Living-donor lobar lung transplantation for rapidly progressive interstitial pneumonia associated with clinically amyopathic dermatomyositis: report of a case.

Diffuse interstitial pneumonia (IP) associated with collagen disease is a rare indication for lung transplantation. The manifestations of collagen disease are variable and dermatomyositis (DM) is often considered a contraindication for lung transplantation because of active myositis and a high incidence of malignancy. Furthermore, clinically amyopathic dermatomyositis (C-ADM) is associated with rapidly progressive IP resulting in a poor prognosis. Bilateral living-donor lobar lung was transplanted in a 52-year-old female with rapidly progressive IP associated with C-ADM, and the postoperative course was uneventful. To our knowledge, this case represents the first living-donor lobar lung transplantation for a patient with rapidly progressive IP associated with C-ADM

ジュウド ツイカンバン ヘルニア オ テイシタ ダックスフンド 5ショウレイ ニタイスル リガク リョウホウシ ノ カイニュウ ト リガク リョウホウ プログラム ニ カンスル コウサツ

The objective of this study was to verify the effect of professional interventions by physical therapists on dachshunds that had intervertebral disc herniation with persistent inability to walk. Subjects were 5 dachshunds diagnosed with intervertebral disc herniation and associated paraplegia; they had failed to regain their ability to walk even 2 months after corrective surgery. We administered professional physical therapy and low-frequency therapy to the subjects for 2 months. At the end of 2 months, 3 dogs were able to stand up and maintain the standing position, while 2 were capable of assisted walking. We presumed that this improvement in the locomotory function of the dogs was considerably influenced by the induction of spinal reflexes and exercise therapy that were based on motion dynamics. Because the therapy was based on the knowledge of physical therapy for humans, the results suggest that physical therapists can contribute to the enhancement of animal medical care and, thereby, the welfare of owners

AN EXAMINATION OF GRAFT ALTERATION AND RECIPIENT RESPONSE TO PROCESSED MARE CORTICAL BONE XENOGRAFTING

The examination was conducted in order to investigate the effectiveness of horse bone xenografting and to compare the differences in various processed bone graft. The grafts of mare cortical bones processed by boiling, freezing, and deproteinization were implanted into the humeral bone marrow of adult mongrel dogs and fresh grafts were used as controls. The results were summarized as follows. 1) By roentgenographic examination, the bone graft density was increased quickly in order of deproteinized, frozen, boiled, and fresh graft. 2) By gross appearance, the ossal fusion between the graft and the recipient was completed in all deproteinized and frozen grafts and in a few boiled and fresh graft. 3) The bone replacement in graft was not found up to 16 weeks after implantation in all the processed and fresh grafts. 4) The major bone mineral contents at the end of 16 weeks after implantation were nearly in agreement with the absorption rate in each graft. 5)There were no changes on blood cells and serum electrophoretic fractions of recipients implanted with non-processed fresh graft

CHANGES OF SERUM CYTOKINE ACTIVITIES AND OTHER PARAMETERS IN DOGS WITH EXPERIMENTALLY INDUCED ENDOTOXIC SHOCK

To study the relationship of changes of cytokines in endotoxic shock, serum tumor necrosis factor (TNF), interleukin (IL)-1 and IL-6 like activities, together with physiologic and hemodynamic responses, were examined in dogs before and after intravenous administration of lipopolysaccharide (LPS) purified from Escherichia coli in a dose of 500 μg/kg of body weight. The blood endotoxin concentration increased significantly at 30 min after LPS administration, and maintained high levels for 24 hr. Red blood cell counts, hemoglobin concentration and hematocrit values increased at 30 min, and these high values persisted for 24 hr. The platelet count decreased significantly at 30 min, then showed a tendency to recover, but decreased again at 24 hr. Cardiac output, cardiac index and mean arterial pressure showed transient, significant decreases at 15 min, and then returned to the baseline levels by 24 hr. TNF-like activities increased at 30 min, while IL-1-like activities did so between 30 and 60 min. The former reached the maximal levels at 2 hr and the latter at 1.5 hr. Both activities were then hardly detectable from 6 to 24 hr. IL-6-like activities elevated at 1 hr with the peak at 1.5 hr, and remained high until 24 hr

ULTRASONOGRAPHY AND ANGIOGRAPHIC EXAMINATION OF NORMAL CANINE LIVER VESSELS

The aim of this study is to provide a description of the ultrasonographic and angiographic anatomy of the hepatic and portal veins in normal dogs. Knowledge of this anatomy is essential for the proper diagnosis and correction of hepatic vessel anomalies like portal systemic shunts. Cranial mesenteric portography was done in 10 adult mongrel dogs to visualize the portal vein and its branches while the hepatic veins were visualized using the transvenous retrograde angiography method. Longitudinal and transverse ultrasound scans of the liver were done in the same dogs in left and right lateral positions in order to determine the best positions for imaging the different liver vessels. The distribution pattern of the hepatic and portal veins could be demonstrated by both ultrasonography and contrast angiography. Hepatic arteries are not usually visualized ultrasonographically. Ultrasound provided dynamic information that could not be obtained by contrast radiography. Super imposition of all vessels in the angiographic studies made the description of the branches of the liver vessels difficult. The results of the present study suggest that both methods may provide important complementary information in the diagnosis and planning of surgical procedures for the correction of vessel anomalies in the canine liver

Ultrasonographic evaluation of portal vein hemodynamics in experimentally bile duct ligated dogs

The purpose of this study was to evaluate the relationship between the results of laboratory examinations and ultrasonographic findings, especially portal vein hemodynamics in experimentally bile duct ligated dogs. Biliary obstruction was accomplished by surgically occluding the common bile duct in five dogs. All the dogs became visibly jaundiced within 24 hours after surgery. The total protein and albumin/globulin ratio showed a gradual decrease throughout the examination period, while blood urea nitrogen reached its peak in the 6th week and decreased to pre ligation values by the 10th week. Similar trends were noted in the alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, and direct and total bilirubin. Total cholesterol and fasting serum bile acid levels rapidly increased after surgery to peak values between the 2nd and 4th week, and then gradually decreased, but still remained high throughout the experiment period. The portal flow volume and velocity significantly (p<0.05) decreased while only a slight increase was noted in the congestion index after bile duct ligation. The cross sectional area of the portal vein changed insignificantly. Bile duct and gallbladder distention was evident within the 1st week after ligation but there was little change in the echogenicity of the liver parenchyma. The results of this study suggest that the determination of Doppler ultrasound parameters of hepatic hemodynamics, especially the portal vein flow indices, may contribute to a better noninvasive assessment of the canine patient with biliary obstructive disease