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The relationship between poverty and childhood well-being in Great Britain
Trends in social capital: Membership of associations in Great Britain, 1991–98
This Note uses the British Household Panel Study (BHPS) to consider the changing volume and distribution of voluntary association membership (and hence social capital) in Great Britain. We aim to supplement Hall's study of trends in social capital published in this Journal with more recent and longitudinal data. This allows us to show that whilst the volume of social capital is not declining, it is becoming increasingly class specific, and that its relative aggregate stability masks considerable turnover at the individual level. These findings are significant for current debates on social capital
Computational Simulation and 3D Virtual Reality Engineering Tools for Dynamical Modeling and Imaging of Composite Nanomaterials
An adventure at engineering design and modeling is possible with a Virtual
Reality Environment (VRE) that uses multiple computer-generated media to let a
user experience situations that are temporally and spatially prohibiting. In
this paper, an approach to developing some advanced architecture and modeling
tools is presented to allow multiple frameworks work together while being
shielded from the application program. This architecture is being developed in
a framework of workbench interactive tools for next generation
nanoparticle-reinforced damping/dynamic systems. Through the use of system, an
engineer/programmer can respectively concentrate on tailoring an engineering
design concept of novel system and the application software design while using
existing databases/software outputs.Comment: Submitted on behalf of TIMA Editions
(http://irevues.inist.fr/tima-editions
Dry Friction due to Adsorbed Molecules
Using an adiabatic approximation method, which searches for Tomlinson
model-like instabilities for a simple but still realistic model for two
crystalline surfaces in the extremely light contact limit, with mobile
molecules present at the interface, sliding relative to each other, we are able
to account for the virtually universal occurrence of "dry friction." The model
makes important predictions for the dependence of friction on the strength of
the interaction of each surface with the mobile molecules.Comment: four pages of latex, figure provide
Superlubricity - a new perspective on an established paradigm
Superlubricity is a frictionless tribological state sometimes occurring in
nanoscale material junctions. It is often associated with incommensurate
surface lattice structures appearing at the interface. Here, by using the
recently introduced registry index concept which quantifies the registry
mismatch in layered materials, we prove the existence of a direct relation
between interlayer commensurability and wearless friction in layered materials.
We show that our simple and intuitive model is able to capture, down to fine
details, the experimentally measured frictional behavior of a hexagonal
graphene flake sliding on-top of the surface of graphite. We further predict
that superlubricity is expected to occur in hexagonal boron nitride as well
with tribological characteristics very similar to those observed for the
graphitic system. The success of our method in predicting experimental results
along with its exceptional computational efficiency opens the way for modeling
large-scale material interfaces way beyond the reach of standard simulation
techniques.Comment: 18 pages, 7 figure
Elevating crop disease resistance with cloned genes
Essentially all plant species exhibit heritable genetic variation for resistance to a variety of plant diseases caused by fungi, bacteria, oomycetes or viruses. Disease losses in crop monocultures are already significant, and would be greater but for applications of disease-controlling agrichemicals. For sustainable intensification of crop production, we argue that disease control should as far as possible be achieved using genetics rather than using costly recurrent chemical sprays. The latter imply CO2 emissions from diesel fuel and potential soil compaction from tractor journeys. Great progress has been made in the past 25 years in our understanding of the molecular basis of plant disease resistance mechanisms, and of how pathogens circumvent them. These insights can inform more sophisticated approaches to elevating disease resistance in crops that help us tip the evolutionary balance in favour of the crop and away from the pathogen. We illustrate this theme with an account of a genetically modified (GM) blight-resistant potato trial in Norwich, using the Rpi-vnt1.1 gene isolated from a wild relative of potato, Solanum venturii, and introduced by GM methods into the potato variety Desiree
Static and Dry Friction due to Multiscale Surface Roughness
It is shown on the basis of scaling arguments that a disordered interface
between two elastic solids will quite generally exhibit static and "dry
friction" (i.e., kinetic friction which does not vanish as the sliding velocity
approaches zero), because of Tomlinson model instabilities that occur for small
length scale asperities. This provides a possible explanation for why static
and "dry" friction are virtually always observed, and superlubricity almost
never occurs
11 beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle
OBJECTIVE: Glucocorticoid excess is characterized by increased adiposity, skeletal myopathy, and insulin resistance, but the precise molecular mechanisms are unknown. Within skeletal muscle, 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) converts cortisone (11-dehydrocorticosterone in rodents) to active cortisol (corticosterone in rodents). We aimed to determine the mechanisms underpinning glucocorticoid-induced insulin resistance in skeletal muscle and indentify how 11beta-HSD1 inhibitors improve insulin sensitivity. \ud
RESEARCH DESIGN AND METHODS: Rodent and human cell cultures, whole-tissue explants, and animal models were used to determine the impact of glucocorticoids and selective 11beta-HSD1 inhibition upon insulin signaling and action. \ud
RESULTS: Dexamethasone decreased insulin-stimulated glucose uptake, decreased IRS1 mRNA and protein expression, and increased inactivating pSer insulin receptor substrate (IRS)-1. 11beta-HSD1 activity and expression were observed in human and rodent myotubes and muscle explants. Activity was predominantly oxo-reductase, generating active glucocorticoid. A1 (selective 11beta-HSD1 inhibitor) abolished enzyme activity and blocked the increase in pSer IRS1 and reduction in total IRS1 protein after treatment with 11DHC but not corticosterone. In C57Bl6/J mice, the selective 11beta-HSD1 inhibitor, A2, decreased fasting blood glucose levels and improved insulin sensitivity. In KK mice treated with A2, skeletal muscle pSer IRS1 decreased and pThr Akt/PKB increased. In addition, A2 decreased both lipogenic and lipolytic gene expression.\ud
CONCLUSIONS: Prereceptor facilitation of glucocorticoid action via 11beta-HSD1 increases pSer IRS1 and may be crucial in mediating insulin resistance in skeletal muscle. Selective 11beta-HSD1 inhibition decreases pSer IRS1, increases pThr Akt/PKB, and decreases lipogenic and lipolytic gene expression that may represent an important mechanism underpinning their insulin-sensitizing action
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