Secondary recurrent multiple EGIST of the mesentary: A case report and review of the literature

AbstractINTRODUCTIONGastrointestinal stromal tumors (GISTs) are rare intra-abdominal tumors arising from mesenchymal stromal cells. EGISTs are mesenchymal tumors that originate outside the GI tract and tend to have similar characteristics to GISTs. To the best of our knowledge, few cases of long standing recurrent EGIST have been reported.PRESENTATION OF CASEWe present the case of a rare recurrent EGIST in the mesentery of a 39 year old female patient. The tumor was symptomatic at the time of complaint and measured 8.4cm×7.7cm×7.6cm. Histological analysis revealed a spindled pattern with fusiform cells arranged in long fascicles and little atypia. Immunochemistry showed positivity for CD117 and was negative for CD34, S-100, Desmin, and MSA. B-catenin was weakly positive. A Ki-67 staining shows approximately 5% positivity revealing a low proliferative rate. The patient was doing well postoperatively and was discharged on 400mg imanitib regimen.DISCUSSIONWhile GISTs are the most common tumors of the GI tract, recurrent EGISTs of the mesentery are extremely rare. Factors that indicate poor prognosis include tumor size greater than 5cm, mitotic rate greater than 1–5/10 HPF, presence of tumor necrosis or metastasis and most recently the c-kit mutation. Our patient had a very long time between recurrence of disease.CONCLUSIONThe current literature on EGISTs is limited. Our patient presents a very interesting case due to the time elapsed between disease recurrence and lack of metastasis or excessive growth

Ensayo sobre los Poemas provenzales de los siglos XII y XIII : leido al claustro de la Universidad central

AnteportadaSe ha respetado la puntuación origina

Activation of the Aryl Hydrocarbon Receptor Interferes with Early Embryonic Development.

The transcriptional program of early embryonic development is tightly regulated by a set of well-defined transcription factors that suppress premature expression of differentiation genes and sustain the pluripotent identity. It is generally accepted that this program can be perturbed by environmental factors such as chemical pollutants; however, the precise molecular mechanisms remain unknown. The aryl hydrocarbon receptor (AHR) is a widely expressed nuclear receptor that senses environmental stimuli and modulates target gene expression. Here, we have investigated the AHR interactome in embryonic stem cells by mass spectrometry and show that ectopic activation of AHR during early differentiation disrupts the differentiation program via the chromatin remodeling complex NuRD (nucleosome remodeling and deacetylation). The activated AHR/NuRD complex altered the expression of differentiation-specific genes that control the first two developmental decisions without affecting the pluripotency program. These findings identify a mechanism that allows environmental stimuli to disrupt embryonic development through AHR signaling

Resumen de la historia de las antiguas Cortes de España

Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2009-201

El Coronel, Secretario de este Vireynato, por si, y a nombre de la Secretaria de Camara, contesta el oficio de despedida que con fecha de 31 de mayo de 1816, le circulo el Excmo. Señor Marqués de la Concordia, Virey Gobernador y Capitan General del Peru

Tít. tomado del principio de textoCarta fechada en Lima en 181

La comunidad en relación a la calidad de vida y el papel del educador para la salud

Quality of life is a state of general satisfaction that is determined by factors such as health, housing, interpersonal relationships, the environment, including the community. Depending on how good our relationship with the community is, how developed it is and how satisfied we feel being part of the community can influence people's well-being positively or negatively. Within the development of the community and the improvement of the quality of life is the role and work of the health educator, whose objective is to educate people so that they can develop fully, promote health, improving living conditions. The objective of this article is to make known the influence of the community on the quality of life, the real panorama of the communities at present and the role that the health educator should play in the improvement of the standard of living. To conclude, it should be noted that the quality of life is affected by the determinants of the community, the health educator is very important for the individual and collective well-being of people, a lot of work should be done to improve the communities and the development of the skills of the population. La calidad de vida es un estado de satisfacción general que se ve determinada por factores como la salud, la vivienda, las relaciones interpersonales, el medio ambiente, incluyendo la comunidad. Dependiendo de que tan buena es nuestra relación con la comunidad, que tan desarrollada este y cuan satisfecho nos sintamos formando parte de la comunidad, puede influir en el bienestar de las personas de manera positiva o negativa Dentro del desarrollo de la comunidad y el mejoramiento de la calidad de vida se encuentra el rol y trabajo que ejerce el educador para la salud, cuyo objetivo es el de educar a las personas para que puedan desarrollarse plenamente, promover la salud, mejorando las condiciones de vida.  El objetivo de este artículo es dar a conocer la influencia de la comunidad sobre la calidad de vida, el panorama real de las comunidades en la actualidad y el papel que debe ejercer el educador para la salud en el mejoramiento del nivel de vida. Para finalizar, se debe tener en cuenta que la calidad de vida se ve afectada por los determinantes de la comunidad, en este sentido el educador juega un rol importante para el bienestar individual, colectivo de las personas, se debe trabajar mucho en el mejoramiento de las comunidades y el desarrollo de las habilidades de la población.&nbsp

Método práctico para que los niños y niñas de las provincias tagalas aprendan á hablar castellano : premiado en certamen público por la Direccion gral. de Administracion Civil

Copia digital. España : Ministerio de Cultura y Deporte. Subdirección General de Coordinación bibliotecaria, 2018Tít. en antep.: "Á la íntima y perpetua union de Filipinas à España"Texto paralelo tagalo-españolAntep.Texto a dos col

[Invitaciones a diversas investiduras de licenciado en la facultad de Jurisprudencia]

Título facticio proporcionado por el centro catalogadorVicente de la Fuente fue catedrático de derecho en Salamanca entre 1852 y 1858En la 3ª consta: Imprenta de José Atienz

Mathematical analysis of a low cost mechanical ventilator respiratory dynamics enhanced by a sensor transducer (st) based in nanostructures of anodic aluminium oxide (aao)

Mechanical ventilation systems require a device for measuring the air flow provided to a patient in order to monitor and ensure the correct quantity of air proportionated to the patient, this device is the air flow sensor. At the beginning of the COVID-19 pandemic, flow sensors were not available in Peru because of the international supply shortage. In this context, a novel air flow sensor based on an orifice plate and an intelligent transducer was developed to form an integrated device. The proposed design was focused on simple manufacturing requirements for mass production in a developing country. CAD and CAE techniques were used in the design stage, and a mathematical model of the device was proposed and calibrated experimentally for the measured data transduction. The device was tested in its real working conditions and was therefore implemented in a breathing circuit connected to a low-cost mechanical ventilation system. Results indicate that the designed air flow sensor/transducer is a low-cost complete medical device for mechanical ventilators that is able to provide all the ventilation parameters by an equivalent electrical signal to directly display the following factors: air flow, pressure and volume over time. The evaluation of the designed sensor transducer was performed according to sundry transducer parameters such as geometrical parameters, material parameters and adaptive coefficients in the main transduction algorithm; in effect, the variety of the described results were achieved by the faster response time and robustness proportionated by transducers of nanostructures based on Anodic Aluminum Oxide (AAO), which enhanced the designed sensor/transducer (ST) during operation in intricate geographic places, such as the Andes mountains of Peru