,59) vezesmais chances de serem deficientes de retinol sérico, independentemente de outros fatores de risco. Assim, existe a necessidade deadoção de medidas de saúde pública e um maior controle dessesfatores de risco que podem piorar/afetar a qualidade de vida dessapopulação idosa institucionalizada

Hymenaea rubriflora Ducke stem bark extract has vasorelaxant and contractile inhibition capacity

Abstract We investigated the vasodilatory effects of Hymenaea rubriflora Ducke stem bark extract (HR- HAc). Vascular reactivity of the aortic rings of Wistar rats was tested by in vitro cumulative doses (0.1 - 729 μg/mL). Rats (n=5) were treated with 25 (G25), 50 (G50) and 100 (G100) mg/ kg of HR-HAc or saline (control group - CG) for four weeks. An in vitro assay resulted in dose-dependent relaxation of the aortic rings with functional endothelium, which was inhibited in the presence of L-NAME. Rings of the treated animals increased acetylcholine relaxing potency at all doses, with a greater effect on G50 (pD2 = 7.8±0.1, Emax = 95.6±1.1) and a decreased contractile potency to phenylephrine in G25 (pD2 = 6.9±0.06, Emax = 61.5±6.0%) and G50 (pD2= 6.6±0.06, Emax = 71.0±8.5%) when compared to the CG in the presence and absence of endothelium (pD2= 6.4± 0.1, 6.4±0.1 and 6.9±0.1, respectively). Cumulative doses of nitroprusside resulted in increased relaxing potency in all treated groups and maintained Emax at 100%. It is concluded that HR-HAc has vasorelaxant capacity and inhibitory vascular contraction activity applied either directly to aortic rings or after treatment with in vivo supplementation, which places this extract as a potential nutraceutical or pharmacological agent for treating diseases associated with vascular dysfunction

Supplementation with <i>Spirulina platensis</i> Prevents Damage to Rat Erections in a Model of Erectile Dysfunction Promoted by Hypercaloric Diet-Induced Obesity

Erectile dysfunction (ED) is the inability to achieve and/or maintain a penile erection sufficient for sexual satisfaction. Currently, many patients do not respond to the pharmacotherapy. The effects of a supplementation with Spirulina platensis, were evaluated in a model of ED induced by hypercaloric diet consumption. Wistar rats were divided into groups fed with standard diet (SD) or hypercaloric diet (HD) and supplemented with this alga at doses of 25, 50 or 100 mg/kg. Experimental adiposity parameters and erectile function were analyzed. In SD groups, Spirulina platensis reduced food intake, final body mass and adiposity index, and increased the total antioxidant capacity (TAC) of adipose tissue. However, no change was observed in erectile function. In the HD group, without Spirulina supplementation, a decrease in food intake was observed, in addition to an increase of final body mass, weight gain, adipose reserves, and adiposity index. Additionally, reduction in the number and increase in the latency of penile erection and adipose malondialdehyde levels, as well as a reduction in TCA was noted. Furthermore, cavernous contractility was increased, and the relaxing response was decreased. Interestingly, these deleterious effects were prevented by the algae at doses of 25, 50 and/or 100 mg/kg. Therefore, the supplementation with S. platensis prevents damages associated to a hypercaloric diet consumption and emerges as an adjuvant the prevention of ED

Potential Therapeutic Role of Dietary Supplementation with Spirulina platensis on the Erectile Function of Obese Rats Fed a Hypercaloric Diet

Spirulina platensis, an important source of bioactive compounds, is a multicellular, filamentous cyanobacterium rich in high-quality proteins, vitamins, minerals, and antioxidants. Due to its nutrient composition, the alga is considered a complete food and is recognized for its anti-inflammatory, antioxidant, antiobesity, and reproprotective effects. All of which are important for prevention and treatment of organic and metabolic disorders such as obesity and erectile dysfunction. The aim of this study was to investigate the modulatory role of Spirulina platensis food supplementation and the mechanisms of action involved in reversing the damage caused by a hypercaloric diet on the erectile function of rats. The animals were divided into a standard diet group (SD, n=5); a hypercaloric diet group (HCD, n=5); a hypercaloric diet group supplemented with S. platensis at doses of 25 (HCD+SP25, n=5), 50 (HCD+SP50, n=5), and 100 mg/kg (HCD+SP100, n=5); and a hypercaloric diet group subsequently fed a standard diet (HCD+SD, n=5). In the rats fed a hypercaloric diet, dietary supplementation with S. platensis effectively increased the number of erections while decreasing latency to initiate penile erection. Additionally, S. platensis increases NO bioavailability, reduces inflammation by reducing the release of contractile prostanoids, enhances the relaxation effect promoted by acetylcholine (ACh), restores contractile reactivity damage and cavernous relaxation, reduces reactive oxygen species (ROS), and increases cavernous total antioxidant capacity (TAC). Food supplementation with S. platensis thus restores erectile function in obese rats, reduces production of contractile prostanoids, reduces oxidative stress, and increases NO bioavailability. Food supplementation with S. platensis thus emerges as a promising new therapeutic alternative for the treatment of erectile dysfunction as induced by obesity