Medical treatment of early stage and rare histological variants of epithelial ovarian cancer

Epithelial ovarian cancer is often considered a single pathological entity, but increasing evidence suggests that it is rather a group of different neoplasms, each with unique pathological characteristics, molecular features, and clinical behaviours. This heterogeneity accounts for the different sensitivity to antineoplastic drugs and makes the treatment of ovarian tumours a challenge. For early-stage disease, as well as for heavily pre-treated patients with recurrent ovarian cancer, the benefit of chemotherapy remains uncertain. Clear-cell, mucinous, low-grade serous, and endometrioid carcinomas show different molecular characteristics, which require different therapeutic approaches. In the era of personalised cancer medicine, understanding the pathogenesis and the genetic background of each subtype of epithelial ovarian tumour may lead to a tailored therapy, maximising the benefits of specific treatments and possibly reducing the side effects. Furthermore, personal factors, such as the patient’s performance status, should be taken into account in the management of ovarian cancer, with the aim of safeguarding the patients’ quality of life

Cognitive reserve in dementia: Implications for cognitive training

open9noCognitive reserve (CR) is a potential mechanism to cope with brain damage. The aim of this study was to evaluate the effect of CR on a cognitive training (CT) in a group of patients with dementia. Eighty six participants with mild to moderate dementia were identified by their level of CR quantified by the CR Index questionnaire (CRIq) and underwent a cycle of CT. A global measure of cognition mini mental state examination (MMSE) was obtained before (T0) and after (T1) the training. Multiple linear regression analyses highlighted CR as a significant factor able to predict changes in cognitive performance after the CT. In particular, patients with lower CR benefited from a CT program more than those with high CR. These data show that CR can modulate the outcome of a CT program and that it should be considered as a predictive factor of neuropsychological rehabilitation training efficacy in people with dementia.openMondini, Sara; Madella, Ileana; Zangrossi, Andrea; Bigolin, Angela; Tomasi, Claudia; Michieletto, Marta; Villani, Daniele; Di Giovanni, Giuseppina; Mapelli, DanielaMondini, Sara; Madella, Ileana; Zangrossi, Andrea; Bigolin, Angela; Tomasi, Claudia; Michieletto, Marta; Villani, Daniele; Di Giovanni, Giuseppina; Mapelli, Daniel

One- and two-proton transfer reactions with vibrational Nuclei

We extend a semiclassical model of transfer reactions to the case in which one of the collision partners is a vibrational nucleus. The model is applied to one- and two-proton stripping reactions in the 37Cl + 98Mo system, for which a rapid transition from normal to anomalous slope in the two proton transfer reaction at energies around the Coulomb barrier is experimentally observed. This behavior is satisfactorily reproduced by the present extension of the model.Comment: LaTeX, 10 pages, 1 figure (PostScript

The Italian Way for Research Biobanks After GDPR: Hybrid Normative Solutions to Balance the Protection of Individuals and Freedom of Research

AbstractThe Italian context of biobanking is made up of a vast number of collections, in some cases well-organised and connected in virtuous networks and in others not identifiable as structured biobanks. From a comparative perspective, Italy can be regarded as a hybrid model, positioned between countries with full and detailed legislation concerning biobanks and those that rely only on guidelines published by national ethics committees or professional societies that have no binding legal value. In countries like Italy where the need for specific regulation is more urgent, the entry into force of the GDPR could have offered a chance to fill the gap in the legislation with regard to biobanking for medical scientific research purposes. This overview highlights the improvements made and the obstacles that persist

Legal issues in governing genetic biobanks : the Italian framework as a case study for the implications for citizen’s health through public-private initiatives

Deborah Mascalzoni is funded by RD-Connect under grant agreement number 30544.Peer reviewedPublisher PD

The Isotropic Fractionator as a Tool for Quantitative Analysis in Central Nervous System Diseases

One major aim in quantitative and translational neuroscience is to achieve a precise and fast neuronal counting method to work on high throughput scale to obtain reliable results.Here we tested the Isotropic Fractionator (IF) method for evaluating neuronal and non-neuronal cell loss in different models of central nervous system (CNS) pathologies.Sprague-Dawley rats underwent: (i) ischemic brain damage; (ii) intraperitoneal injection with kainic acid (KA) to induce epileptic seizures; and (iii) monolateral striatal injection with quinolinic acid (QA) mimicking human Hungtington’s disease.All specimens were processed for IF method and cell loss assessed.Hippocampus from KA-treated rats and striatum from QA-treated rats were carefully dissected using a dissection microscope and a rat brain matrix. Ischemic rat brains slices were first processed for TTC staining and then for IF.In the ischemic group the cell loss corresponded to the neuronal loss suggesting that hypoxia primarily affects neurons. Combining IF with TTC staining we could correlate the volume of lesion to the neuronal loss; by IF, we could assess that neuronal loss also occurs contralaterally to the ischemic side.In the epileptic group we observed a reduction of neuronal cells in treated rats, but also evaluated the changes in the number of non-neuronal cells in response to the hippocampal damage

Initial Characterization of CASQ1/CASQ2 Knockout (double CASQ-Null) Mice

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Leitura:uma proposta

Este trabalho apresenta algumas tcnicas para incentivar o aluno a desenvolver o hbito de leitura e realizar umaleitura mais efetiva. Levando em considerao que o aluno normalmente tem dificuldades na atividade de leitura, acreditamosque cada vez mais se faz necessria a elaborao de estratgias de leitura. Com este objetivo, utilizamos estratgias formuladaspor Sol (1998) cujas atividades de leitura podem conter inmeros objetivos em situaes e momentos diversos. Na opinio daautora todos esses objetivos merecem ser considerados. Assim, apresentamos um estudo dos momentos de pr-leitura, durantea leitura e ps-leitura elaborados pela autora j citada. O texto escolhido Aquele Estranho Animal de Mario Quintana.O que levamos em considerao para a escolha deste texto, foram s variedades de aspectos que poderiam ser abordadosem todos os momentos da leitura, motivando e despertando os interesses dos alunos no que diz respeito decodificao, compreenso, interpretao e reteno do material de leitura

FÓRUM CIENTÍFICO DE ESTUDOS EM PACIENTES ESPECIAIS

A identificação e estudo de experiências e estratégias em serviços de saúde capacitam ao acadêmico o exercício e possibilidade de elaboração de planejamento em saúde em diferentes tipos populacionais. A atuação do acadêmico de odontologia junto ao paciente especial leva ao crescimento constante do interesse e conhecimentos pelos processos educativos em saúde bucal e da humanização do atendimento odontológico. O fórum científico de estudos em pacientes especiais possibilita aos acadêmicos e professores do curso de odontologia a aportunidade de aprimoramento técnico-cinetífico através da realização de pesquisa e debate sobre programas desenvolvidos pelo Ministério da saúde e a inserção do profissinal cirurgião-dentista nos mesmos. Para elaboração do artigo final e debate de apresentação são realizadas três oficinas de pesquisa na biblioteca central do Campus de Joaçaba. Após a confecção do artigo escrito e apresentação em formato power point, são realizadas 3 prévias da apresentação oral, com o intuito de debate, correções finais e treinamento de oratória. A apresentação final ocorre no formato de mesa redonda, com convidados de diferentes meios, alunos e professores do curso de odontologia. Cada semestre um novo tema é escolhido, dependendo da necessidade de se conhecer algum assunto ou programa específico do Ministério da Saúde. É um importante momento de troca de experiências e reflexões entre os acadêmicos e profissionais envolvidos, proporcionando uma aproximação com a comunidade e ao mesmo tempo contribuindo para a valorização profissional do cirurgião dentista.