The earliest sources on Martin Seidel: author of "Origo et fundamenta religionis christianae"

El tratado clandestino Origo et fundamenta religionis christianae ataca los fundamentos del cristianismo y propone una religión natural. Pese a que todas las copias manuscritas que lo conservan datan del siglo XVIII, se encuentran suficientes indicios que señalan al silesio Martin Seidel como su autor y documentan la existencia del texto a finales del siglo XVI o principios del XVII. Las primeras fuentes sobre Seidel lo vinculan con los antitrinitarios de Heidelberg (1570), los unitarios polacos (1580) y los “cripto-socinianos” de Altdorf (1610). En este artículo valoro dichas fuentes y corrijo a la luz de las mismas algunas afirmaciones de la crítica reciente sobre Seidel y su Origo.The clandestine manuscript "Origo et fundamenta religionis christianae" attacks the foundations of Christianity and proposes a natural religion. Although all preserved copies date back to the 18th century, there is enough evidence pointing at the authorship of Silesian Martin Seidel, and documenting the existence of the text in the late 16th or early 17th century. The earliest sources on Seidel associate him with the Heidelberg Anti-Trinitarians (1570), the Polish Unitarians (1580) and the Socinian community at Altdorf (1610). In this paper I examine these sources and correct in light of them some assertions made by recent scholarship on Seidel and his "Origo"

Challenge B: Human sciences in transition scenarios

Coordinators: Josep Martí Pérez (IMF, CSIC), Idoia Murga Castro (IH, CSIC).This challenge is formulated in terms of “humanities in transition,” that is, their approach and articulation in the face of the changes they must undergo to achieve the social weight that, due to their intrinsic relevance, should correspond to them. Faced with these situations that would demand a reinforcement in research and dissemination in diverse aspects of the humanities, from multiple perspectives, paradoxically an adverse panorama is drawn for the development and dissemination of humanistic knowledge, which concerns different factors. Some are related to the consideration of the area of knowledge itself, its organization within the scientific system, the questioning of its own limits, and the interaction with another knowledge. Considering current transition scenarios does not mean having to abandon old objectives, but it adds to the work conducted new objects of study closely related to current reality, such as: the informational revolution; the relations with the ecosystem and the environmental crisis; globalization; the intensification of human mobility and migration flows; the growing economic and social inequality; the frictions derived from the articulation of collective identities; the decolonization of discourses; demographic dynamics; integration of technological advances; and viability and support for alternative models of society.Peer reviewe

Immunotherapy with CAR-T cells in paediatric haematology-oncology

Despite being a rare disease, cancer is the first cause of mortality due to disease during the paediatric age in the developed countries. The current, great increase in new treatments, such as immunotherapy, constitutes a new clinical and regulatory paradigm. Cellular immunotherapy is one of these types of immunotherapy. In particular, the advanced therapy drugs with chimeric antigen receptors in the T-lymphocytes (CAR-T), and particularly the CAR-T19 cells, has opened up a new scenario in the approach to haematology tumours like acute lymphoblastic leukaemia and the B-Cell lymphomas. The approval of tisagenlecleucel and axicabtagene ciloleucel by the regulatory authorities has led to the setting up of the National Plan for Advanced Therapies-CAR-T drugs in Spain. There is evidence of, not only the advantage of identifying the centres most suitable for their administration, but also the need for these to undergo a profound change in order that their healthcare activity is extended, in some cases, to the ability for the in-house manufacture of these types of therapies. The hospitals specialised in paediatric haematology-oncology thus have the challenge of progressing towards a healthcare model that integrates cellular immunotherapy, having the appropriate capacity to manage all aspects relative to their use, manufacture, and administration of these new treatments.A pesar de ser una enfermedad rara, el cáncer es la primera causa de mortalidad por enfermedad durante la edad pediátrica en los países desarrollados. En este momento, la irrupción de nuevos tratamientos como la inmunoterapia constituye un nuevo paradigma clínico y regulatorio. Uno de estos tipos de inmunoterapia es la inmunoterapia celular. En particular, los medicamentos de terapia avanzada con receptores antigénicos quiméricos en los linfocitos T (CAR-T), y en concreto las células CAR-T19, han supuesto un nuevo escenario en el abordaje de los tumores hematológicos, como la leucemia aguda linfoblástica y los linfomas de células tipo B. La aprobación por las autoridades regulatorias de tisagenlecleucel y axicabtagene ciloleucel,ha impulsado la puesta en marcha del Plan Nacional de Terapias Avanzadas-Medicamentos CAR-T en España, evidenciándose no solo la conveniencia de identificar los centros más adecuados para su administración, sino la necesidad de que estos sufran una profunda transformación para que su actividad asistencial se extienda en algunos casos a la capacidad de fabricación propia de este tipo de terapias. Los hospitales especializados en hematooncología pediátrica tienen por tanto el reto de evolucionar hacia un modelo asistencial que integre la inmunoterapia celular,dotándose de capacidad propia para gestionar todos los aspectos relativos al uso, fabricación y administración de estos nuevos tratamientos.Fundación CRIS contra el cáncer

La ciudad como experiencia de conocimiento: nuevas metodologías de aprendizaje, iniciación a la investigación y extensión universitaria a partir de la historia urbana

Memoria que recoge las actividades desarolladas en el proyecto de Innovación docente 327 de 2020 con título La ciudad como experiencia de conocimiento: nuevas metodologías de aprendizaje, iniciación a la investigación y extensión universitaria a partir de la historia urbana y dirigido por Rubén Pallol Trigueros

Alanos, vándalos y suevos en la exégesis apocalíptica de Isaac Newton: una fuente y un texto desconocidos

Among Newton's so called non-scientific projects (alchemy and theology), written to a considerable extent in Latin, the interpretation of Revelation stands in a central position. Isaac Newton (1642/3-1727) devoted great efforts to translate Apocalyptical chronology into historical chronology. In this kind of interpretation the wars of the last years of the Roman Empire play an outstanding role, and among them the invasion of Hispania by Alans, Vandals and Suevians. In this paper the author provides new information about the Hispanic sources used by the Cambridge mathematician on the topic, relying on an unpublished passage on the Alans written by Newton in Latin which has gone unnoticed by scholars (National Library of Israel, Yah. Ms. Var. 1 /Newton 19, f. 166r). At the end of this paper the author provides critical edition and Spanish translation of this Latin passage.Peer reviewe

La utilización de la Vulgata en entornos protestantes : una primera aproximación a propósito de las controversias sobre la Trinidad La utilización de la Vulgata en entornos protestantes : una primera aproximación a propósito de las controversias sobre la Trinidad

Peer reviewe

Reseña de "Schilt, Cornelis J. Isaac Newton and the Study of Chronology: Prophecy, History and Method. Amsterdam, Amsterdam University Press, 2021, 309 páginas"

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