89 research outputs found
Perfil de aloimunização em doadores de sangue no período de janeiro de 2012 a julho de 2015 no Hospital de Clínicas de Porto Alegre
Leucemia linfocítica aguda
This article presents and discusses the case of a 38 year-old black female patient admitted to Hospital das Clínicas de Porto Alegre with fever, weight loss, petechiae, splenomegaly and systolic murmur. The patient received IV cefepime. The results of bone marrow tests were consistent with the diagnosis of pre-B acute lymphocytic leukemia (ALL). The patient received erythrocyte transfusions and chemotherapy with vincristine and daunorubicin. Six days after the admission, the patient presented anxiety and tachypnea. Diazepam 5 mg was administered. The patient had several episodes of cardiorespiratory arrest and died.O artigo apresenta e discute o caso de uma paciente de 38 anos, negra, internada no Hospital de Clínicas de Porto Alegre, apresentando febre, emagrecimento, petéquias, esplenomegalia e sopro sistólico. Foi medicada com cefepime EV. Através do exame de medula óssea, realizou-se o diagnóstico de leucemia linfocítica aguda (LLA) pré-B. A paciente recebeu transfusões de hemácias e quimioterapia com vincristina e daunorubicina. Seis dias após a internação, a paciente apresentava ansiedade e taquipnéia. Recebeu diazepam 5 mg. Sofreu várias paradas cardiorrespiratórias e evoluiu ao óbito
Smoking fewer than 20 cigarettes per day and remaining abstinent for more than 12 hours reduces carboxyhemoglobin levels in packed red blood cells for transfusion
The prevalence of smokers among blood donors and the effect of smoking on the quality of donated blood have not been extensively explored. In the present study, we determined the prevalence of smoker donors in a large blood bank in Southern Brazil and evaluated the quality of packed red blood cells (RBCs) from these donors through recommended quality control tests and measurement of carboxyhemoglobin (COHb) levels. We then assessed the influence of smoking habits and abstinence before donation on these parameters. Material and methods An observational study was conducted to determine the prevalence of smoking donors, while a prospective cohort study compared conventional hematological and serological parameters and COHb levels at 0, 15, and 30 days after donation in RBCs donated by smokers (N = 31) and nonsmokers (N = 31) and their association with smoking habits and abstinence before donation. Results Of 14,428 blood donations received in 1 year, 5.9% were provided by smokers. Storage over time slightly altered some quality parameters, such as hematocrit, hemoglobin, hemolysis, and COHb levels, in RBC packs. COHb levels were higher in RBC packs from smokers (8%) than from non-smokers (2%), and increased as a function of the number of cigarettes smoked daily and time elapsed since the last cigarette smoked before donation. Lower levels were found in RBC packs from donors who smoked fewer than 20 cigarettes per day or remained abstinent for more than 12h before giving blood. Conclusion Although cigarette smoke had no significant effect on blood quality parameters such as hematocrit, hemoglobin, or hemolysis, it quadrupled COHb levels in packed RBCs. Abstinence from smoking for more than 12h or smoking fewer than 20 cigarettes daily helped decrease COHb levels. Implications Given the increasing prevalence of tobacco use worldwide, we suggest blood banks recommend 12h of tobacco abstinence before donation and analyze COHb levels in donated blood as an approach to reduce risk for high-risk recipients
Perfil dos doadores de sangue com sorologia reagente para doença de chagas : análise de 2005 a 2015
Dano ao DNA na hemocromatose hereditária : correlações com desfechos clínicos e genótipos HFE
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