60 research outputs found
Quantum Kinetic Theory of BEC Lattice Gas:Boltzmann Equations from 2PI-CTP Effective Action
We continue our earlier work [Ana Maria Rey, B. L. Hu, Esteban Calzetta,
Albert Roura and Charles W. Clark, Phys. Rev. A 69, 033610 (2004)] on the
nonequilibrium dynamics of a Bose Einstein condensate (BEC) selectively loaded
into every third site of a one-dimensional optical lattice. From the
two-particle irreducible (2PI) closed-time-path (CTP) effective action for the
Bose- Hubbard Hamiltonian, we show how to obtain the Kadanoff-Baym equations of
quantum kinetic theory. Using the quasiparticle approximation, we show that the
local equilibrium solutions of these equations reproduce the second- order
corrections to the self-energy originally derived by Beliaev. This work paves
the way for the use of effective action methods in the derivation of quantum
kinetic theory of many atom systems.Comment: 21 pages, 0 figures, minor editorial changes were mad
Finite-temperature simulations of the scissors mode in Bose-Einstein condensed gases
The dynamics of a trapped Bose-condensed gas at finite temperatures is
described by a generalized Gross-Pitaevskii equation for the condensate order
parameter and a semi-classical kinetic equation for the thermal cloud, solved
using -body simulations. The two components are coupled by mean fields as
well as collisional processes that transfer atoms between the two. We use this
scheme to investigate scissors modes in anisotropic traps as a function of
temperature. Frequency shifts and damping rates of the condensate mode are
extracted, and are found to be in good agreement with recent experiments.Comment: 4 pages, 3 figure
Finite temperature hydrodynamic modes of trapped quantum gases
The hydrodynamic equations of an ideal fluid formed by a dilute quantum gas
in a parabolic trapping potential are studied analytically and numerically. Due
to the appearance of internal modes in the fluid stratified by the trapping
potential, the spectrum of low-lying modes is found to be dense in the
high-temperature limit, with an infinitely degenerate set of zero-frequency
modes. The spectrum for Bose-fluids and Fermi-fluids is obtained and discussed.Comment: 26 pages, Late
Beyond Gross-Pitaevskii Mean Field Theory
A large number of effects related to the phenomenon of Bose-Einstein
Condensation (BEC) can be understood in terms of lowest order mean field
theory, whereby the entire system is assumed to be condensed, with thermal and
quantum fluctuations completely ignored. Such a treatment leads to the
Gross-Pitaevskii Equation (GPE) used extensively throughout this book. Although
this theory works remarkably well for a broad range of experimental parameters,
a more complete treatment is required for understanding various experiments,
including experiments with solitons and vortices. Such treatments should
include the dynamical coupling of the condensate to the thermal cloud, the
effect of dimensionality, the role of quantum fluctuations, and should also
describe the critical regime, including the process of condensate formation.
The aim of this Chapter is to give a brief but insightful overview of various
recent theories, which extend beyond the GPE. To keep the discussion brief,
only the main notions and conclusions will be presented. This Chapter
generalizes the presentation of Chapter 1, by explicitly maintaining
fluctuations around the condensate order parameter. While the theoretical
arguments outlined here are generic, the emphasis is on approaches suitable for
describing single weakly-interacting atomic Bose gases in harmonic traps.
Interesting effects arising when condensates are trapped in double-well
potentials and optical lattices, as well as the cases of spinor condensates,
and atomic-molecular coupling, along with the modified or alternative theories
needed to describe them, will not be covered here.Comment: Review Article (19 Pages) - To appear in 'Emergent Nonlinear
Phenomena in Bose-Einstein Condensates: Theory and Experiment', Edited by
P.G. Kevrekidis, D.J. Frantzeskakis and R. Carretero-Gonzalez (Springer
Verlag
Finite Temperature Models of Bose-Einstein Condensation
The theoretical description of trapped weakly-interacting Bose-Einstein
condensates is characterized by a large number of seemingly very different
approaches which have been developed over the course of time by researchers
with very distinct backgrounds. Newcomers to this field, experimentalists and
young researchers all face a considerable challenge in navigating through the
`maze' of abundant theoretical models, and simple correspondences between
existing approaches are not always very transparent. This Tutorial provides a
generic introduction to such theories, in an attempt to single out common
features and deficiencies of certain `classes of approaches' identified by
their physical content, rather than their particular mathematical
implementation.
This Tutorial is structured in a manner accessible to a non-specialist with a
good working knowledge of quantum mechanics. Although some familiarity with
concepts of quantum field theory would be an advantage, key notions such as the
occupation number representation of second quantization are nonetheless briefly
reviewed. Following a general introduction, the complexity of models is
gradually built up, starting from the basic zero-temperature formalism of the
Gross-Pitaevskii equation. This structure enables readers to probe different
levels of theoretical developments (mean-field, number-conserving and
stochastic) according to their particular needs. In addition to its `training
element', we hope that this Tutorial will prove useful to active researchers in
this field, both in terms of the correspondences made between different
theoretical models, and as a source of reference for existing and developing
finite-temperature theoretical models.Comment: Detailed Review Article on finite temperature theoretical techniques
for studying weakly-interacting atomic Bose-Einstein condensates written at
an elementary level suitable for non-experts in this area (e.g. starting PhD
students). Now includes table of content
Quantum dynamics and thermalization for out-of-equilibrium phi^4-theory
The quantum time evolution of \phi^4-field theory for a spatially homogeneous
system in 2+1 space-time dimensions is investigated numerically for
out-of-equilibrium initial conditions on the basis of the Kadanoff-Baym
equations including the tadpole and sunset self-energies. Whereas the tadpole
self-energy yields a dynamical mass, the sunset self-energy is responsible for
dissipation and an equilibration of the system. In particular we address the
dynamics of the spectral (`off-shell') distributions of the excited quantum
modes and the different phases in the approach to equilibrium described by
Kubo-Martin-Schwinger relations for thermal equilibrium states. The
investigation explicitly demonstrates that the only translation invariant
solutions representing the stationary fixed points of the coupled equation of
motions are those of full thermal equilibrium. They agree with those extracted
from the time integration of the Kadanoff-Baym equations in the long time
limit. Furthermore, a detailed comparison of the full quantum dynamics to more
approximate and simple schemes like that of a standard kinetic (on-shell)
Boltzmann equation is performed. Our analysis shows that the consistent
inclusion of the dynamical spectral function has a significant impact on
relaxation phenomena. The different time scales, that are involved in the
dynamical quantum evolution towards a complete thermalized state, are discussed
in detail. We find that far off-shell 1 3 processes are responsible for
chemical equilibration, which is missed in the Boltzmann limit. Finally, we
address briefly the case of (bare) massless fields. For sufficiently large
couplings we observe the onset of Bose condensation, where our scheme
within symmetric \phi^4-theory breaks down.Comment: 77 pages, 26 figure
The impact of malignant nipple discharge cytology (NDc) in surgical management of breast cancer patients
BACKGROUND: The role of nipple discharge cytology (NDc) in the surgical management of breast cancer patients is unclear. We aimed: (i) to evaluate the effect of malignant NDc on the surgical approach to the nipple-areola complex, and (ii) to verify the association between malignant NDc and nipple malignancy. METHODS: We retrospectively analyzed a case series of 139 patients with NDc who underwent breast surgery. The clinical and histological findings, types of surgery with emphasis on nipple-areola complex amputation, immunohistochemical phenotypes of the carcinomas and measurements of the tumor-nipple distance were recorded. Additionally, in patients who showed HER2-positive lesions on definitive surgery, we evaluated the HER2 immunocytochemistry of the NDc smears. RESULTS: Thirty-two malignant and 107 benign/borderline NDc diagnoses were identified. All 32 malignant-NDc cases were histologically confirmed as malignant. Thirty borderline/benign-NDc cases were histologically diagnosed as malignant (sensitivity 58%). The majority of the patients with malignant NDc were treated with nipple-areola complex amputations in both the mastectomy and conservative surgery groups (P<0.001, chi251.77). Nipple involvement was strongly associated with HER2-positive ductal carcinoma in-situ (P<0.001, chi211.98). HER2 immunocytochemistry on the NDc revealed a 100% correlation with the immunocytochemistry performed on the surgical tissues. CONCLUSIONS: Malignant NDc influenced surgical management. The association of malignant NDc with nipple involvement is highly related to ductal carcinoma in-situ with HER2 overexpression. In case of HER2 positive NDc, nipple-areola complex involvement is more likely than in HER2 negative cases
Molecular Networks in FGF Signaling: Flotillin-1 and Cbl-Associated Protein Compete for the Binding to Fibroblast Growth Factor Receptor Substrate 2
Fibroblast growth factor receptor substrate 2 (FRS2α) is a signaling adaptor protein that regulates downstream signaling of many receptor tyrosine kinases. During signal transduction, FRS2 can be both tyrosine and threonine phosphorylated and forms signaling complexes with other adaptor proteins and tyrosine phosphatases. We have here identified flotillin-1 and the cbl-associated protein/ponsin (CAP) as novel interaction partners of FRS2. Flotillin-1 binds to the phosphotyrosine binding domain (PTB) of FRS2 and competes for the binding with the fibroblast growth factor receptor. Flotillin-1 knockdown results in increased Tyr phosphorylation of FRS2, in line with the inhibition of ERK activity in the absence of flotillin-1. CAP directly interacts with FRS2 by means of its sorbin homology (SoHo) domain, which has previously been shown to interact with flotillin-1. In addition, the third SH3 domain in CAP binds to FRS2. Due to the overlapping binding domains, CAP and flotillin-1 appear to compete for the binding to FRS2. Thus, our results reveal a novel signaling network containing FRS2, CAP and flotillin-1, whose successive interactions are most likely required to regulate receptor tyrosine kinase signaling, especially the mitogen activated protein kinase pathway
IgG-like bispecific antibodies with potent and synergistic neutralization against circulating SARS-CoV-2 variants of concern
Monoclonal antibodies are a promising approach to treat COVID-19, however the emergence of SARS-CoV-2 variants has challenged the efficacy and future of these therapies. Antibody cocktails are being employed to mitigate these challenges, but neutralization escape remains a major challenge and alternative strategies are needed. Here we present two anti-SARS-CoV-2 spike binding antibodies, one Class 1 and one Class 4, selected from our non-immune human single-chain variable fragment (scFv) phage library, that are engineered into four, fully-human IgG-like bispecific antibodies (BsAb). Prophylaxis of hACE2 mice and post-infection treatment of golden hamsters demonstrates the efficacy of the monospecific antibodies against the original Wuhan strain, while promising in vitro results with the BsAbs demonstrate enhanced binding and distinct synergistic effects on neutralizing activity against circulating variants of concern. In particular, one BsAb engineered in a tandem scFv-Fc configuration shows synergistic neutralization activity against several variants of concern including B.1.617.2. This work provides evidence that synergistic neutralization can be achieved using a BsAb scaffold, and serves as a foundation for the future development of broadly reactive BsAbs against emerging variants of concern
Kinetic effects of poly(6-thioinosinic acid), poly(s6i), on l1210 cells in vitro. Abstr.
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