Robot arm system for automatic satellite capture and berthing

Load control is one of the most important technologies for capturing and berthing free flying satellites by a space robot arm because free flying satellites have different motion rates. The performance of active compliance control techniques depend on the location of the force sensor and the arm's structural compliance. A compliance control technique for the robot arm's structural elasticity and a consideration for an end-effector appropriate for it are presented in this paper

Marine Sediment Characterized by Ocean‐Bottom Fiber‐Optic Seismology

The Sanriku ocean‐bottom seismometer system uses an optical fiber cable to guarantee real‐time observations at the seafloor. A dark fiber connected to a Distributed Acoustic Sensing (DAS) interrogator converted the cable in an array of 19,000 seismic sensors. We use these measurements to constrain the velocity structure under a section of the cable. Our analysis relies on 24 hr of ambient seismic field recordings. We obtain a high‐resolution 2‐D shear‐wave velocity profile by inverting multimode dispersion curves extracted from frequency‐wave number analysis. We also produce a reflection image from autocorrelations of ambient seismic field, highlighting strong impedance contrasts at the interface between the sedimentary layers and the basement. In addition, earthquake wavefield analysis and modeling help to further constrain the sediment properties under the cable. Our results show for the first time that ocean‐bottom DAS can produce detailed images of the subsurface, opening new opportunities for cost‐effective ocean‐bottom imaging in the future.Plain Language SummaryDistributed Acoustic Sensing (DAS) is a relatively new measurement method that has the potential to convert existing fiber optic communication infrastructure into arrays of thousands of seismic sensors. In this research, we connected a DAS to a cable that was originally installed at the bottom of the ocean to sustain a seismic and tsunami observatory in the Sanriku Region. We show that this new type of measurement can provide reliable information to image and explore the shallow subsurface under this fiber cable. This is the first time such analysis is performed in an oceanic environment, and our methods could be readily exportable to other fiber‐optic cables that are the backbones of our modern telecommunication.Key PointsOcean‐bottom Distributed Acoustic Sensing is used to image shallow VS structureRayleigh wave phase velocity dispersion curves are extracted from frequency‐wave number analysisReflection image is obtained from autocorrelations of ambient seismic fieldPeer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/156494/3/grl61098_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/156494/2/grl61098.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/156494/1/grl61098-sup-0001-2020GL088360-Text_SI-S01.pd

Idiopathic Chondrolysis of the Hip Treated by Immunosuppressive Therapy and Arthroscopic Intervention

Idiopathic chondrolysis of the hip (ICH), a very rare disorder of unknown etiology, occurs mainly in female adolescents. Characterized by pain, limp, stiffness and radiological narrowing joint space from the rapid destruction of the articular cartilage, ICH sometimes results in ankyloses. We present the case of a 10-year-old girl diagnosed with ICH based on arthroscopic inspection and synovium biopsy. The femoral deformity appeared gradually, like a cam-type femoroacetabular impingement. She was treated with intensive rehabilitation and immunosuppressive drug. We later performed an arthroscopic bumpectomy for residual symptoms. She achieved a favorable outcome as a 15-year-old at the latest follow-up

Optical coherence tomography angiography in eyes with good visual acuity recovery after treatment for optic neuritis.

To evaluate the retinal perfusion using optical coherence tomography (OCT) angiography in eyes with good visual acuity recovery after treatment for optic neuritis (ON).Seven eyes of seven patients with good visual acuity recovery after treatment for monocular ON and seven eyes of each fellow eye used as controls were studied. Retinal perfusion around the disc and at the macula was evaluated using OCT angiography. The retinal nerve fiber layer thickness was measured around the disc. The ganglion cell layer complex thickness or the ganglion cell layer plus the inner plexiform layer thickness were measured at the macula.The retinal perfusions in all eyes with ON decreased around the disc and at the macula compared with those of the fellow eyes, as shown by OCT angiography (disc, P = 0.003; macula, P = 0.001). The retinal thicknesses in all eyes with ON also decreased around the disc and at the macula compared with those of the fellow eyes (disc, P < 0.001; macula, P = 0.003).Optic neuritis may cause not only retinal structural damage but also decreased retinal perfusion, even after the visual acuity recovered well after treatment

Secure and effective gene delivery system of plasmid DNA coated by polynucleotide

Polynucleotides are anionic macromolecules which are expected to transfer into the targeted cells through specific uptake mechanisms. So, we developed polynucleotides coating complexes of plasmid DNA (pDNA) and polyethylenimine (PEI) for a secure and efficient gene delivery system and evaluated their usefulness. Polyadenylic acid (polyA), polyuridylic acid (polyU), polycytidylic acid (polyC), and polyguanylic acid (polyG) were examined as the coating materials. pDNA/PEI/polyA, pDNA/PEI/polyU, and pDNA/PEI/polyC complexes formed nanoparticles with a negative surface charge although pDNA/PEI/polyG was aggregated. The pDNA/PEI/polyC complex showed high transgene efficiency in B16-F10 cells although there was little efficiency in pDNA/PEI/polyA and pDNA/PEI/polyU complexes. An inhibition study strongly indicated the specific uptake mechanism of pDNA/PEI/polyC complex. Polynucleotide coating complexes had lower cytotoxicity than pDNA/PEI complex. The pDNA/PEI/polyC complex showed high gene expression selectively in the spleen after intravenous injection into mice. The pDNA/PEI/polyC complex showed no agglutination with erythrocytes and no acute toxicity although these were observed in pDNA/PEI complex. Thus, we developed polynucleotide coating complexes as novel vectors for clinical gene therapy, and the pDNA/PEI/polyC complex as a useful candidate for a gene delivery system

Development of Kupffer cell targeting type-I interferon for the treatment of hepatitis via inducing anti-inflammatory and immunomodulatory actions

Because of its multifaceted anti-inflammatory and immunomodulatory effects, delivering type-I interferon to Kupffer cells has the potential to function as a novel type of therapy for the treatment of various types of hepatitis. We report herein on the preparation of a Kupffer cell targeting type-I interferon, an albumin-IFNα2b fusion protein that contains highly mannosylated N-linked oligosaccharide chains, Man-HSA(D494N)-IFNα2b, attached by combining albumin fusion technology and site-directed mutagenesis. The presence of this unique oligosaccharide permits the protein to be efficiently, rapidly and preferentially distributed to Kupffer cells. Likewise IFNα2b, Man-HSA(D494N)-IFNα2b caused a significant induction in the mRNA levels of IL-10, IL-1Ra, PD-L1 in RAW264.7 cells and mouse isolated Kupffer cells, and these inductions were largely inhibited by blocking the interferon receptor. These data indicate that Man-HSA(D494N)-IFNα2b retained the biological activities of type-I interferon. Man-HSA(D494N)-IFNα2b significantly inhibited liver injury in Concanavalin A (Con-A)-induced hepatitis model mice, and consequently improved their survival rate. Moreover, the post-administration of Man-HSA(D494N)-IFNα2b at 2 h after the Con-A challenge also exerted hepato-protective effects. In conclusion, this proof-of-concept study demonstrates the therapeutic effectiveness and utility of Kupffer cell targeting type-I interferon against hepatitis via its anti-inflammatory and immunomodulatory actions