Nurses' perceptions of aids and obstacles to the provision of optimal end of life care in ICU

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Portfólio de alianças e desempenho inovador da indústria brasileira

The main objective of this study is to analyze the relationship between Alliance Portfolio Diversity (APD) and the firm's innovative performance, especially when R&D capacity (RDCAP) and Specialized Complementary Assets (SCA) moderate this relationship at different points in the firm’s value chain; the study also identifies the nature of the relationship between such moderators. It applies econometric methods to a database comprised of 13,020 companies from Brazilian industry. The results reveal an inverted U-shaped curvilinear relationship between APD and innovative performance, as well as the effective positive moderation of this relationship by the RDCAP and the SCA. This research contributes to the literature on firm knowledge, especially theories of open innovation and absorptive capacity (AC). The former is progressing to emerging economic contexts and the second, contributing a new way of understanding AC by investigating its spatial dimensions, in addition to the skills and competencies dimensions.O principal objetivo deste artigo é analisar o relacionamento entre a Diversidade do Portfólio de Alianças (DPA) e o desempenho inovador da firma, especialmente quando esse relacionamento é moderado pela capacidade de P&D (CAPPD) e pelos Ativos Complementares Especializados (ACE) em pontos distintos de sua cadeia de valor, bem como identificar a natureza da relação existente entre tais moderadores. Métodos econométricos foram aplicados a uma base de dados composta por 13.020 empresas da indústria brasileira. Os resultados mostraram relação curvilinear em forma de U-invertido entre a DPA e o desempenho inovador, bem como a efetiva moderação positiva desse relacionamento, por parte da CAPPD e dos ACE. Esta pesquisa contribui para a literatura que aborda o conhecimento da firma, especialmente para as teorias da inovação aberta e da capacidade de absorção (CA), a primeira avançando em direção aos contextos econômicos emergentes e a segunda adicionando uma nova forma de compreender a CA, que pode ser investigada também a partir de suas dimensões espaciais, além das dimensões de habilidades e competências

A five years longitudinal magnetic resonance imaging study of severe traumatic brain injury patients. Correlation with functional outcome

International audienceIntroductionTraumatic brain injury (TBI) doesn't seem to be a single insult with amonophasic resolution. Recently, degenerative mechanisms havebeen suggested to occur in the chronic phase and could constituted"tertiary" lesions [1]. These degenerative phenomena can potentiallyhave a worsening impact on the long-term functional prognosis.ObjectivesThe objective of this prospective study was to longitudinally evaluate(1) white and grey matter structures volumes measured from Tlthree-dimensional (30) and (2) white matter integrity assessed fromdiffusion tensor imaging (DTI) in severe TBI.Method20 severe TBI (37 ± 16 yrs) and 12 healthy volunteers (HV; 42 ± 6 yrs)underwent multimodal magnetic resonance imaging in the subacutephase (within 21 ± 8 days after injury). A longitudinal follow-upwas obtained for all of them at the chronic phase of injury (median64 ± 16 months after injury) together with neuropsychological assessments.Longitudinal imaging changes were assessed using corticalvolumetric reconstruction and segmentation of white and deep greymatter structures with Freesurfer [2]; cortical sulci were automaticallyreconstructed and identified with Brainvisa software, and a voxelbasedDTI analysis was performed with Comasoft. The Extended GOS(GOSE) was used to classify at 5 years the TBI subjects into " good"(GOSE 6-7; n = 11) and "intermediate" (GOSE 3-5; n = 9) recovery.Cortical morphometry and fractional anisotropy (FA) derived fromDTI were used with linear mixed effects models to link changes to behaviour status.Results At baseline, there were no volumetric differences between the 3 groups (GOSE 3-5; GOSE 6-7; HV). At 5 years, patients with TBI demonstrated a significant volumetric reduction of the whole white matter (-10±4 %; PConclusions: We observed a strong correlation between neuropsychological scores and morphometric changes over time suggesting (1) occurrence of tertiary lesions and (2) that lesions location influence functional outcome. These data provide further insight into early and late pathophysiology of cognitive dysfunctions after TBI.[no other pdf

Toxicity of lignans to symbiotic fungus of leaf-cutting ants

Lignans from Virola sebifera Aubl., Virola sp., and Otoba parvifolia (Mkfg.) A. Gentry (Myristicaceae) inhibited the in vitro growth of the fungus cultivated by leaf-cutting ants of the species Atta sexdens rubropilosa Forel (Hymenoptera: Formicidae). A comparison of activity among the lignans was obtained

Activity of Extracts and Fatty Acids of Canavalia ensiformis (Leguminosae) Against the Symbiotic Fungus of the Leaf-Cutting Ants Atta sexdens

The inhibitory effect of leaves extracts of Carnavalia ensiformis on the development of the symbiotic fungus of the leaf-cutting ants Atta sexdens (Forel) was evaluated. The hexane extract showed highest activity at concentration of 1000 μg/mL. Chromatographic separations of this extract have led to the isolation of a mixture of fatty acids which showed the same activity of the crude extract