330 research outputs found
The Impact of Liraglutide on Diabetes-Related Foot Ulceration and Associated Complications in Patients With Type 2 Diabetes at High Risk for Cardiovascular Events: Results From the LEADER Trial
Tetrazine-Triggered Release of Carboxylic-Acid-Containing Molecules for Activation of an Anti-inflammatory Drug.
In addition to its use for the study of biomolecules in living systems, bioorthogonal chemistry has emerged as a promising strategy to enable protein or drug activation in a spatially and temporally controlled manner. This study demonstrates the application of a bioorthogonal inverse electron-demand Diels-Alder (iEDDA) reaction to cleave trans-cyclooctene (TCO) and vinyl protecting groups from carboxylic acid-containing molecules. The tetrazine-mediated decaging reaction proceeded under biocompatible conditions with fast reaction kinetics (<2â
min). The anti-inflammatory activity of ketoprofen was successfully reinstated after decaging of the nontoxic TCOprodrug in live macrophages. Overall, this work expands the scope of functional groups and the application of decaging reactions to a new class of drugs
The potential of bioorthogonal chemistry for correlative light and electron microscopy: a call to arms
Bio-organic Synthesi
Macroporous polymer supported azide and nanocopper (I): efficient and reusable reagent and catalyst for multicomponent click synthesis of 1,4-disubstituted-1H-1,2,3-triazoles from benzyl halides
A mobile hospice nurse teaching teamâs experience: training care workers in spiritual and existential care for the dying - a qualitative study
The challenge of consolation: nursesâ experiences with spiritual and existential care for the dying-a phenomenological hermeneutical study
Synthesis of carboxylated derivatives of poly(isobutylene-co-isoprene) by azideâalkyne âclickâ chemistry
The final publication is available at Springer via https://dx.doi.org/10.1038/s41428-018-0130-yThe synthesis of carboxylated derivatives of poly(isobutylene-co-isoprene) (isobutyleneâisoprene rubber, IIR) with substitution levels ranging from 1 to 4 mol% and different spacer lengths was accomplished through azideâalkyne Huisgen cycloaddition. Azido-functionalized IIR was first prepared by reacting brominated IIR with sodium azide to full conversion in a 90:10 tetrahydrofuran/N,N-dimethylacetamide mixture. The click reaction of azido-functionalized IIR with acetylenic acids, which was carried out using the copper(I) bromide/N,N,Nâ˛,Nâł,Nâł-pentamethyldiethylenetriamine catalyst system in tetrahydrofuran, yielded carboxylated IIRs. The products were characterized by 1H NMR and FT-IR spectroscopy, and their molecular weight was determined by size exclusion chromatography analysis. The conversion to carboxylated groups reached up to 100% as determined by NMR spectroscopy but was highly dependent on the type of solvent and the amounts of catalysts and reactants used in the procedures.ARLANXEO Canada Inc.Natural Sciences and Engineering Research Council (NSERC) of Canad
Use of ring-expanded diamino- and diamidocarbene ligands in copper catalyzed azide-alkyne "click" reactions
The
two-coordinate ring-expanded N-heterocyclic carbene copperÂ(I)
complexes [CuÂ(RE-NHC)<sub>2</sub>]<sup>+</sup> (RE-NHC = 6-Mes, 7-<i>o</i>-Tol, 7-Mes) have been prepared and shown to be effective
catalysts under neat conditions for the 1,3-dipolar cycloaddition
of alkynes and azides. In contrast, the cationic diamidocarbene analogue
[CuÂ(6-MesDAC)<sub>2</sub>]<sup>+</sup> and the neutral species [(6-MesDAC)ÂCuCl]<sub>2</sub> and [(6-MesDAC)<sub>2</sub>(CuCl)<sub>3</sub>] show good
activity when the catalysis is performed on water
Coordinatively Unsaturated Ruthenium Complexes As Efficient AlkyneâAzide Cycloaddition Catalysts
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