Prasugrel versus Clopidogrel for Acute Coronary Syndromes without Revascularization

peer reviewedBACKGROUND: The effect of intensified platelet inhibition for patients with unstable angina or myocardial infarction without ST-segment elevation who do not undergo revascularization has not been delineated. METHODS: In this double-blind, randomized trial, in a primary analysis involving 7243 patients under the age of 75 years receiving aspirin, we evaluated up to 30 months of treatment with prasugrel (10 mg daily) versus clopidogrel (75 mg daily). In a secondary analysis involving 2083 patients 75 years of age or older, we evaluated 5 mg of prasugrel versus 75 mg of clopidogrel. RESULTS: At a median follow-up of 17 months, the primary end point of death from cardiovascular causes, myocardial infarction, or stroke among patients under the age of 75 years occurred in 13.9% of the prasugrel group and 16.0% of the clopidogrel group (hazard ratio in the prasugre

Mesh-guided lego model synthesis

We propose a polygonal approximation that will use a 3D mesh to guide the user in building 3D Lego models. Lego model building is a popular activity to children and adults alike as it is considered an intellectual activity that enhances people’s creativity. However, building Lego models from scratch demands skill, creativity and experience regardless of whether real Lego bricks of Lego CAD’s will be used. Conceptualization also plays a vital role in the building process, and may pose great difficulty on the part of the builder, especially when the model is very large and complicated. One approach in handling this problem is by developing a system that allows users to build their Lego models with the help of a guide. With the use of polygonal approximation on the meshes, a guide will be constructed with respect to the Lego bricks imported from Lego parts library. It will specify the mesh structure. The Lego Bricks will be imported from a Lego parts library and the mesh will be structured in the form of the imported Lego brick