Relationship between sleep duration and clustering of metabolic syndrome diagnostic components

Sayuri Katano1, Yasuyuki Nakamura1,2, Aki Nakamura1, Yoshitaka Murakami3, Taichiro Tanaka4, Toru Takebayashi5, Akira Okayama6, Katsuyuki Miura2, Tomonori Okamura7, Hirotsugu Ueshima2, for HIPOP-OHP Research Group1Cardiovascular Epidemiology, Kyoto Women's University, Kyoto, Japan; 2Department of Health Science, Shiga University of Medical Science, Otsu, Japan; 3Department of Medical Statistics, Shiga University of Medical Science, Otsu, Japan; 4Department of Health Sciences, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Japan; 5Department of Preventive Medicine and Public Health, School of Medicine, Keio University, Tokyo, Japan; 6The First Institute of Health Service, Japan Anti-Tuberculosis Association, Tokyo, Japan; 7Department of Preventive Cardiology, National Cardiovascular Center, Suita, JapanObjective: To examine the relation between sleep duration and metabolic syndrome (MetS).Methods: We examined the baseline data from 4356 healthy workers (3556 men and 800 women) aged 19–69 years. The physical activity of each participant was classified according to the International Physical Activity Questionnaire (IPAQ). We defined four components of MetS diagnostic components in this study as follows: 1) high blood pressure (BP) systolic BP [SBP] ≥ 130 mmHg, or diastolic BP [DBP] ≥ 85 mmHg, or on medication; 2) dyslipidemia (high-density lipoprotein-cholesterol concentration ,40 mg/dL, or triglycerides concentration ≥150 mg/dL, or on medication; 3) impaired glucose tolerance (fasting blood sugar concentration ≥ 110 mg/dL, or if less than 8 hours after meals ≥ 140 mg/dL), or on medication; and 4) overweight (body mass index [BMI] ≥ 25 kg/m2), or obesity (BMI ≥ 30 kg/m2). There were 680 participants in the group, with sleep duration <6 hours (15.6%).Results: Those who had 0–4 MetS diagnostic components, including overweight, accounted for 2159, 1222, 674, 255, and 46 participants, respectively, in the Poisson distribution. Poisson regression analysis revealed that independent factors that contributed to the number of MetS diagnostic components were being male (regression coefficient b = 0.752, P < 0.001), age (b = 0.026, P < 0.001), IPAQ classification (b = -0.238, P = 0.034), and alcohol intake (mL/day) (b = 0.018, P < 0.001). Short sleep duration (<6 hours) was also related to the number of MetS (b = 0.162, P < 0.001). The results of analyses with obesity component showed a similar association.Conclusion: Short sleep duration was positively associated with the number of MetS diagnostic components independent of other lifestyle habits.Keyword: short sleep duration, MetS diagnostic components, obesit

Impairments in Activities of Daily Living in Older Japanese Men in Hawaii and Japan

Introduction. Hypertension and cigarette smoking are dominant risk factors for cardiovascular disease in Japan while in westernized countries, broader effects encompass obesity, diabetes, and hypercholesterolemia. This paper examines whether different associations also appear important in the manifestation of activities of daily living (ADL) in older Japanese men in Hawaii and Japan. Methods. Measures of ADL (feeding, toileting, dressing, bathing, and walking around the house) were assessed from 1995 to 1999 in 1,893 men in Hawaii and 543 men in Japan. Concomitant risk factors were measured from 1990 to 1993. Results. In Hawaii, diabetes increased the odds of ≥1 ADL impairment nearly 1.5-fold (P = .020). A similar association was absent in Japan. In contrast, the odds of an ADL impairment in Japan was increased more than 5-fold in the presence of stroke (P < .001). The association in Hawaii was significantly weaker (P = .007). In both cohorts, past alcohol use was associated with a greater likelihood of ADL impairment. Conclusion. In this comparison of genetically similar samples, findings suggest that different strengths in risk factor associations with cardiovascular disease in Japan and westernized countries may also include different strengths in associations with impaired ADL

Intracluster Short Gamma-Ray Bursts by Compact Binary Mergers

One of the possible origins of short gamma-ray bursts (SGRBs) is merging of compact binaries, and the effect of large kick velocity is a signature that can be used as an observational test for this hypothesis. Intracluster SGRBs that escaped from a host galaxy in a galaxy cluster are interesting in this context, since they would escape more easily by cluster tidal force, and would have brighter afterglow luminosity by dense intracluster gas, than those in general field galaxies. Here we calculate the escape fraction of compact binaries from their host galaxies in a galaxy cluster, and discuss some observational implications. We found that the escape fraction strongly depends on the nature of dark matter subhalos associated with member galaxies. If the amount of dark matter around member galaxies is not large and the gravitational potential for an escaping binary is determined mostly by stellar mass, most of SGRBs should escape and be observed as hostless, which is a much higher fraction than those in the field. Hence, statistics of intracluster SGRBs could give important information about the dark matter distribution in galaxy clusters, as well as hints for the origin of SGRBs.Comment: 6 pages, 1 figure, accepted to ApJ Letters; added discussion about evolution of galaxies and cluster

国民の代表集団による高齢者のADL、生活の質低下の予防に関するコホート研究:NIPPON DATA

厚生労働科学研究費補助金研究成果報告書研究区分: 厚生科学研究費補助金 総合的プロジェクト研究分野 長寿科学総合研究事業研究年度: 2001報告書区分: 総括文献番号: 200100214A研究代表者: 上島 弘嗣（滋賀医科大学・医学部・教授）研究分担者: 岡村 智教（滋賀医科大学・医学部・助教授

The Relationship Between Asian Dust Events and Out-of-Hospital Cardiac Arrests in Japan

Background: Asian dust events are caused by dust storms that originate in the deserts of China and Mongolia and drift across East Asia. We hypothesized that the dust events would increase incidence of out-of-hospital cardiac arrests by triggering acute events or exacerbating chronic diseases.Methods: We analyzed the Utstein-Style data collected in 2005 to 2008 from seven prefectures covering almost the entire length of Japan to investigate the effect of Asian dust events on out-of-hospital cardiac arrests. Asian dust events were defined by the measurement of light detection and ranging. A time-stratified case-crossover analysis was performed. The strength of the association between Asian dust events and out-of-hospital cardiac arrests was shown by odds ratios and 95% confidence intervals in two conditional logistic models. A pooled estimate was obtained from area-specific results by random-effect meta-analysis.Results: The total number of cases of out-of-hospital cardiac arrest was 59 273, of which 35 460 were in men and 23 813 were in women. The total number of event days during the study period was smallest in Miyagi and Niigata and largest in Shimane and Nagasaki. There was no significant relationship between Asian dust events and out-of-hospital cardiac arrests by area in either of the models. In the pooled analysis, the highest odds ratios were observed at lag day 1 in both model 1 (OR 1.07; 95% CI, 0.97?1.19) and model 2 (OR 1.08; 95% CI, 0.97?1.20). However, these results were not statistically significant.Conclusions: We found no evidence of an association between Asian dust events and out-of-hospital cardiac arrests

Imaging analysis reveals mechanistic differences between first- and second-phase insulin exocytosis

The mechanism of glucose-induced biphasic insulin release is unknown. We used total internal reflection fluorescence (TIRF) imaging analysis to reveal the process of first- and second-phase insulin exocytosis in pancreatic β cells. This analysis showed that previously docked insulin granules fused at the site of syntaxin (Synt)1A clusters during the first phase; however, the newcomers fused during the second phase external to the Synt1A clusters. To reveal the function of Synt1A in phasic insulin exocytosis, we generated Synt1A-knockout (Synt1A−/−) mice. Synt1A−/− β cells showed fewer previously docked granules with no fusion during the first phase; second-phase fusion from newcomers was preserved. Rescue experiments restoring Synt1A expression demonstrated restoration of granule docking status and fusion events. Inhibition of other syntaxins, Synt3 and Synt4, did not affect second-phase insulin exocytosis. We conclude that the first phase is Synt1A dependent but the second phase is not. This indicates that the two phases of insulin exocytosis differ spatially and mechanistically

Relationship between Dietary and Other Lifestyle Habits and Cardiometabolic Risk Factors in Men

<p>Abstract</p> <p>Background</p> <p>Prevalence of men with cardiometabolic risk factors (CMRF) is increasing in Japan. Few studies have comprehensively examined the relation between lifestyles and CMRF.</p> <p>Methods</p> <p>We examined the baseline data from 3,498 male workers ages 19 to 69 years who participated in the high-risk and population strategy for occupational health promotion (HIPOP-OHP) study at 12 large-scale companies throughout Japan. The physical activity of each participant was classified according to the International Physical Activity Questionnaire (IPAQ). Dietary intake was surveyed by a semi-quantitative Food Frequency Questionnaire. We defined four CMRF in this study as follows: 1) high blood pressure (BP): systolic BP ≥ 130 mmHg, or diastolic BP ≥ 85 mmHg, or the use of antihypertensive drugs; 2) dyslipidemia: high-density lipoprotein-cholesterol concentration < 40 mg/dl, or triglycerides concentration ≥ 150 mg/dl, or on medication for dyslipidemia; 3) impaired glucose tolerance: fasting blood sugar concentration ≥110 mg/dl; 4) obese: a body mass index ≥ 25 kg/m².</p> <p>Results</p> <p>Those who had 0 to 4 CMRF accounted for 1,597 (45.7%), 1,032 (29.5%), 587 (16.8%), 236 (6.7%), and 44 (1.3%) participants, respectively, in the Poisson distribution. Poisson regression analysis revealed that independent factors that contributed to the number of CMRF were age (b = 0.020, P < 0.01), IPAQ (b = -0.091, P < 0.01), alcohol intake (ml/day) (b = 0.001, P = 0.03), percentage of protein intake (b = 0.059, P = 0.01), and total energy intake (kcal)(b = 0.0001, P < 0.01). Furthermore, alcohol intake and its frequency had differential effects.</p> <p>Conclusions</p> <p>Alcohol intake, percent protein and total energy intake were positively associated, whereas drinking frequency and IPAQ were inversely associated, with the number of CMRF.</p

青・壮年者を対象とした生活習慣病予防のための長期介入研究

厚生科学研究費補助金研究成果報告書厚生労働科学研究費補助金 効果的医療技術の確立推進臨床研究事業研究年度: 2001～2003報告書区分: 総合主任研究者: 上島 弘嗣（滋賀医科大学・医学部・教授）分担研究者: 岡村 智教（滋賀医科大学・医学部・助教授）分担研究者: 中村 保幸（滋賀医科大学・医学部・助教授

青・壮年者を対象とした生活習慣病予防のための長期介入研究

厚生労働科学研究費補助金研究成果報告書研究区分: 厚生労働科学研究費補助金 総合的プロジェクト研究分野 効果的医療技術の確立推進臨床研究（生活習慣病分野）研究年度: 2002報告書区分: 総括文献番号: 200200533A主任研究者: 上島 弘嗣（滋賀医科大学・医学部・教授）分担研究者: 岡村 智教（滋賀医科大学・医学部・助教授）分担研究者: 中村 保幸（滋賀医科大学・医学部・助教授

青・壮年者を対象とした生活習慣病予防のための長期介入研究

厚生労働科学研究費補助金研究成果報告書研究区分: 厚生労働科学研究費補助金 総合的プロジェクト研究分野 効果的医療技術の確立推進臨床研究（生活習慣病分野）研究年度: 2003報告書区分: 総括文献番号: 200300461A主任研究者: 上島 弘嗣（滋賀医科大学・医学部・教授）分担研究者: 岡村 智教（滋賀医科大学・医学部・助教授）分担研究者: 中村 保幸（滋賀医科大学・医学部・助教授