Turbine Spirometers Metrological Support

This article deals with the description of the device and principle of the turbine spirometer action. Mathematic model of the rotation of the rotor of the measuring turbine is shown. According to the results of the turbine research the method of determine the coefficients of the conversion function is proposed. In this paper experimental studies of the proposed method are conducted. Research results have shown the adequacy of the description of the transformation function and methods for determining the coefficients

К ВОПРОСУ О КОНТРОЛЕ ФИЗИОЛОГИЧЕСКИХ ПОКАЗАТЕЛЕЙ ПРИ ПРОВЕДЕНИИ ПРОЦЕДУРЫ ГЕМОДИАЛИЗА

А comparative analysis of existing methods of the control patient’s health during procedure of hemodialysis provides in this article. Interrelation of indexes describes. Also, the necessity of search indexes, which are dependent on the hydration of the extracellular fluid and which can be monitored in real time throughout the entire procedure, is justified. Ref. 4, fig. 2.В данной статье проведен сравнительный анализ существующих методов контроля состояния пациента в ходе процедуры гемодиализа. Описана взаимосвязь физиологических показателей. Также обоснована необходимость поиска показателей, которые находятся в непосредственной зависимости от гидратации внеклеточного пространства и которые возможно мониторировать в реальном режиме времени на протяжении всей процедуры.Библ.4, рис 2.У даній статті проведений порівняльний аналіз існуючих методів контролю стану пацієнта в ході процедури гемодіалізу. Описаний взаємозв'язок фізіологічних показників. Також обгрунтована необхідність пошуку показників, які знаходяться в безпосередній залежності від гідратації позаклітинного простору і які можливо моніторіровать в реальному режимі часу впродовж всієї процедури. Бібл.4, рис 2

NCBI GEO: archive for high-throughput functional genomic data

The Gene Expression Omnibus (GEO) at the National Center for Biotechnology Information (NCBI) is the largest public repository for high-throughput gene expression data. Additionally, GEO hosts other categories of high-throughput functional genomic data, including those that examine genome copy number variations, chromatin structure, methylation status and transcription factor binding. These data are generated by the research community using high-throughput technologies like microarrays and, more recently, next-generation sequencing. The database has a flexible infrastructure that can capture fully annotated raw and processed data, enabling compliance with major community-derived scientific reporting standards such as ‘Minimum Information About a Microarray Experiment’ (MIAME). In addition to serving as a centralized data storage hub, GEO offers many tools and features that allow users to effectively explore, analyze and download expression data from both gene-centric and experiment-centric perspectives. This article summarizes the GEO repository structure, content and operating procedures, as well as recently introduced data mining features. GEO is freely accessible at http://www.ncbi.nlm.nih.gov/geo/

NCBI GEO: archive for functional genomics data sets—10 years on

A decade ago, the Gene Expression Omnibus (GEO) database was established at the National Center for Biotechnology Information (NCBI). The original objective of GEO was to serve as a public repository for high-throughput gene expression data generated mostly by microarray technology. However, the research community quickly applied microarrays to non-gene-expression studies, including examination of genome copy number variation and genome-wide profiling of DNA-binding proteins. Because the GEO database was designed with a flexible structure, it was possible to quickly adapt the repository to store these data types. More recently, as the microarray community switches to next-generation sequencing technologies, GEO has again adapted to host these data sets. Today, GEO stores over 20 000 microarray- and sequence-based functional genomics studies, and continues to handle the majority of direct high-throughput data submissions from the research community. Multiple mechanisms are provided to help users effectively search, browse, download and visualize the data at the level of individual genes or entire studies. This paper describes recent database enhancements, including new search and data representation tools, as well as a brief review of how the community uses GEO data. GEO is freely accessible at http://www.ncbi.nlm.nih.gov/geo/

Discourse organization in the comprehension of temporal order in narrative texts

We investigated the role of global discourse organization on the comprehension of temporal order in narrative. We proposed three principles of discourse organization: (a) the immediate integration principle--- new event should be integrated immediately with old information, (b) the consistency principle---a new event should be attached to a consistent locus, and (c) the isomorphism principle---discourse structure should match event structure. Five passages varying in discourse structure were presented auditorily, and the comprehension of the underlying event order was tested. Subjects' comprehension was best in the canonical passage. The backward, flashback, and embedded passages were significantly more difficult than the canonical passages. The flashforward passage was the most difficult. The results were interpreted as showing that the immediate integration principle is a strong component of comprehension of temporal order and that the isomorphism principle contributes to text comprehension, but to a lesser degree