Microstrip resonator for microwaves with controllable polarization

In this work the authors implemented a resonator based upon microstrip cavities that permits the generation of microwaves with arbitrary polarization. Design, simulation, and implementation of the resonators were performed using standard printed circuit boards. The electric field distribution was mapped using a scanning probe cavity perturbation technique. Electron spin resonance using a standard marker was carried out in order to verify the polarization control from linear to circular.Comment: 3 pages, 3 figures, submitted to Appl. Phys. Let

Processamento de patê de cachapinta (Pseudoplatystoma sp.).

O objetivo deste trabalho foi determinar um processo para fabricação de patê com carne de cachapinta (Pseudoplatystoma sp.) e verificar a qualidade deste produto através do teste de esterilidade comercial e de aceitação sensorial.bitstream/item/108922/1/2013-CTE-0194.pd

High-Precision Tuning of State for Memristive Devices by Adaptable Variation-Tolerant Algorithm

Using memristive properties common for the titanium dioxide thin film devices, we designed a simple write algorithm to tune device conductance at a specific bias point to 1% relative accuracy (which is roughly equivalent to 7-bit precision) within its dynamic range even in the presence of large variations in switching behavior. The high precision state is nonvolatile and the results are likely to be sustained for nanoscale memristive devices because of the inherent filamentary nature of the resistive switching. The proposed functionality of memristive devices is especially attractive for analog computing with low precision data. As one representative example we demonstrate hybrid circuitry consisting of CMOS summing amplifier and two memristive devices to perform analog multiply and accumulate computation, which is a typical bottleneck operation in information processing.Comment: 20 pages, 6 figure

Hereditary breast and ovarian cancer: assessment of \ud point mutations and copy number variations in \ud Brazilian patients

Background \ud Germ line mutations in BRCA1 and BRCA2 (BRCA1/2) and other susceptibility genes have \ud been identified as genetic causes of hereditary breast and ovarian cancer (HBOC). To identify \ud the disease-causing mutations in a cohort of 120 Brazilian women fulfilling criteria for \ud HBOC, we carried out a comprehensive screening of BRCA1/2, TP53 R337H, CHEK2 \ud 1100delC, followed by an analysis of copy number variations in 14 additional breast cancer \ud susceptibility genes (PTEN, ATM, NBN, RAD50, RAD51, BRIP1, PALB2, MLH1, MSH2, \ud MSH6, TP53, CDKN2A, CDH1 and CTNNB1). \ud Methods \ud Capillary sequencing and multiplex ligation-dependent probe amplification (MLPA) were \ud used for detecting point mutations and copy number variations (CNVs), respectively, for the \ud BRCA1 and BRCA2 genes; capillary sequencing was used for point mutation for both variants \ud TP53 R337H and CHEK2 1100delC, and finally array comparative genomic hybridization \ud (array-CGH) was used for identifying CNVs in the 14 additional genes. \ud Results \ud The positive detection rate in our series was 26%. BRCA1 pathogenic mutations were found \ud in 20 cases, including two cases with CNVs, whereas BRCA2 mutations were found in 7 \ud cases. We also found three patients with the TP53 R337H mutation and one patient with the \ud CHEK2 1100delC mutation. Seven (25%) pathogenic mutations in BRCA1/2 were firstly \ud described, including a splice-site BRCA1 mutation for which pathogenicity was confirmed by \ud the presence of an aberrant transcript showing the loss of the last 62 bp of exon 7. \ud Microdeletions of exon 4 in ATM and exon 2 in PTEN were identified in BRCA2-mutated and \ud BRCA1/2-negative patients, respectively. \ud Conclusions \ud In summary, our results showed a high frequency of BRCA1/2 mutations and a higher \ud prevalence of BRCA1 (64.5%) gene. Moreover, the detection of the TP53 R337H variant in \ud our series and the fact that this variant has a founder effect in our population prompted us to \ud suggest that all female breast cancer patients with clinical criteria for HBOC and negative for \ud BRCA1/2 genes should be tested for the TP53 R337H variant. Furthermore, the presence of \ud genomic structural rearrangement resulting in CNVs in other genes that predispose breast \ud cancer in conjunction with BRCA2 point mutations demonstrated a highly complex genetic \ud etiology in Brazilian breast cancer families.Fundação de Amparo à Pesquisa do Estado de São Paulo (2008/57887- 9).Conselho Nacional de Desenvolvimento Científico e Tecnológico (408833/2006-8

Genomics and epidemiology for gastric adenocarcinomas (GE4GAC): a Brazilian initiative to study gastric cancer

Abstract Gastric cancer (GC) is the fifth most common type of cancer worldwide with high incidences in Asia, Central, and South American countries. This patchy distribution means that GC studies are neglected by large research centers from developed countries. The need for further understanding of this complex disease, including the local importance of epidemiological factors and the rich ancestral admixture found in Brazil, stimulated the implementation of the GE4GAC project. GE4GAC aims to embrace epidemiological, clinical, molecular and microbiological data from Brazilian controls and patients with malignant and pre-malignant gastric disease. In this letter, we summarize the main goals of the project, including subject and sample accrual and current findings

Psoríase e o impacto na sexualidade

Psoriasis is a skin disease, not contagious, chronic, serious and considered limiting, resulting prejudice, stigma and social exclusion providing loss in quality of life.Mostly affects self-image of affected people, as well as self-esteem and self-concept.These disease characteristics bring great losses in occupational areas, damaging interpersonal relationships of individuals, which may cause impact on various occupational areas, including sexuality, which translates not only as sex itself, but also as identity, social roles, pleasure, reproduction and other. The aim of this study was to investigate the self-image of individuals with psoriasis and their influence on sexuality. This is a qualitative study of a case study with seven patients in the Reference Center, Support and Treatment Paraíba State Psoriasis installed in the clinic of the University Hospital LauroWanderley – Universidade Federal da Paraíba. Data were collected through semi-structured interview, categorized and treated according to the Content Analysis. The results show that psoriasis affects the sexuality of individuals, more significantly in women's fashion, as attribute different meanings to the body, for reasons of aesthetics and beauty.Men also feel affected, but in view of the achievement, caring companionship, and seek to clarify their partners or future partners and their relationships, about the disease. We note here the influence of culture to gender conditions.A Psoríase é uma doença dermatológica, não contagiosa, crônica, considerada grave e limitante, acarretando preconceito, estigma e exclusão social proporcionando prejuízos na qualidade de vida. Na sua grande maioria, afeta a autoimagem das pessoas acometidas, assim como a autoestima e autoconceito. Estas características da doença trazem grandes prejuízos nas áreas ocupacionais, prejudicando as relações interpessoais dos indivíduos, podendo ocasionar impacto em várias áreas ocupacionais, incluindo a sexualidade, que se traduz não só como o sexo em si, mas também como identidade, papéis sociais, prazer, reprodução entre outros. O objetivo deste estudo foi investigar sobre a autoimagem dos indivíduos com psoríase e sua influência na sexualidade. Trata-se de um estudo qualitativo do tipo estudo de caso, com sete pacientes do Centro de Referência, Apoio e Tratamento em Psoríase do Estado da Paraíba instalado no ambulatório do Hospital Universitário Lauro Wanderley – Universidade Federal da Paraíba. Os dados foram coletados por meio de entrevista semiestruturada, categorizados e tratados de acordo com a Análise de Conteúdo. Os resultados encontrados mostram que a psoríase afeta a sexualidade dos indivíduos, de forma mais significativa nas mulheres, pois atribuem significados diferentes ao corpo, por razões de estética e beleza. Os homens também se sentem afetados, mas na perspectiva da conquista, se importando com o companheirismo, e procuram esclarecer para suas companheiras ou futuras companheiras e em seus relacionamentos, sobre a doença. Observamos aqui a influência da cultura às condições de gêner