Developmental aspects of innovation in preschool education

This work is based on the modern institutional concept of the preschool physical education programme, which is realized in the kindergarten 'Sunce' courtyard, in the preschool institution 'Jelica Obradović' in Mladenovac. Namely, in the courtyard of the mentioned kindergarten, an innovative system for physical exercise named 'Sun's Playroom - Planetary Polygon' was constructed and installed. Two groups of children of the same age, with different motor experiences, were practicing daily for 30 minutes, on the mentioned system, for 20 days. An assessment of children's motor skills on the given system was performed at the beginning and at the end of the cycle. In addition to the assessment of motor skills and the control level over motor functions, the cognitive process of information acquisition and the level of communication and socialization among children were also monitored. The conclusion reached is that this kind of a new complex for exercise and learning in the open space has a significant impact on the development of psycho-motorics in children, as well as on the cognitive functions, cultural and communication skills

Reduction of Trihalomethanes Forming Potential by Adsorption of Natural Organic Matter on Ionic Exchange Resins

In a sanitation process of drinking water, carbon from the organic matter reacts with chlorine, forming by-products, among which are trihalomethanes (THM). These substances are carriers of mutagenic and can-cerogenic potential and hence should be removed in drinking water treatment. Since the natural organic mat-ters are precursors of THM formation, their removal from the water decreases the concentration of THMs. The THM forming potential is the most reliable indicator in evaluation of organic matter removal during drinking water treatment processes. The results have shown that the reaction producing THMs follows sec-ond order kinetics. The second order rate constant ranged from 0.024 M-1s-1 to 0.065 M-1s-1 at 22 °C and pH = 8.2 for 96 hours. The removal of 78.4% of natural organic matter, by adsorption on anionic exchange res-ins, resulted in the THM forming potential reduction by 63.1%. Various fractions of natural organic matter differ in their reactivity with chlorine, which is important when it comes to selection of the adsorption me-dium in the drinking water treatment processes

Study toward resolving the controversy over the definition of allergic fungal rhinosinusitis

Dysbiosis of the microbiome on the airway mucosa leads to the development of chronic inflammatory and allergic disorders. The aim of this study was to consider the potential diagnostic criteria for allergic fungal rhinosinusitis (AFRS) and nonallergic fungal rhinosinusitis (FRS), and the role of fungal presence in an environment for the development of AFRS. In this study, 136 patients were divided into two groups: patients with positive specific immunoglobulin E (sIgE) and fungal finding (AFRS group), and patients with negative sIgE and positive fungal finding (FRS group). The study design included: anamnesis data, sIgE, eosinophil count and skin-prick test, rhinology and computerized tomography (CT) observation and mycological finding. Our results showed: (i) the prevalence in Serbia is: AFRS 1.3%, FRS 2.8%; (ii) 30.4% patients with sIgE+ had more often severe and recurrent chronic rhinosinusitis (CRS) (P = .005) and the presence of polyps (P = .025); (iii) 46.4% patients with sIgE+ had positive fungi on the sinonasal mucosa and were considered as AFRS; (iv) patients with AFRS had more frequent asthma (P = .024) and chronicity of CRS > 10 years (P = .000). The persistent fungal presence and prolonged duration of CRS could be a silent threat for the progression of inflammation and development of FRS. Lavage with hypertonic-NaCl should be included in the everyday hygiene routine in an effort to decrease fungal load and antigenic exposure. The presence of allergological parameters and better response to corticosteroid therapy in AFRS patients should be considered as crucial diagnostic criteria for AFRS

Supplementary data for article: Novakovic, M.; Bukvicki, D.; Andjelkovic, B.; Ilic-Tomic, T.; Veljic, M.; Tesevic, V.; Asakawa, Y. Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia Cruciata. Journal of Natural Products 2019, 82 (4), 694–701. https://doi.org/10.1021/acs.jnatprod.8b00390

Supporting information for: [https://doi.org/10.1021/acs.jnatprod.8b00390]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/3096

Supporting information for: "Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia cruciata"

NMR spectra of the isolated compounds and additional figures and tables. Table S1. Elution Program for the Silica Gel Column Separation; Figure S1. Aromatic part of the 1H NMR spectrum of compound 1;This is the Supporting information for the article: Novaković, M., Bukvicki, D., Anđelković, B. D., Ilić-Tomić, T., Veljić, M., Tešević, V.,& Asakawa, Y. (2019). Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia cruciata. Journal of Natural Products, American Chemical Society (ACS), 82(4), 694-701. [https://doi.org/10.1021/acs.jnatprod.8b00390]Published version of the article: [https://cer.ihtm.bg.ac.rs/handle/123456789/2838

Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia cruciata

Seven new bisbibenzyls (1−7) were isolated from the methanol extract of the liverwort Lunularia cruciata along with one previously known bibenzyl and five known bisbibenzyls. The structures of compounds 1−7 were elucidated on the basis of the spectroscopic data. These newly isolated bisbibenzyls may be divided into two groups, the acyclic bisbibenzyls, perrottetins (1− 3), and the cyclic analogues, riccardins (4−7). Besides standard perrottetin and riccardin structures (1 and 4, respectively), they contain phenanthrene (3 and 5), dihydrophenanthrene (2), and quinone moieties (6 and 7), rarely found in natural products. The new compounds 3 and 5, as well as the known riccardin G, exhibited cytotoxic activity against the A549 lung cancer cell line with IC50 values of 5.0, 5.0, and 2.5 μM, respectively.Supporting information: [https://cer.ihtm.bg.ac.rs/handle/123456789/4449

Supplementary data for article: Novakovic, M.; Bukvicki, D.; Andjelkovic, B.; Ilic-Tomic, T.; Veljic, M.; Tesevic, V.; Asakawa, Y. Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia Cruciata. Journal of Natural Products 2019, 82 (4), 694–701. https://doi.org/10.1021/acs.jnatprod.8b00390

Supporting information for: [https://doi.org/10.1021/acs.jnatprod.8b00390]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/3096

Chemical Ecology of Cave-Dwelling Millipedes: Defensive Secretions of the Typhloiulini (Diplopoda, Julida, Julidae)

Cave animals live under highly constant ecological conditions and in permanent darkness, and many evolutionary adaptations of cave-dwellers have been triggered by their specific environment. A similar "cave effect" leading to pronounced chemical interactions under such conditions may be assumed, but the chemoecology of troglobionts is mostly unknown. We investigated the defensive chemistry of a largely cave-dwelling julid group, the controversial tribe "Typhloiulini", and we included some cave-dwelling and some endogean representatives. While chemical defense in juliform diplopods is known to be highly uniform, and mainly based on methyl- and methoxy-substituted benzoquinones, the defensive secretions of typhloiulines contained ethyl-benzoquinones and related compounds. Interestingly, ethyl-benzoquinones were found in some, but not all cave-dwelling typhloiulines, and some non-cave dwellers also contained these compounds. On the other hand, ethyl-benzoquinones were not detected in troglobiont nor in endogean typhloiuline outgroups. In order to explain the taxonomic pattern of ethyl-benzoquinone occurrence, and to unravel whether a cave-effect triggered ethyl-benzoquinone evolution, we classed the "Typhloiulini" investigated here within a phylogenetic framework of julid taxa, and traced the evolutionary history of ethyl-benzoquinones in typhloiulines in relation to cave-dwelling. The results indicated a cave-independent evolution of ethyl-substituted benzoquinones, indicating the absence of a "cave effect" on the secretions of troglobiont Typhloiulini. Ethyl-benzoquinones probably evolved early in an epi- or endogean ancestor of a clade including several, but not all Typhloiulus (basically comprising a taxonomic entity known as "Typhloiulus sensu stricto") and Serboiulus. Ethyl-benzoquinones are proposed as novel and valuable chemical characters for julid systematics.Supplementary material: [http://cherry.chem.bg.ac.rs/handle/123456789/3085

Supplementary data for article: Makarov, S. E.; Bodner, M.; Reineke, D.; Vujisić, L. V.; Todosijević, M. M.; Antić, D. Ž.; Vagalinski, B.; Lučić, L. R.; Mitić, B. M.; Mitov, P.; et al. Chemical Ecology of Cave-Dwelling Millipedes: Defensive Secretions of the Typhloiulini (Diplopoda, Julida, Julidae). Journal of Chemical Ecology 2017, 43 (4), 317–326. https://doi.org/10.1007/s10886-017-0832-1

Supplementary material for: [https://doi.org/10.1007/s10886-017-0832-1]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/2450

GUIDELINES FOR DIAGNOSIS, TREATMENT AND MONITORING PATIENTS WITH SMALL CELL LUNG CANCER

Rak pluća najučestalija je zloćudna bolest u muškaraca, a pri vrhu je učestalosti i u žena. Među oboljelima 15% čine bolesnici s rakom pluća malih stanica. S obzirom na agresivnu prirodu ove bolesti i lošu prognozu, vrlo je važno definirati i implementirati standardizirani pristup dijagnostičkoj obradi, liječenju, kao i praćenju ovih bolesnika. Metode liječenja uključuju kemoterapiju, radioterapiju i, rijetko, kirurgiju ovisno o stadiju bolesti i općem stanju bolesnika.Lung cancer is the most common male cancer, and one of the most common female cancers. Small cell lung cancers account for 15% of lung cancers. Due to the aggressiveness of the disease and bad prognosis, it is important to define and implement standardized approach for diagnostics, treatment and monitoring of these patients. Treatment modalities include chemotherapy, radiotherapy, and, rarely, surgery according to the stage of the disease and patient condition