Diabetic Mastopathy as a Radiographically Occult Palpable Breast Mass

Diabetic mastopathy is an uncommon, benign disease of the breast that can occur in women with diabetes and clinically mimic breast cancer. We describe a patient with long-standing type 1 diabetes who presented with a palpable breast mass with negative imaging findings on mammography, ultrasonography, and breast MRI. Surgical biopsy and histopathology confirmed diabetic mastopathy. We use this case to highlight the recognition, radiographic features, pathology, and management of this benign breast condition and emphasize that, in diabetic patients, the differential diagnosis of a new breast mass should include diabetic mastopathy

Searching for galaxy-scale strong-lenses in galaxy clusters with deep networks -- I: methodology and network performance

Galaxy-scale strong lenses in galaxy clusters provide a unique tool to investigate their inner mass distribution and the sub-halo density profiles in the low-mass regime, which can be compared with the predictions from cosmological simulations. We search for galaxy-galaxy strong-lensing systems in HST multi-band imaging of galaxy cluster cores from the CLASH and HFF programs by exploring the classification capabilities of deep learning techniques. Convolutional neural networks are trained utilising highly-realistic simulations of galaxy-scale strong lenses injected into the HST cluster fields around cluster members. To this aim, we take advantage of extensive spectroscopic information on member galaxies in 16 clusters and the accurate knowledge of the deflection fields in half of these from high-precision strong lensing models. Using observationally-based distributions, we sample magnitudes, redshifts and sizes of the background galaxy population. By placing these sources within the secondary caustics associated with cluster galaxies, we build a sample of ~3000 galaxy-galaxy strong lenses which preserve the full complexity of real multi-colour data and produce a wide diversity of strong lensing configurations. We study two deep learning networks processing a large sample of image cutouts in three HST/ACS bands, and we quantify their classification performance using several standard metrics. We find that both networks achieve a very good trade-off between purity and completeness (85%-95%), as well as good stability with fluctuations within 2%-4%. We characterise the limited number of false negatives and false positives in terms of the physical properties of the background sources and cluster members. We also demonstrate the neural networks' high degree of generalisation by applying our method to HST observations of 12 clusters with previously known galaxy-scale lensing systems.Comment: 17 pages, 13 figures, to be published on A&

The Kormendy relation of early-type galaxies as a function of wavelength in Abell S1063, MACS J0416.1-2403 and MACS J1149.5+2223

The wavelength dependence of the Kormendy relation (KR) is well characterised at low-redshift, but poorly studied at intermediate redshifts. The KR provides information on the evolution of the population of early-type galaxies (ETGs), therefore, by studying it, we may shed light on the assembly processes of these objects and their size evolution. Since studies at different redshifts are generally conducted in different rest-frame wavebands, investigating whether there is a wavelength dependence of the KR is fundamental to interpret the conclusions we might draw from it. We analyse the KRs of the three Hubble Frontier Fields clusters, Abell S1063 (z = 0.348), MACS J0416.1-2403 (z = 0.396), and MACS J1149.5+2223 (z = 0.542), as a function of wavelength. This is the first time the KR of ETGs has been explored consistently in such a large range of wavelength at intermediate redshifts. We exploit very deep HST photometry, ranging from the observed B-band to the H-band, and VLT/MUSE integral field spectroscopy. We improve the structural parameters estimation we performed in a previous work (Tortorelli et al. 2018) by means of a newly developed Python package called morphofit (Tortorelli&Mercurio 2023). With its use on cluster ETGs, we find that the KR slopes smoothly increase with wavelength from the optical to the near-infrared bands in all three clusters, with the intercepts getting fainter at lower redshifts due to the passivisation of the ETGs population. The slope trend is consistent with previous findings at lower redshifts. The slope increase with wavelength implies that smaller size ETGs are more centrally concentrated than larger size ETGs in the near-infrared with respect to the optical regime. Since different bands probe different stellar populations in galaxies, the slope increase also implies that smaller ETGs have stronger internal gradients with respect to larger ETGs.Comment: Submitted to Astronomy and Astrophysics in the form of letter to the Editor, 5 pages, 1 figure, 1 tabl

Cost-Effective Surface Modification for Metallic Bipolar Plates

Presented at the 2006 DOE Hydrogen, Fuel Cells & Infrastructure Technologies Program Annual Merit Review in Washington, D.C., May 16-19, 2006

Ultrahigh temperature intermetallic alloys

A new family of Cr-Cr{sub 2}Ta intermetallic alloys based on Cr-(6--10)Ta (at.%) is under development for structural use in oxidizing environments in the 1,000-1,300 C (1,832--2,372 F) temperature range. Development objectives relate to high temperature strength and oxidation resistance and room temperature fracture toughness. The 1,200 C (2,192 F) strength goals have been met: yield and fracture strengths of 275 MPa (40 ksi) and 345 MPa (50 ksi), respectively, were achieved. Progress in attaining reasonable fracture toughness of Cr-Cr{sub 2}Ta alloys has been made; current alloys exhibit room-temperature values of about 10--12 MPa{radical}m (1.1 MPa{radical}m = 1 ksi{radical}in.). Oxidation rates of these alloys at 950 C (1,742 F) in air are in the range of those reported for chromia-forming alloys. At 1,100 C (2,012 F) in air, chromia volatility was significant but, nevertheless, no scale spallation and positive weight gains of 1--5 mg/cm{sup 2} have been observed during 120-h, 6-cycle oxidation screening tests. These mechanical and oxidative properties represent substantial improvement over Cr-Cr{sub 2}Nb and Cr-Cr{sub 2}Zr alloys previously developed

Moonlighting Newborn Screening Markers: The Incidental Discovery of a Second-Tier Test for Pompe Disease

Purpose: To describe a novel biochemical marker in dried blood spots suitable to improve the specificity of newborn screening for Pompe disease. Methods: The new marker is a ratio calculated between the creatine/creatinine (Cre/Crn) ratio as the numerator and the activity of acid α-glucosidase (GAA) as the denominator. Using Collaborative Laboratory Integrated Reports (CLIR), the new marker was incorporated in a dual scatter plot that can achieve almost complete segregation between Pompe disease and false-positive cases. Results: The (Cre/Crn)/GAA ratio was measured in residual dried blood spots of five Pompe cases and was found to be elevated (range 4.41–13.26; 99%ile of neonatal controls: 1.10). Verification was by analysis of 39 blinded specimens that included 10 controls, 24 samples with a definitive classification (16 Pompe, 8 false positives), and 5 with genotypes of uncertain significance. The CLIR tool showed 100% concordance of classification for the 24 known cases. Of the remaining five cases, three p.V222M homozygotes, a benign variant, were classified by CLIR as false positives; two with genotypes of unknown significance, one likely informative, were categorized as Pompe disease. Conclusion: The CLIR tool inclusive of the new ratio could have prevented at least 12 of 13 (92%) false-positive outcomes

Precision Newborn Screening for Lysosomal Disorders

Purpose: The implementation of newborn screening for lysosomal disorders has uncovered overall poor specificity, psychosocial harm experienced by caregivers, and costly follow-up testing of false-positive cases. We report an informatics solution proven to minimize these issues. Methods: The Kentucky Department for Public Health outsourced testing for mucopolysaccharidosis type I (MPS I) and Pompe disease, conditions recently added to the recommended uniform screening panel, plus Krabbe disease, which was added by legislative mandate. A total of 55,161 specimens were collected from infants born over 1 year starting from February 2016. Testing by tandem mass spectrometry was integrated with multivariate pattern recognition software (Collaborative Laboratory Integrated Reports), which is freely available to newborn screening programs for selection of cases for which a biochemical second-tier test is needed. Results: Of five presumptive positive cases, one was affected with infantile Krabbe disease, two with Pompe disease, and one with MPS I. The remaining case was a heterozygote for the latter condition. The false-positive rate was 0.0018% and the positive predictive value was 80%. Conclusion: Postanalytical interpretive tools can drastically reduce false-positive outcomes, with preliminary evidence of no greater risk of false-negative events, still to be verified by long-term surveillance

The PAU Survey: a new constraint on galaxy formation models using the observed colour redshift relation

We use the GALFORM semi-analytical galaxy formation model implemented in the Planck Millennium N-body simulation to build a mock galaxy catalogue on an observer’s past lightcone. The mass resolution of this N-body simulation is almost an order of magnitude better than in previous simulations used for this purpose, allowing us to probe fainter galaxies and hence build a more complete mock catalogue at low redshifts. The high time cadence of the simulation outputs allows us to make improved calculations of galaxy properties and positions in the mock. We test the predictions of the mock against the Physics of the Accelerating Universe Survey, a narrow-band imaging survey with highly accurate and precise photometric redshifts, which probes the galaxy population over a lookback time of 8 billion years. We compare the model against the observed number counts, redshift distribution, and evolution of the observed colours and find good agreement; these statistics avoid the need for model-dependent processing of the observations. The model produces red and blue populations that have similar median colours to the observations. However, the bimodality of galaxy colours in the model is stronger than in the observations. This bimodality is reduced on including a simple model for errors in the GALFORM photometry. We examine how the model predictions for the observed galaxy colours change when perturbing key model parameters. This exercise shows that the median colours and relative abundance of red and blue galaxies provide constraints on the strength of the feedback driven by supernovae used in the model

CLASH-VLT: Abell S1063: Cluster assembly history and spectroscopic catalogue

Context. The processes responsible for galaxy evolution in different environments as a function of galaxy mass remain heavily debated. Rich galaxy clusters are ideal laboratories in which to distinguish the role of environmental versus mass quenching because they consist of a full range of galaxies and environments. Aims. Using the CLASH-VLT survey, we assembled an unprecedentedly large sample of 1234 spectroscopically confirmed members in Abell S1063. We found a dynamically complex structure at «zcl»= 0.3457 with a velocity dispersion σv = 1380-32+26 km s-1. We investigated cluster environmental and dynamical effects by analysing the projected phase-space diagram and the orbits as a function of galaxy spectral properties. Methods. We classified cluster galaxies according to the presence and strength of the [OII] emission line, the strength of the Hδ absorption line, and colours. We investigated the relation between the spectral classes of galaxies and their position in the projected phase-space diagram. We separately analysed red and blue galaxy orbits. By correlating the observed positions and velocities with the projected phase-space constructed from simulations, we constrained the accretion redshift of galaxies with different spectral types. Results. Passive galaxies are mainly located in the virialised region, while emission-line galaxies lie beyond r200 and are accreted into the cluster at a later time. Emission-line and post-starburst galaxies show an asymmetric distribution in projected phase-space within r200; emission-line galaxies are prominent at Δv/σ ≲ -1.5 and post-starburst galaxies at Δv/σ ≲ 1.5, suggesting that backsplash galaxies lie at high positive velocities. We find that low-mass passive galaxies are accreted into the cluster before high-mass galaxies. This suggests that we observe as passives only the low-mass galaxies that are accreted early into the cluster as blue galaxies. They had the time to quench their star formation. We also find that red galaxies move on more radial orbits than blue galaxies. This can be explained if infalling galaxies can remain blue by moving on tangential orbits