Clinical Relevance of Corticosteroid Withdrawal on Graft Histological Lesions in Low-Immunological-Risk Kidney Transplant Patients

The impact of corticosteroid withdrawal on medium-term graft histological changes in kidney transplant (KT) recipients under standard immunosuppression is uncertain. As part of an open-label, multicenter, prospective, phase IV, 24-month clinical trial (ClinicalTrials.gov, NCT02284464) in low-immunological-risk KT recipients, 105 patients were randomized, after a protocol-biopsy at 3 months, to corticosteroid continuation (CSC, n = 52) or corticosteroid withdrawal (CSW, n = 53). Both groups received tacrolimus and MMF and had another protocol-biopsy at 24 months. The acute rejection rate, including subclinical inflammation (SCI), was comparable between groups (21.2 vs. 24.5%). No patients developed dnDSA. Inflammatory and chronicity scores increased from 3 to 24 months in patients with, at baseline, no inflammation (NI) or SCI, regardless of treatment. CSW patients with SCI at 3 months had a significantly increased chronicity score at 24 months. HbA1c levels were lower in CSW patients (6.4 +/- 1.2 vs. 5.7 +/- 0.6%; p = 0.013) at 24 months, as was systolic blood pressure (134.2 +/- 14.9 vs. 125.7 +/- 15.3 mmHg; p = 0.016). Allograft function was comparable between groups and no patients died or lost their graft. An increase in chronicity scores at 2-years post-transplantation was observed in low-immunological-risk KT recipients with initial NI or SCI, but CSW may accelerate chronicity changes, especially in patients with early SCI. This strategy did, however, improve the cardiovascular profiles of patients

El sistema HLA en el asma, asociación del genotivo DRB *01-DQB1*0501 con el asma alérgico a "artemisa vulgaris" / Alberto Torio Ruiz ; directores María Rocío Alvarez López, Manuel Muro Amador.

Tesis-Universidad de Murcia.Consulte la tesis en: BCA. GENERAL. ARCHIVO UNIVERSITARIO. T.M. 2640

5th International Conference on Technological Ecosystems for Enhancing Multiculturality (TEEM 2017)

Google Classroom (GC) is gaining momentum in the educational milieu, but its functionalities are limited. Learning analytics applications integrated with GC can help to face these limitations, but to reach this aim, developers need access to the data generated by GC’s users. This paper reports on the results of an analysis of the existing alternatives to collect data from GC. The study is based on the analysis of the documentation provided by the involved tools. The analysis shows that GC’s API is a potential source of data about the activity of the users in GC-enabled settings, but that the information it provides is limited. Further work is needed to explore if Chrome OS synchronization functions can deliver more detailed information about GC usage, thus enabling for more advanced learning analytics applications.Ministerio de Economía, Industria y Competitividad (Projects TIN2014-53199-C3-2-R and TIN2015-71669-REDT)Junta de Castilla y León (programa de apoyo a proyectos de investigación - Ref. VA082U16