Association of Three Polymorphisms rs11614913, rs2910146, and rs3746444 in miRNA-196a2, miRNA-146a, and miRNA-499 with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

Background. It has been found that single-nucleotide polymorphisms (SNPs) of microRNA might be involved in the development of inflammatory bowel diseases (IBDs). However, the related retrospective research has not been reported. In this work, we performed a meta-analysis to derive a more precise estimation of the associated relationship. Methods. We searched the studies on the association of SNPs of microRNA with the hereditary susceptibility of IBD in PubMed and Embase; eligible research was selected by screening the abstract and full text. The meta-analysis was performed based on the statistical software Stata 14.0, and besides, the odds ratio and 95% confidence interval were calculated to evaluate the strength of the association. Results. 159 papers were acquired from the PubMed and Embase databases, and five eligible articles containing nine case-control studies were selected. In the study, we first found that the association between miRNA-196a2 rs11614913 and IBD was insignificant. Then, the susceptibility of miRNA-146a rs2910146 to IBD increased significantly in allelic comparison, homozygote model, heterozygote model, and dominant model. Moreover, a positive relationship between miRNA-499 rs3746444 and IBD was identified in the homozygote model. Conclusion. Our findings demonstrated that miRNA-146a rs2910146 (G>C) polymorphism was associated with the susceptibility to IBD and miRNA-196a2 rs11614913 (T>C) and miRNA-499 rs3746444 (A>G) did not reveal an obvious relationship with the IBD susceptibility

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Effects of Substitute Substrate, Water, and Fertilizer Management on the Growth of Potted Chrysanthemums

The chrysanthemum is a perennial herbaceous flower with a long history of cultivation dating back over 3000 years. The potted chrysanthemum is a significant type and is widely used in landscaping. Expensive substrate costs, complicated management of water and fertilizer, and uneven product quality currently plague the potted chrysanthemum industry. This study systematically investigated the growth status of potted chrysanthemums under different substrates, water, and fertilizer ratios and established a simplified cultivation system for potted chrysanthemums. The substitute substrate experiment demonstrated that coir: moss peat: perlite: pine needle mulch = 2:4:2:2 is the most suitable substitute substrate. Research on fertilizer ratios found that chrysanthemums’ best growth and flowering characteristics were achieved with nitrogen, phosphorus, and potassium concentrations of 336 mg/L, 93 mg/L, and 273 mg/L, respectively. A comprehensive, simplified cultivation system was established when utilizing T4 substitute substrate (2:4:2:2 ratios of coir, moss peat, perlite, and pine needle mulch), 40% water capacity, and F9 fertilizer (336 mg/L nitrogen, 93 mg/L phosphorus, and 273 mg/L potassium). This study comprehensively and systematically explored the cultivation and maintenance schemes in the production of potted chrysanthemums and built a light, simple, and efficient production technology system of potted chrysanthemums in the open field suitable for the climatic characteristics of northern China, which provides feasible technical specifications and a theoretical basis for the refinement and large-scale management of potted chrysanthemums. This experiment lays the foundations for cost reduction and efficiency in the potted chrysanthemum industry